Results 131 to 140 of about 4,657 (257)
Mechanisms for the Modulation of Dopamine D1 Receptor Signaling in Striatal Neurons [PDF]
, 2011 In the striatum, dopamine D1 receptors are preferentially expressed in striatonigral neurons, and increase the neuronal excitability, leading to the increase in GABAergic inhibitory output to substantia nigra pars reticulata.
Akinori eNishi +5 more
core +3 more sources
Quantitative metrics for drug-target ligandability. [PDF]
, 2018 Ligandability is a prerequisite for druggability and is a much easier concept to understand, model and predict because it does not depend on the complex pharmacodynamic and pharmacokinetic mechanisms in the human body.
Huggins, David J, Vukovic, Sinisa
core +1 more source
PLoS Genetics, 2013 Thyroid hormone is essential for normal metabolism and development, and overt abnormalities in thyroid function lead to common endocrine disorders affecting approximately 10% of individuals over their life span.
Eleonora Porcu +93 more
doaj +1 more source
Expression analysis of novel striatal-enriched genes in Huntington disease [PDF]
, 2017 Selective degeneration of striatal neurons is a pathologic hallmark of Huntington disease (HD). The exact mechanism(s) behind this specific neurodegeneration is still unknown.
Becanovic, Kristina +5 more
core
Striatal Vulnerability in Huntington’s Disease : Neuroprotection Versus Neurotoxicity [PDF]
, 2020 Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat encoding an abnormally long polyglutamine tract (PolyQ) in the huntingtin (Htt) protein.
Goto, Satoshi, Morigaki, Ryoma
core
New Dual PDE1B and PDE10A Inhibitors Identified via Ligand-Based Pharmacophore Modelling and Virtual Screening [PDF]
, 2023 Ching Wen Soon +2 more
openalex +1 more source
The human phosphodiesterase PDE10A gene [PDF]
, 2000 Kotomi Fujishige +3 more
openalex +1 more source