Results 111 to 120 of about 4,657 (257)

Genetic Inactivation of the Serotonin Transporter Dysregulates Expression of Neurotransmission Genes and Genome‐Wide DNA Methylation Levels in the Medial Prefrontal Cortex of Male Rats During Postnatal Development

Developmental Neurobiology, Volume 85, Issue 3, July 2025.
ABSTRACT Reduced expression of the serotonin transporter (5‐hydroxytryptamine transporter, 5‐HTT) in early life has been associated with a delay in postnatal brain development and endophenotypes of a variety of neuropsychiatric and neurodevelopmental disorders in adolescence and adulthood.
Yvet Kroeze, Martin Oti, Roel H. M. Cooijmans, Ellen van Beusekom, Leonie I. Kroeze, Anthonieke Middelman, Hans van Bokhoven, Sharon M. Kolk, Judith R. Homberg, Huiqing Zhou   +9 more
wiley   +1 more source

Genome-Wide Association of Genetic Variants With Refraction, Axial Length, and Corneal Curvature: A Longitudinal Study of Chinese Schoolchildren

Frontiers in Genetics, 2020
BackgroundMyopia is a common eye disorder that is approaching epidemic proportions worldwide. A genome-wide association study identified AREG (rs12511037), GABRR1 (rs13215566), and PDE10A (rs12206610) as being associated with refractive error in Asian ...
Yaoyao Lin, Yu Ding, Dandan Jiang, Chunchun Li, Xiaoqiong Huang, Linjie Liu, Haishao Xiao, Balamurali Vasudevan, Yanyan Chen   +8 more
doaj   +1 more source

A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition. [PDF]

PLoS ONE, 2013
A cell-based high-throughput screen (HTS) was developed to detect phosphodiesterase 8 (PDE8) and PDE4/8 combination inhibitors. By replacing the Schizosaccharomyces pombe PDE gene with the murine PDE8A1 gene in strains lacking adenylyl cyclase, we ...
Didem Demirbas, Arlene R Wyman, Masami Shimizu-Albergine, Ozgur Cakici, Joseph A Beavo, Charles S Hoffman   +5 more
doaj   +1 more source

Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. [PDF]

, 2016
To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat lengths.
A Dobin, A Hodges, A Kuhn, A Pal, A Reiner, A Valencia, Andreas Tebbe, B Zhang, B Zhang, BM Bolstad, C Zuccato, CA Ross, Christoph Schaab, Daniel J Lavery, David Howland, DI Shirasaki, Doxa Chatzopoulou, DV Zaykin, EH Aylward, Eliana Marisa Ramos, ES Deneris, ES Lein, Fuying Gao, G Fishell, GA Smith, Giovanni Coppola, HT Orr, I Al-Ramahi, IS Seong, Ismael Al-Ramahi, J Cox, J Cox, J Labbadia, JA Miller, JC Jacobsen, JE Phillips, Jeffrey P Cantle, Jeffrey S Aaronson, JF Gusella, JF Gusella, Jim Rosinski, JM Dowen, JM Van Raamsdonk, JP Vonsattel, Juan Botas, K Becanovic, K Monahan, K Sharma, Karla El-Zein, LB Menalled, LB Menalled, LB Menalled, LS Kaltenbach, M Biagioli, M Heiman, M MACDONALD, M Mann, M Mielcarek, MA Pouladi, MC Oldham, MI Love, MK Lobo, MT Lin, N Wang, Nan Wang, P Giles, P Grange, P Langfelder, P Langfelder, P Langfelder, P Langfelder, P Langfelder, Peter Langfelder, PF Durrenberger, RC Gentleman, S Anders, S Horvath, S Toyoda, Sandeep Deverasetty, Seung Kwak, Steve Horvath, T Geiger, T Lu, WE Johnson, WV Chen, X Gu, X Gu, X William Yang, XH Lu, Xiao-Hong Lu, Y Benjamini, Y Guo, Y Shen, Y Wang, Yining Zhao   +94 more
core   +1 more source

Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast transformation in Peyronie's disease

BJU International, Volume 135, Issue 5, Page 810-817, May 2025.
Objectives To investigate which phosphodiesterase (PDE) isoforms are expressed in fibroblasts isolated from the tunica albuginea (TA) of patients with Peyronie's disease (PD), and to measure the potency of PDE inhibitors in preventing transformation of these fibroblasts to profibrotic myofibroblasts.
Sophie L. Harding, Marcus M. Ilg, Stephen A. Bustin, David J. Ralph, Selim Cellek   +4 more
wiley   +1 more source

Advanced Research on Dopamine Signaling to Develop Drugs for the Treatment of Mental Disorders: Biochemical and Behavioral Profiles of Phosphodiesterase Inhibition in Dopaminergic Neurotransmission

Journal of Pharmacological Sciences, 2010
Dopamine plays a central role in the regulation of psychomotor functions. The effect of dopamine is largely mediated through the cAMP/PKA signaling cascade and therefore controlled by phosphodiesterases (PDEs).
Akinori Nishi, Gretchen L. Snyder
doaj   +1 more source

Genome-wide association study in bipolar patients stratified by co-morbidity. [PDF]

PLoS ONE, 2011
Bipolar disorder is a severe psychiatric disorder with high heritability. Co-morbid conditions are common and might define latent subgroups of patients that are more homogeneous with respect to genetic risk factors.In the Caucasian GAIN bipolar disorder ...
Berit Kerner, Christophe G Lambert, Bengt O Muthén   +2 more
doaj   +1 more source

High‐Throughput Immunoassays for Cavin‐4 IgG: A Diagnostic Tool for Immune‐Mediated Rippling Muscle Disease

Annals of Clinical and Translational Neurology, Volume 12, Issue 4, Page 876-880, April 2025.
ABSTRACT Cavin‐4 was identified as a potential autoantigen for immune‐mediated rippling muscle disease (iRMD). To validate this, we developed and tested various immunoassays, including a cell‐based assay (CBA), cavin‐4 recombinant protein ELISA, and multi‐peptide ELISA.
Reghann G. LaFrance‐Corey, Haidara Kherbek, Nimalan Harinesan, Margherita Milone, Naveen K. Paramasivan, Pallab Sarker, Andrew M. Knight, Carley Karsten, Surendra Dasari, Teerin Liewluck, William J. Litchy, Sean J. Pittock, John R. Mills, Divyanshu Dubey   +13 more
wiley   +1 more source

Papaverine Targets STAT Signaling: A Dual‐Action Therapy Option Against SARS‐CoV‐2

Journal of Medical Virology, Volume 97, Issue 4, April 2025.
ABSTRACT Papaverine (PV) has been previously identified as a promising candidate in SARS‐CoV‐2 repurposing screens. In this study, we further investigated both its antiviral and immunomodulatory properties. PV displayed antiviral efficacy against SARS‐CoV‐2 and influenza A viruses H1N1 and H5N1 in single infection as well as in co‐infection.
Philipp Reus, Emma Torbica, Tamara Rothenburger, Marco Bechtel, Joshua Kandler, Sandra Ciesek, Philip Gribbon, Aimo Kannt, Jindrich Cinatl, Denisa Bojkova   +9 more
wiley   +1 more source

Microglial cGAS Deletion Preserves Intercellular Communication and Alleviates Amyloid‐β‐Induced Pathogenesis of Alzheimer's Disease

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Innate immune activation plays a vital role in the development of Alzheimer's disease, yet the mechanisms remain unclear. This study identifies microglial cGAMP synthase (cGAS) as a central driver of amyloid‐β pathology and unveils a novel microglia‐myelin crosstalk mediated by pleiotrophin. These findings provide groundbreaking insights into microglia'
Sijia He, Xin Li, Namrata Mittra, Anindita Bhattacharjee, Hu Wang, Shujie Song, Shangang Zhao, Feng Liu, Xianlin Han   +8 more
wiley   +1 more source