Results 121 to 130 of about 4,657 (257)
Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives
Molecules, 2020 In this study, a series of compounds derived from 4-methoxy-1H-isoindole-1,3(2H)-dione, potential ligands of phosphodiesterase 10A and serotonin receptors, were investigated as potential antipsychotics.Anna Czopek, Anna Partyka, Adam Bucki, Maciej Pawłowski, Marcin Kołaczkowski, Agata Siwek, Monika Głuch-Lutwin, Paulina Koczurkiewicz, Elżbieta Pękala, Anna Jaromin, Bożena Tyliszczak, Anna Wesołowska, Agnieszka Zagórska +12 moredoaj +1 more sourceMouse models of neurodegenerative disease: preclinical imaging and neurovascular component. [PDF]
, 2018 Neurodegenerative diseases represent great challenges for basic science and clinical medicine because of their prevalence, pathologies, lack of mechanism-based treatments, and impacts on individuals.A Bellucci, A Bonito-Oliva, A Boroujerdi, A Brockington, A Burgess, A Dorr, A Lockhart, A Manook, A Parievsky, A Rahman, A Rönnbäck, A Snellman, A Vercelli, AB Muñoz-Manchado, AD Kane, Adelaide Greco, AF Martins, AF Mellin, AG Barbeito, AH Jacobs, AI Brooks, AJ Lin, AK Srivastava, AL Brownell, AL Southwell, AM Hall, AP Patterson, AR Varma, AY Lai, B Joglar, B Oosthuyse, B Ott, B Platt, B Schwendele, B Stankoff, B Vastenhouw, BJ Turner, BS Buddeberg, C Bigot, C Casteels, C Cauwenberghe Van, C Cepeda, C Klein, C Procaccini, C Romberg, CA Denny, CA Hawkes, CE Moussa, CG Radu, CI Choi, CJ Macmillan, CY Lin, D Alvarez-Fischer, D Dam Van, D Diorio, D Hare, D Havas, D Liebetanz, D Litteljohn, D McLean, D Paula Faria de, D Rial, DA Shear, DM Iascone, DP McCarthy, DW Luchtman, DW Zang, DW Zang, E Milner, E Rockenstein, E Storkebaum, EK Agyare, EL Oleszak, EM Knight, EM Robbins, F Blandini, F Gilli, F Hébert, F Kara, F Luo, F Luo, F Mattner, FS Roman, G Andringa, G Kreiner, G Poisnel, G Rougon, GD Vickle Van, GE Meredith, GE Woloschak, GF Passos, GL Bowman, H Benveniste, H Brautigam, H Gu, H Li, H Oakley, H Schmalbruch, H Xiong, HB Fernandes, HG Niessen, HJ Newbery, HJ Waldvogel, HK Li-Chun, HV Vinters, HY Hsiao, I Dewachter, I Peruga, I Rattray, IG Kirkinezos, IR Macdonald, J Apelt, J Beauquis, J Boix, J Dorpe Van, J Drouin-Ouellet, J Grandjean, J Hua, J Klohs, J Klohs, J Lengfeld, J Luo, J Mahler, J Pépin, J Zhang, JA Helpern, JC Furtado, JC Glorioso, JD Lee, JE Hanson, JF Poduslo, JF Reilly, JJ Steventon, JK Ryu, JL Berard, JL Jankowsky, JL Lynch, JM Moser, JM Raamsdonk Van, JM Redwine, JP Lerch, JS Lunn, JS Toomey, K Miyazaki, K Miyazaki, K Poesen, KA Jellinger, KJ Bryan, KK Cheng, KK Kandimalla, KL Berggren, KM Jaruszewski, KR Rekha, KR Stover, KS Lindenberg, KS Lowry, KS Montgomery, L Auletta, L Chen, L Giménez-Llort, L Holcomb, L Mao, L Mucke, LA Thomason, LB Tovar-y-Romo, LH Wang, LI Bruijn, LM Gorton, Luigi Auletta, M Aggarwal, M Azzouz, M Baranyi, M Honer, M Knobloch, M Mancini, M Terzioglu, M Tóth, M Ziebell, M-J Lee, MA Busche, MA Hickey, Marcello Mancini, MC Evans, MD Meadowcroft, MD Santin, ML James, ML Starkey, MM Khalil, MM Paz Soldán, MY Heng, N Beckmann, N Nathoo, N Nathoo, NG Spencer, NM Lewandowski, O Philipson, OP Keifer Jr., P Bagga, P Bose, P Dibaj, P Kennel, P Zamboni, PM Switonski, PN Lacor, PO Fernagut, PO Fernagut, PO Fernagut, R Berg Van den, R Betarbet, R Chamberlain, R Chang, R Günther, R Muramatsu, R Zhang, RA Grant, RL Faull, RM Deacon, RM Nicholson, S Acharjee, S Fjær, S Franciosi, S Gargiulo, S George, S Kikuta, S Knippenberg, S Knippenberg, S Kumar-Singh, S Kumar-Singh, S Nessler, S Oddo, S Oddo, S Oliván, S Onida, S Ramaswamy, S Rojas, S Sarkar, S Serres, S Venneti, Sandra Albanese, SD Girard, SJ Sawiak, SJ Teipel, SJ Webster, SK Sharma, SM Fleming, SM Fleming, SR Suwijn, T Arora, T Spires-Jones, T Yamasaki, T Yasuhara, TN Luong, TN Taylor, TN Taylor, TO Abakumova, V Bogaerts, VL Eaton, W Atkinson, W Lin, W Lu, W Xu, WA Roscoe, WL Klein, WT Lee, X Wang, Y Cheng, Y Kishimoto, Y Li, Y Liu, Y Waerzeggers, Y Wei, Y Zhao, Y Zhou, YZ Wadghiri, YZ Wadghiri, Z Zhong +275 morecore +1 more sourcePreclinical evaluation of [18F]JNJ42259152 as a PET tracer for PDE10A
NeuroImage, 2013 Phosphodiesterase-10A (PDE10A) is implicated in several neuropsychiatric disorders involving basal ganglia neurotransmission, such as schizophrenia, obsessive-compulsive disorder and Huntington's disease. To confirm target engagement and exposure-occupancy relationships of clinical candidates for treatment, and to further explore the in vivo biology of Guy Bormans, M. De Angelis, Alfons Verbruggen, José Ignacio Andrés, Xavier Langlois, Maarten Ooms, Julie Cornelis, Ivan Sannen, Sofie Celen, Mark E. Schmidt, Michel Koole, Jesús Alcázar, K. Van Laere +12 moreopenaire +3 more sourcesCross‐pathway integration of cAMP signals through cGMP and calcium‐regulated phosphodiesterases in mouse striatal cholinergic interneurons
British Journal of Pharmacology, Volume 182, Issue 5, Page 1236-1253, March 2025.Abstract Background and Purpose
Acetylcholine plays a key role in striatal function. Firing properties of striatal cholinergic interneurons depend on intracellular cAMP through the regulation of Ih currents. Yet, the dynamics of cyclic nucleotide signalling in these neurons have remained elusive.Ségolène Bompierre, Yelyzaveta Byelyayeva, Elia Mota, Marion Lefevre, Anna Pumo, Jan Kehler, Liliana R. V. Castro, Pierre Vincent +7 morewiley +1 more sourceAutomation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production. [PDF]
, 2018 The development of new positron-emission tomography (PET) tracers is enabling researchers and clinicians to image an increasingly wide array of biological targets and processes.Collins, Jeffrey, Drake, Christopher, Schopf, Eric, Slavik, Roger, van Dam, R Michael, Waldmann, Christopher M +5 morecore Anti‐Prion Systems in Saccharomyces cerevisiae
Journal of Neurochemistry, Volume 169, Issue 3, March 2025.Yeast pathogenic prions have the same in‐register parallel folded β‐sheet architecture as infectious amyloids of human transmissible spongiform encephalopathy, Alzheimer's disease, Parkinson's disease, and type 2 diabetes. Six anti‐prion systems in yeast (identified by their gene names) together lower the load of prions detected ~5000‐fold by blocking ...Reed B. Wickner, Yuho Hayashi, Herman K. Edskes +2 morewiley +1 more sourceNurr1 protein is required for N-Methyl-d-aspartic Acid (NMDA) receptor-mediated neuronal survival [PDF]
, 2012 NMDA receptor (NMDAR) stimulation promotes neuronal survival during brain development. Cerebellar granule cells (CGCs) need NMDAR stimulation to survive and develop.Badiola Benito, Nahuai, Barneda Zahonero, Bruna, Fadó, Rut, Miñano Molina, Alfredo Jesús, Rodríguez Álvarez, José, Saura Antolín, Carlos A., Servitja i Duque, Joan-Marc +6 morecore +2 more sourcesExpression and Regulation of Cyclic Nucleotide Phosphodiesterases in Human and Rat Pancreatic Islets [PDF]
, 2010 As shown by transgenic mouse models and by using phosphodiesterase 3 (PDE3) inhibitors, PDE3B has an important role in the regulation of insulin secretion in pancreatic β-cells. However, very little is known about the regulation of the enzyme.A Dov, A Rascon, A Sahu, A Sjoholm, A Sjoholm, AZ Zhao, AZ Zhao, AZ Zhao, B Kreymann, C Ammala, D Vander Mierde, D Waddleton, D Willoughby, E Degerman, E Degerman, E Zmuda-Trzebiatowska, Emilia Heimann, Eva Degerman, F Ahmad, F Murad, H Eriksson, H Shibata, HA Walz, HA Walz, HE Hohmeier, Helena A. Jones, IB Leibiger, J Dupre, J Wijkander, JA Beavo, JC Parker, JC Parker, Kathrin Maedler, L Harndahl, L Härndahl, L Härndahl, L Härndahl, LD Cantin, Lena Stenson, M Ahmad, M El-Metwally, M Taira, ML Elks, MM Bradford, NJ Pyne, P Cheung, P Han, R Lindh, R Shafiee-Nick, S Seino, SG Straub, Svante Resjö, T Kitamura, T Miki, T Rahn, Vincent C. Manganiello, YH Choi +56 morecore +3 more sources
