Results 31 to 40 of about 4,657 (257)

Comparative analysis of PDE10A isoforms [PDF]

BMC Pharmacology, 2011
Phosphodiesterases (PDE) are considered to be key players in many signal transduction pathways. They degrade the second messengers cGMP and cAMP, thereby controlling their intracellular levels. So far, eleven PDE families, typically having several isoforms and splice variants are known.
Corina Russwurm, Ronald Jäger, Doris Koesling, Michael Russwurm   +3 more
openalex   +4 more sources

Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase [PDF]

Neuroscience, 2006
PDE10A is a recently identified phosphodiesterase that is highly expressed by the GABAergic medium spiny projection neurons of the mammalian striatum. Inhibition of PDE10A results in striatal activation and behavioral suppression, suggesting that PDE10A inhibitors represent a novel class of antipsychotic agents.
Zhi Xie, Wendy O. Adamowicz, William D. Eldred, Amy Jakowski, Robin J. Kleiman, Daniel Morton, Diane Stephenson, Christine A. Strick, Robert D. Williams, Frank S. Menniti   +9 more
openalex   +4 more sources

Genomic characterization of individuals presenting extreme phenotypes of high and low risk to develop tobacco‐induced lung cancer [PDF]

Cancer Medicine, 2018
Single nucleotide polymorphisms (SNPs) may modulate individual susceptibility to carcinogens. We designed a genome‐wide association study to characterize individuals presenting extreme phenotypes of high and low risk to develop tobacco‐induced non‐small ...
Juan Pablo Fusco, Guillermo Pita, María José Pajares, Maria Pilar Andueza, Ana Patiño‐García, Juan P. de‐Torres, Alfonso Gurpide, Javier Zulueta, Rosario Alonso, Nuria Alvarez, Ruben Pio, Ignacio Melero, Miguel F. Sanmamed, Maria Rodriguez Ruiz, Ignacio Gil‐Bazo, Jose María Lopez‐Picazo, Ciro Casanova, Rebeca Baz Davila, Antonio Agudo, Maria Dolores Lozano, Alvaro Gonzalez, Nuria Sala, Eva Ardanaz, Javier Benitez, Luis Montuenga, Anna Gonzalez‐Neira, Jose Luis Perez‐Gracia   +26 more
doaj   +2 more sources

Correction to: Role of PDE10A in vascular smooth muscle cell hyperplasia and pathological vascular remodelling

Cardiovascular Research, 2022
Lingfeng Luo, Yujun Cai, Yishuai Zhang, Chia George Hsu, Vyacheslav A. Korshunov, Xiaochun Long, Peter A. Knight, Bradford C. Berk, Yan Chen   +8 more
openalex   +3 more sources

Replication confirms the association of loci in FOXE1, PDE8B, CAPZB and PDE10A with thyroid traits:a Genetics of Diabetes Audit and Research Tayside study [PDF]

, 2017
Doney, Alex S., Leese, Graham P, Palmer, Colin N. A., Pearson, Ewan R., Siddiqui, Moneeza K., Soto-Pedre, Enrique   +5 more
core   +3 more sources

Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a

Nature Neuroscience, 2018
Genetic analyses have linked microRNA-137 (MIR137) to neuropsychiatric disorders, including schizophrenia and autism spectrum disorder. miR-137 plays important roles in neurogenesis and neuronal maturation, but the impact of miR-137 loss-of-function in ...
Ying Cheng, Zhimeng Wang, Theresa May Chin Tan, Xiaona Wang, Yujing Li, Bing Bai, Yuxin Li, Shuang-Feng Zhang, Hailiang Yan, Zuo-Lun Chen, Chang‐Mei Liu, Ting‐Wei Mi, Shuting Xia, Zikai Zhou, An Liu, Guping Tang, Cong Liu, Zhijie Dai, Yingying Wang, Hong Wang, Xusheng Wang, Yunhee Kang, Li Lin, Zhenping Chen, Nina Xie, Qinmiao Sun, Wei Xie, Junmin Peng, Dahua Chen, Zhao‐Qian Teng, Peng Jin   +30 more
openalex   +3 more sources

THPP-1 PDE10A inhibitor reverses the cognitive deficits and hyperdopaminergic state in a neurodevelopment model of schizophrenia

Schizophrenia Research
Daniela L. Uliana, Ángela Martínez, Anthony A. Grace   +2 more
openalex   +2 more sources

Effects of a PDE10A inhibitor and PDE10A2 deficiency on voluntary alcohol intake in mice

Alcohol, 2023
Luísa Becker Bertotto, Satish Ranjan, A.G. Ghoogasian, Gustavo Guerino Macedo, Anastasia E. Pimentel, Chelsea Cates‐Gatto, Amanda J. Roberts, Eric P. Zorrilla   +7 more
openalex   +2 more sources

Phosphodiesterases PDE2A and PDE10A both change mRNA expression in the human brain with age, but only PDE2A changes in a region-specific manner with psychiatric disease

Cellular Signalling, 2020
Reagan Farmer, Steven D. Burbano, Neema S. Patel, Angelo Sarmiento, Abigail J. Smith, Michy P. Kelly   +5 more
openalex   +3 more sources

Phosphodiesterase 10A Inhibitor Modulates Right Ventricular Outflow Tract Electrophysiological Activities and Calcium Homeostasis via the cGMP/PKG Pathway. [PDF]

J Cell Mol Med
ABSTRACT Phosphodiesterase inhibitors regulate intracellular Ca2+ of cardiomyocytes through enhancing second messenger signalling. This study aimed to investigate whether TP‐10, a selective phosphodiesterase10A inhibitor, modulates Ca2+ cycling, attenuating arrhythmogenesis in the right ventricular outflow tract (RVOT).
Lin FZ, Chen YC, Yang HY, Lin WS, Lu YY.
europepmc   +2 more sources