Results 31 to 40 of about 4,135 (194)

Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling. [PDF]

PLoS ONE, 2011
Phosphodiesterases (PDEs) modulate the cellular proliferation involved in the pathophysiology of pulmonary hypertension (PH) by hydrolyzing cAMP and cGMP. The present study was designed to determine whether any of the recently identified PDEs (PDE7-PDE11)
Xia Tian, Christina Vroom, Hossein Ardeschir Ghofrani, Norbert Weissmann, Ewa Bieniek, Friedrich Grimminger, Werner Seeger, Ralph Theo Schermuly, Soni Savai Pullamsetti   +8 more
doaj   +1 more source

Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa. [PDF]

PLoS ONE, 2016
In mammals, adenosine 3', 5'-cyclic monophosphate (cAMP) is known to play highly important roles in sperm motility and acrosomal exocytosis. It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide ...
Serge Goupil, Loïze Maréchal, Hassan El Hajj, Marie-Ève Tremblay, François J Richard, Pierre Leclerc   +5 more
doaj   +1 more source

Inhibition of the striatal specific phosphodiesterase PDE10A ameliorates striatal and cortical pathology in R6/2 mouse model of Huntington's disease. [PDF]

PLoS ONE, 2010
BackgroundHuntington's disease is a devastating neurodegenerative condition for which there is no therapy to slow disease progression. The particular vulnerability of striatal medium spiny neurons to Huntington's pathology is hypothesized to result from ...
Carmela Giampà, Daunia Laurenti, Serenella Anzilotti, Giorgio Bernardi, Frank S Menniti, Francesca Romana Fusco   +5 more
doaj   +1 more source

Phosphodiesterase Inhibition Increases Striatal GDNF and Protects Against Preclinical Parkinsonism. [PDF]

J Neurochem
Parkinson's disease (PD) involves the progressive death of dopamine‐secreting neurons. This research investigates the neuroprotective role of the pharmacological inhibition of phosphodiesterases (PDE) by Ibudilast. This drug elevates levels of the signaling molecule cAMP, which boosts the production of GDNF, a potent neuroprotective factor naturally ...
d'Anglemont de Tassigny X, Jiménez-Medina A, López-López I, López-Barneo J.   +3 more
europepmc   +2 more sources

Replication confirms the association of loci in FOXE1, PDE8B, CAPZB and PDE10A with thyroid traits:a Genetics of Diabetes Audit and Research Tayside study [PDF]

, 2017
Objective: Replication of associations in genome-wide association studies is desirable to ensure that such signals are potentially clinically meaningful.
Doney, Alex S., Leese, Graham P, Palmer, Colin N. A., Pearson, Ewan R., Siddiqui, Moneeza K., Soto-Pedre, Enrique   +5 more
core   +2 more sources

Emerging targets for addiction neuropharmacology: From mechanisms to therapeutics [PDF]

, 2016
Drug abuse represents a considerable burden of disease and has enormous economic impacts on societies. Over the years, few medications have been developed for clinical use. Their utilization is endowed with several limitations, including partial efficacy
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core   +1 more source

Dystonia: sparse synapses for D2 receptors in striatum of a DYT1 knock-out mouse model [PDF]

, 2020
Dystonia pathophysiology has been partly linked to downregulation and dysfunction of dopamine D2 receptors in striatum. We aimed to investigate the possible morpho-structural correlates of D2 receptor downregulation in the striatum of a DYT1 Tor1a mouse ...
Biagioni, S., Cardarelli, S., D'angelo, V., Fusco, F. R., Giorgi, M., Mercuri, N. B., Paldino, E., Sancesario, G., Sorge, R.   +8 more
core   +1 more source

Dopamine D1, D2 and mu-opioid receptors are co-expressed with adenylyl cyclase 5 and phosphodiesterase 7B mRNAs in striatal rat cells [PDF]

, 2013
El pdf es la versión post-print.Intracellular cAMP levels are regulated by cAMP synthesis and degradation rate. Nine isoforms of cAMP-synthesizing enzymes called adenylyl-cyclases (ACs) and eleven phosphodiesterases (PDEs) that degrade cyclic nucleotides
Griesshammer, Martin, Koschmieder, Steffen, Lengfelder, Eva   +2 more
core   +1 more source

Phosphodiesterase 10A (PDE10A) localization in the R6/2 mouse model of Huntington's disease

Neurobiology of Disease, 2013
In Huntington's disease (HD) mutant huntingtin protein impairs the function of several transcription factors, in particular the cAMP response element-binding protein (CREB).
Alessandro Leuti, Daunia Laurenti, Carmela Giampà, Elena Montagna, Clemente Dato, Serenella Anzilotti, Mariarosa A.B. Melone, Giorgio Bernardi, Francesca R. Fusco   +8 more
doaj   +1 more source

Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders. [PDF]

, 2017
The complexity of the traumatic brain injury (TBI) pathology, particularly concussive injury, is a serious obstacle for diagnosis, treatment, and long-term prognosis. Here we utilize modern systems biology in a rodent model of concussive injury to gain a
Agrawal, Rahul, Gomez-Pinilla, Fernando, Meng, Qingying, Yang, Xia, Ying, Zhe, Zhuang, Yumei   +5 more
core   +2 more sources