Results 21 to 30 of about 4,135 (194)

Multi‐domain cognitive resilience to Alzheimer's Disease, Lewy Body and TDP‐43 neuropathologies [PDF]

Alzheimers Dement
Abstract Background To identify cell type‐specific transcriptional signatures of cognitive resilience against neuropathologies in Alzheimer's Disease, Lewy Body and TDP‐43. Methods We used publicly available single nucleus RNA‐seq from the dorsolateral prefrontal cortex of 424 individuals to model the relationship between cell type‐specific gene ...
Luquez T, Sreenivas D, Bennett D, Jager P, Menon V.   +4 more
europepmc   +2 more sources

Phosphodiesterase 10A (PDE10A) as a novel target to suppress β-catenin and RAS signaling in epithelial ovarian cancer

Journal of Ovarian Research, 2022
A leading theory for ovarian carcinogenesis proposes that inflammation associated with incessant ovulation is a driver of oncogenesis. Consistent with this theory, nonsteroidal anti-inflammatory drugs (NSAIDs) exert promising chemopreventive activity for
Rebecca M. Borneman, Elaine Gavin, Alla Musiyenko, Wito Richter, Kevin J. Lee, David K. Crossman, Joel F. Andrews, Annelise M. Wilhite, Steven McClellan, Ileana Aragon, Antonio B. Ward, Xi Chen, Adam B. Keeton, Kristy Berry, Gary A. Piazza, Jennifer M. Scalici, Luciana Madeira da Silva   +16 more
doaj   +1 more source

Striatal phosphodiesterase 10A availability is altered secondary to chronic changes in dopamine neurotransmission

EJNMMI Radiopharmacy and Chemistry, 2016
Background Phosphodiesterase 10A (PDE10A) is an important regulator of nigrostriatal dopamine (DA) neurotransmission. However, little is known on the effect of alterations in DA neurotransmission on PDE10A availability. Here, we used [18F]JNJ42259152 PET
Maarten Ooms, Sofie Celen, Ronald De Hoogt, Ilse Lenaerts, Johnny Liebregts, Greet Vanhoof, Xavier Langlois, Andrey Postnov, Michel Koole, Alfons Verbruggen, Koen Van Laere, Guy Bormans   +11 more
doaj   +1 more source

Comparison of [11C]TZ1964B and [18F]MNI659 for PET imaging brain PDE10A in nonhuman primates [PDF]

, 2016
Phosphodiesterase 10A (PDE10A) inhibitors show therapeutic effects for diseases with striatal pathology. PET radiotracers have been developed to quantify in vivo PDE10A levels and target engagement for therapeutic interventions. The aim of this study was
Alagille, David, Flores, Hubert, Han, Junbin, Jin, Hongjun, Liu, Hui, Perlmutter, Joel S, Su, Yi, Tamagnan, Gilles, Tu, Zhude, Yang, Hao, Yue, Xuyi   +10 more
core   +2 more sources

Radiosynthesis and Radiotracer Properties of a 7-(2-[18F]Fluoroethoxy)-6-methoxypyrrolidinylquinazoline for Imaging of Phosphodiesterase 10A with PET

Pharmaceuticals, 2012
Phosphodiesterase 10A (PDE10A) is a key enzyme of intracellular signal transduction which is involved in the regulation of neurotransmission. The molecular imaging of PDE10A by PET is expected to allow a better understanding of physiological and ...
Detlef Briel, Peter Brust, Achim Hiller, Gregor Schwan, Aurélie Maisonial, Matthias Scheunemann, Steffen Fischer, Winnie Deuther-Conrad, Uta Funke   +8 more
doaj   +1 more source

Characterization of binding and inhibitory properties of TAK-063, a novel phosphodiesterase 10A inhibitor. [PDF]

PLoS ONE, 2015
Phosphodiesterase 10A (PDE10A) inhibition is a novel and promising approach for the treatment of central nervous system disorders such as schizophrenia and Huntington's disease.
Akina Harada, Kazunori Suzuki, Naomi Kamiguchi, Maki Miyamoto, Kimio Tohyama, Kosuke Nakashima, Takahiko Taniguchi, Haruhide Kimura   +7 more
doaj   +1 more source

Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke [PDF]

, 2014
Aims: Cerebral small vessel disease (SVD) causes a fifth of all strokes plus diffuse brain damage leading to cognitive decline, physical disabilities and dementia.
Bailey, Emma L., Crawford, Wendy, Dominiczak, Anna F., Graham, Delyth, McBride, Martin W., McClure, John D., Smith, Colin, Sudlow, Cathie L.M., Wardlaw, Joanna M.   +8 more
core   +2 more sources

Phosphodiesterase type 10A inhibitor attenuates lung fibrosis by targeting myofibroblast activation

iScience, 2023
Summary: Pulmonary fibrosis (PF) is a fatal and irreversible respiratory disease accompanied by excessive fibroblast activation. Previous studies have suggested that cAMP signaling pathway and cGMP-PKG signaling pathway are continuously down-regulated in
Ya-Jun Li, Jian-Rong Shi, Shu-Chan Li, Lu-Ming Wang, Rana Dhar, Ning Li, Xin-Wei Cao, Zi-Gang Li, Hui-Fang Tang   +8 more
doaj   +1 more source

Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error [PDF]

, 2016
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if ...
Amin, Najaf, Barathi, Veluchamy A, Bellenguez, Celine, Blettner, Maria, Boh, Eileen Tai-Hui, Burdon, Kathryn Penelope, Campbell, Harry, Consortium, Refractive Error and Myopia (CREAM), Cougnard-Gregoire, Audrey, Craig, Jamie E, Delcourt, Cecile, et. al., Evans, David M, Fan, Qiao, Fogarty, Rhys Daniel, Gharahkhani, Puya, Gieger, Christian, Guggenheim, Jeremy A, Guo, Xiaobo, Gupta, Preeti, Haller, Toomas, Hewitt, Alex W, Ho, Candice E H, Hofman, Albert, Hohn, Rene, Hosseini, S Mohsen, Huffman, Jenifer E, Hysi, Pirro, Igo, Robert P, Ikram, M Kamran, Joshi, Peter K, Kahonen, Mika, Khawaja, Anthony, Lehtimaki, Terho, Lim, Wan'e, Lu, Yi, Mazur, Johanna, McMahon, George, Meitinger, Thomas, Mirshahi, Alireza, Miyake, Masahiro, Pirastu, Mario, Polasek, Ozren, Portas, Laura, Raitakari, Olli, Ried, Janina S, Rivadeneira, Fernando, Rudan, Igor, Sabanayagam, Charumathi, Schwantes-An, Tae-Hwi, Seppala, Ilkka, Simpson, Claire L, St Pourcain, Beate, Tan, Vincent, Uitterlinden, Andre G, van Leeuwen, Elisabeth M, Vatavuk, Zoran, Venturini, Cristina, Verhoeven, Virginie J M, Vingerling, Johannes R, Vitart, Veronique, Wang, Xu, Wang, Ya Xing, Wedenoja, Juho, Williams, Katie M, Wilson, James F, Wojciechowski, Robert, Xie, Jing, Yamashiro, Kenji, Zeller, Tanja, Zhou, Lei   +70 more
core   +1 more source

Discovery of highly selective and orally available benzimidazole-based phosphodiesterase 10 inhibitors with improved solubility and pharmacokinetic properties for treatment of pulmonary arterial hypertension

Acta Pharmaceutica Sinica B, 2020
Optimization efforts were devoted to discover novel PDE10A inhibitors in order to improve solubility and pharmacokinetics properties for a long-term therapy against pulmonary arterial hypertension (PAH) starting from the previously synthesized inhibitor ...
Yuncong Yang, Sirui Zhang, Qian Zhou, Chen Zhang, Yuqi Gao, Hao Wang, Zhe Li, Deyan Wu, Yinuo Wu, Yi-You Huang, Lei Guo, Hai-Bin Luo   +11 more
doaj   +1 more source