Results 11 to 20 of about 4,135 (194)

Evaluation of the acute oral toxicity and antipsychotic activity of a dual inhibitor of PDE1B and PDE10A in rat model of schizophrenia.

PLoS ONE, 2022
Phosphodiesterase 1B (PDE1B) and PDE10A are dual-specificity PDEs that hydrolyse both cyclic adenosine monophosphate and cyclic guanosine monophosphate, and are highly expressed in the striatum.
Mayasah Al-Nema, Anand Gaurav, Ming Tatt Lee, Patrick Okechukwu, Piyarat Nimmanpipug, Vannajan Sanghiran Lee   +5 more
doaj   +4 more sources

Integrative multi-omics analyses identify key genes and elucidate bidirectional regulatory mechanisms in thyroid dysfunction. [PDF]

PLoS ONE
ObjectiveHyperthyroidism and hypothyroidism are globally prevalent endocrine disorders, with their pathogenesis involving multifactorial mechanisms including genetics, immunity, and metabolism.
Yilang Hu, Hong Hu, Lijun Xu, Xuzheng Tang, Chongyu Wang, Zhengyi Lian, Chenyu Xie, Zhiwan Xie, Qingqing Wang   +8 more
doaj   +2 more sources

A Novel PDE10A Inhibitor for Tourette Syndrome and Other Movement Disorders [PDF]

Cells
Background: Tourette syndrome is a neurodevelopmental movement disorder involving basal ganglia dysfunction. PDE10A inhibitors modulate signaling in the striatal basal ganglia nuclei and are thus of interest as potential therapeutics in treating Tourette
Randall D. Marshall, Frank S. Menniti, Mark A. Tepper   +2 more
doaj   +2 more sources

In Silico study of PDE10A inhibitors for schizophrenia: molecular docking, ADMET and DFT analysis [PDF]

Discover Chemistry
Recently, interest in phosphodiesterase 10 A inhibitors has increased for schizophrenia treatment. Medicinal chemists have extensively worked on developing potent PDE10A inhibitors with minimal side effects.
Ashutosh Kharwar, Akanksha Verma, Anjani Kumar Tiwari   +2 more
doaj   +2 more sources

Effects of the Phosphodiesterase 10A Inhibitor MR1916 on Alcohol Self-Administration and Striatal Gene Expression in Post-Chronic Intermittent Ethanol-Exposed Rats [PDF]

Cells
Alcohol use disorder (AUD) requires new neurobiological targets. Problematic drinking involves underactive indirect pathway medium spiny neurons (iMSNs) that subserve adaptive behavioral selection vs.
Luísa B. Bertotto, Dolly Lampson-Stixrud, Anushka Sinha, Nicki K. Rohani, Isabella Myer, Eric P. Zorrilla   +5 more
doaj   +2 more sources

THPP-1 PDE10A inhibitor reverses the cognitive deficits and hyperdopaminergic state in a neurodevelopment model of schizophrenia. [PDF]

Schizophr Res
Uliana DL, Martinez A, Grace AA.
europepmc   +2 more sources

Papaverine, a phosphodiesterase 10A inhibitor, ameliorates quinolinic acid-induced synaptotoxicity in human cortical neurons [PDF]

, 2021
Phosphodiesterase-10A (PDE10A) hydrolyse the secondary messengers cGMP and cAMP, two molecules playing important roles in neurodevelopment and brain functions.
Basappa, S., Bhat, Abid, Chidambaram, Saravana B., Chow, Sharron, Essas, Musthafa M., Guillemin, Gilles J., Heng, Benjamin, Tan, Vanessa   +7 more
core   +1 more source

Early-Onset Movement Disorder Syndrome Caused by Biallelic Variants in PDE1B Encoding Phosphodiesterase 1B. [PDF]

Mov Disord
Abstract Background Breakdown of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in basal ganglia cells through hydrolysis of diesteric bonds, primarily by PDE10A and PDE1B, is essential for normal human movement. While biallelic loss‐of‐function variants in PDE10A are known to cause hyperkinetic movement disorders, the ...
Poleg T, Hadar N, Kristal E, Roberts NY, Dolgin V, Aminov I, Safran A, Agam N, Jean M, Freund O, Sheridan EG, Poulter JA, Thompson ML, Algoos Y, Al-Qahtani S, AlAbdi L, Maddirevula S, Hartill V, Houlden H, Maroofian R, Nahum A, Birk OS.   +21 more
europepmc   +2 more sources

PDE10A Inhibitors—Clinical Failure or Window Into Antipsychotic Drug Action?

Frontiers in Neuroscience, 2021
PDE10A, a phosphodiesterase that inactivates both cAMP and cGMP, is a unique signaling molecule in being highly and nearly exclusively expressed in striatal medium spiny neurons.
Frank S. Menniti, Thomas A. Chappie, Christopher J. Schmidt   +2 more
doaj   +1 more source

Discovery of a highly specific 18F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination

Acta Pharmaceutica Sinica B, 2022
As a member of cyclic nucleotide phosphodiesterase (PDE) enzyme family, PDE10A is in charge of the degradation of cyclic adenosine (cAMP) and guanosine monophosphates (cGMP). While PDE10A is primarily expressed in the medium spiny neurons of the striatum,
Zhiwei Xiao, Huiyi Wei, Yi Xu, Ahmed Haider, Junjie Wei, Shiyu Yuan, Jian Rong, Chunyu Zhao, Guocong Li, Weibin Zhang, Huangcan Chen, Yuefeng Li, Lingling Zhang, Jiyun Sun, Shaojuan Zhang, Hai-Bin Luo, Sen Yan, Qijun Cai, Lu Hou, Chao Che, Steven H. Liang, Lu Wang   +21 more
doaj   +1 more source