Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder [PDF]
, 2012 Major depressive disorder (MDD) is a common psychiatric illness characterized by low mood and loss of interest in pleasurable activities. Despite years of effort, recent genome-wide association studies (GWAS) have identified few susceptibility variants ...
A Demirkan +52 more
core +7 more sources
Stem Cells International, 2020 Bone marrow-derived mesenchymal stromal cells (hMSCs) are capable of differentiating into the osteogenic lineage, and for osteogenic differentiation, mechanical loading is a relevant stimulus.
Sigrid Müller-Deubert +7 more
doaj +1 more source
Underlying mechanisms of phosphodiesterase 10A and glutamate-ammonia ligase genes that regulate inosine monophosphate deposition and thereby affect muscle tenderness in Jingyuan chickens [PDF]
Animal Bioscience, 2022 Objective Inosine monophosphate (IMP) is a key factor that imparts of meat flavor. Differences in the IMP content in the muscles were evaluated to improve chicken meat quality.
Weizhen Wang +8 more
doaj +1 more source
a study to discover novel tumor-specific mutations [PDF]
, 2015 Background Splenic marginal zone lymphoma (SMZL) is an indolent B-cell non- Hodgkin lymphoma and represents the most common primary malignancy of the spleen. Its precise molecular pathogenesis is still unknown and specific molecular markers for diagnosis
Biskup, Saskia +12 more
core +1 more source
A novel thermoregulatory role for PDE10A in mouse and human adipocytes
EMBO Molecular Medicine, 2016 Phosphodiesterase type 10A (PDE10A) is highly enriched in striatum and is under evaluation as a drug target for several psychiatric/neurodegenerative diseases.
Mohammed K Hankir +17 more
doaj +1 more source
Novel differentially expressed genes and multiple biological pathways for Alzheimer's disease identified in brain tissue from African American donors. [PDF]
Alzheimers DementAbstract INTRODUCTION Few African American (AA) donors have been included in post mortem Alzheimer's disease (AD) studies compared to European‐ancestry (EA) individuals. METHODS We generated transcriptome‐wide bulk pre‐frontal cortex (PFC) gene expression data from 125 AA donors with neuropathologically determined AD and 82 AA controls.
Logue MW +25 more
europepmc +2 more sources
Inhibition of phosphodiesterase10A attenuates morphine-induced conditioned place preference [PDF]
, 2014 Background Phosphodiesterase (PDE) 10A is selectively expressed in medium spiny neurons of the striatum. Nucleus accumbens (NAc) is a key region that mediates drug reward and addiction-related behaviors. To investigate the potential role of PDE10A in the
Bo Gao +7 more
core +3 more sources
Neural substrates and potential treatments for levodopa-induced dyskinesias in Parkinson's disease [PDF]
, 2016 Parkinson’s disease (PD) is primarily a motor disorder that involves the gradual loss of motor function. Symptoms are observed initially in the extremities, such as hands and arms, while advanced stages of the disease can effect blinking, swallowing ...
Eissa, AM +6 more
core +1 more source
Cyclic AMP signalling in pancreatic islets [PDF]
, 2010 Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Furman, Brian +2 more
core +1 more source
Targets for future clinical trials in Huntington's disease: What's in the pipeline? [PDF]
, 2014 The known genetic cause of Huntington's disease (HD) has fueled considerable progress in understanding its pathobiology and the development of therapeutic approaches aimed at correcting specific changes linked to the causative mutation.
Tabrizi, SJ, Wild, EJ
core +1 more source