Results 121 to 130 of about 4,135 (194)

Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety

, 2019
Yuuki Koizumi, Yoshihito Tanaka, Takehiko Matsumura, Yoichi Kadoh, Haruko Miyoshi, Mitsuya Hongu, Kei Takedomi, Jun Kotera, Takashi Sasaki, Hiroyuki Taniguchi, Yumi Watanabe, Misae Takakuwa, Koki Kojima, Nobuyuki Baba, Itsuko Nakamura, Eiji Kawanishi   +15 more
openalex   +1 more source

Identification of PDE10A related proteins via proteomic analysis

, 2022
Mustafa Çağlar Beker, Hayriye Ecem Yelkenci, Berrak Çağlayan, Ertuğrul Kılıç   +3 more
openalex   +1 more source

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source

Rapid Identification of a Novel Small Molecule Phosphodiesterase 10A (PDE10A) Tracer

, 2012
Essa Hu, Ji Ma, Christopher Biorn, Dianna Lester-Zeiner, Robert Cho, Shannon Rumfelt, Roxanne K. Kunz, Thomas Nixey, Klaus Michelsen, Silke Miller, Jianxia Shi, Jamie Wong, Geraldine Hill Della Puppa, Jessica Able, Santosh Talreja, Dah‐Ren Hwang, Stephen A. Hitchcock, Amy C. Porter, David Immke, Jennifer R. Allen, James Treanor, Hang Chen   +21 more
openalex   +1 more source

Discovery of Phosphodiesterase 10A (PDE10A) PET Tracer AMG 580 to Support Clinical Studies

, 2016
Essa Hu, Ning Chen, Roxanne K. Kunz, Dah‐Ren Hwang, Klaus Michelsen, Carl D. Davis, Ji Ma, Jianxia Shi, Dianna Lester-Zeiner, Randall W. Hungate, James Treanor, Hang Chen, Jennifer R. Allen   +12 more
openalex   +1 more source

Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate

, 2014
Jinda Fan, Xiang Zhang, Junfeng Li, Hongjun Jin, Prashanth K. Padakanti, Lynne A. Jones, Hubert Flores, Yi Su, Joel S. Perlmutter, Zhude Tu   +9 more
openalex   +1 more source

Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors

, 2012
Essa Hu, Roxanne K. Kunz, Shannon Rumfelt, Ning Chen, Roland W. Bürli, Chun Li, Kristin L. Andrews, Jiandong Zhang, Samer Chmait, Jeffrey H. Kogan, Michelle Lindström, Stephen A. Hitchcock, James Treanor   +12 more
openalex   +1 more source

Modulation of mGlu2 Receptors, but Not PDE10A Inhibition Normalizes Pharmacologically-Induced Deviance in Auditory Evoked Potentials and Oscillations in Conscious Rats

, 2016
A. Ahnaou, R. Biermans, Wilhelmus Drinkenburg   +2 more
openalex   +2 more sources

Triazolo Derivatives as Inhibitors of PDE10A

, 2014
Jean-François Brazeau, Gérard Rossé
openalex   +1 more source

Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1 H -pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).

, 2009
Patrick R. Verhoest, Douglas S. Chapin, Michael L. Corman, Kari R. Fonseca, John F. Harms, Xinjun Hou, Eric S. Marr, Frank S. Menniti, Frederick Nelson, Rebecca E. O’Connor, Jayvardhan Pandit, Caroline Proulx-LaFrance, Anne W. Schmidt, Christopher J. Schmidt, Judith A. Suiciak, Spiros Liras   +15 more
openalex   +1 more source