Proteome Analysis of Thyroid Hormone Transporter Mct8/Oatp1c1-Deficient Mice Reveals Novel Dysregulated Target Molecules Involved in Locomotor Function [PDF]
Cells, 2023 Thyroid hormone (TH) transporter MCT8 deficiency causes severe locomotor disabilities likely due to insufficient TH transport across brain barriers and, consequently, compromised neural TH action.
Devon Siemes +9 more
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Striatum‐ and testis‐specific phosphodiesterase PDE10A [PDF]
European Journal of Biochemistry, 1999 PDE10A, a phosphodiesterase (PDE) exhibiting properties of a cAMP PDE and a cAMP‐inhibited cGMP PDE, was cloned and investigated in detail in rats. PDE10A transcripts were abundant in the brain and testis. In situ hybridization analysis using a PDE10A riboprobe demonstrated the presence of PDE10A transcripts in the neurons of the striatum and the ...
Kotomi Fujishige +2 more
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Radiation dosimetry of [11C]TZ1964B as determined by whole-body PET imaging of nonhuman primates [PDF]
EJNMMI ResearchBackground Phosphodiesterase 10A (PDE10A) is a postsynaptic, membrane bound cyclic nucleotide phosphodiesterase that is highly enriched in the striatal medium spiny neurons and regulates dopaminergic neurotransmission.
Baijayanta Maiti +10 more
doaj +2 more sources
Neurobiology of Disease, 2011 Loss of dopamine neurons in experimental parkinsonism results in altered cyclic nucleotide cAMP and cGMP levels throughout the basal ganglia. Our objective was to examine whether expression of phosphodiesterase 10A (PDE10A), an isozyme presenting a ...
M. Giorgi +8 more
doaj +6 more sources
Pivotal role of PDE10A in the integration of dopamine signals in mice striatal D1 and D2 medium-sized spiny neurones [PDF]
bioRxiv, 2021 Dopamine in the striatum plays a crucial role in reward processes and action selection. Dopamine signals are transduced by D1 and D2 dopamine receptors which trigger mirror effects through the cAMP/PKA signalling cascade in D1 and D2 medium-sized spiny ...
Élia Mota +4 more
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PDE10A mutations help to unwrap the neurobiology of hyperkinetic disorders [PDF]
Cellular Signalling, 2019 The dual-specific cAMP/cGMP phosphodiesterase PDE10A is exclusively localised to regions of the brain and specific cell types that control crucial brain circuits and behaviours. The downside to this expression pattern is that PDE10A is also positioned to
Baillie, George S. +3 more
core +5 more sources
bioRxivFerroptosis, an iron-dependent form of cell death, plays a key role in various diseases, but its impact on immune cells, particularly macrophages, remains unclear.
Bradford C. Berk +2 more
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Motor, epileptic, and developmental phenotypes in genetic disorders affecting G protein coupled receptors-cAMP signaling [PDF]
Frontiers in Neurology, 2022 Over the last years, a constantly increasing number of genetic diseases associated with epilepsy and movement disorders have been recognized. An emerging group of conditions in this field is represented by genetic disorders affecting G-protein-coupled ...
Serena Galosi +6 more
doaj +3 more sources
Effects of the Phosphodiesterase 10A Inhibitor MR1916 on Alcohol Self-Administration and Striatal Gene Expression in Post-Chronic Intermittent Ethanol-Exposed Rats [PDF]
CellsAlcohol use disorder (AUD) requires new neurobiological targets. Problematic drinking involves underactive indirect pathway medium spiny neurons (iMSNs) that subserve adaptive behavioral selection vs.
Luísa B. Bertotto +5 more
doaj +2 more sources
Structural insight into the lead identification of a dual inhibitor of PDE1B and PDE10A: Integrating pharmacophore-based virtual screening, molecular docking, and structure-activity-relationship approaches. [PDF]
HeliyonSoon CW, Gaurav A, Gautam V, Al-Nema M.
europepmc +2 more sources