Results 51 to 60 of about 4,135 (194)

HPRT-deficiency dysregulates cAMP-PKA signaling and phosphodiesterase 10A expression: mechanistic insight and potential target for Lesch-Nyhan Disease? [PDF]

PLoS ONE, 2013
Lesch-Nyhan Disease (LND) is the result of mutations in the X-linked gene encoding the purine metabolic enzyme, hypoxanthine guanine phosphoribosyl transferase (HPRT). LND gives rise to severe neurological anomalies including mental retardation, dystonia,
Ghiabe-Henri Guibinga, Fiona Murray, Nikki Barron   +2 more
doaj   +1 more source

Whole exome sequencing of microdissected splenic marginal zone lymphoma: a study to discover novel tumor-specific mutations [PDF]

, 2015
BACKGROUND: Splenic marginal zone lymphoma (SMZL) is an indolent B-cell non-Hodgkin lymphoma and represents the most common primary malignancy of the spleen. Its precise molecular pathogenesis is still unknown and specific molecular markers for diagnosis
Claudia Döring, Dirk Walter, Franziska Wolters, Jan Peveling-Oberhag, Ludger Sellmann, Marco Lucioni, Marco Paulli, Martin-Leo Hansmann, Max Schubach, Ralf Küppers, René Scholtysik, Saskia Biskup, Stefan Zeuzem   +12 more
core   +3 more sources

Phosphodiesterase 10A Inhibition Modulates the Corticostriatal Activity and L-DOPA-Induced Dyskinesia

Pharmaceuticals, 2022
The facilitation of corticostriatal transmission is modulated by the pharmacological inhibition of striatal phosphodiesterase 10A (PDE10A). Since L-DOPA-induced dyskinesia is associated with abnormal corticostriatal transmission, we hypothesized that ...
Rayanne Poletti Guimarães, Danilo Leandro Ribeiro, Keila Bariotto Dos Santos, Carlos Henrique Zanello Talarico, Lívea Dornela Godoy, Fernando E. Padovan-Neto   +5 more
doaj   +1 more source

Easily automated radiosynthesis of [18F]P10A-1910 and its clinical translation to quantify phosphodiesterase 10A in human brain

Frontiers in Bioengineering and Biotechnology, 2022
Our previous work showed that [18F]P10A-1910 was a potential radioligand for use in imaging phosphodiesterase 10A (PDE10A). Specifically, it had high brain penetration and specific binding that was demonstrated in both rodents and non-human primates ...
Huiyi Wei, Junjie Wei, Shaojuan Zhang, Shiliang Dong, Guocong Li, Wenqing Ran, Chenchen Dong, Weibin Zhang, Chao Che, Wenzhao Luo, Hao Xu, Zhiyong Dong, Zhiyong Dong, Jinghao Wang, Jinghao Wang, Lu Wang, Lu Wang   +16 more
doaj   +1 more source

Tolerance to paradoxical increase in motor activity caused by inhibition of phosphodiesterase 10a in a model of hypodopaminergy

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова
Introduction. Phosphodiesterases (PDEs) are a group of enzymes that hydrolyze the phosphodiester bond in cyclic nucleotides. PDE10A is mainly present in the medium-sized spiny neurons of the striatum.
A. R. Dorotenko, I. M. Sukhanov, A. A. Savchenko, O. A. Dravolina, I. V. Belozertseva   +4 more
doaj   +1 more source

Correspondence: debating China's rise and the future of U.S. power [PDF]

, 2016
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide and the most common movement disorder. A defining pathologic feature of PD is the progressive death of dopaminergic neurons in a basal ganglia nucleus termed the ...
Wang, William Z.Y., Brooks, Stephen G., Wohlforth, William C.   +2 more
core   +2 more sources

An Erythropoietin-Independent Mechanism of Erythrocytic Precursor Proliferation Underlies Hypoxia Tolerance in Sea Nomads

Frontiers in Physiology, 2022
The Bajau Sea Nomads were recently demonstrated to have evolved larger spleens as an adaptation to millennia of a marine foraging lifestyle. The large-spleen phenotype appears to derive from increases in thyroid hormone (TH) production as a result of ...
Melissa Ilardo, Melissa Ilardo, Maria C. Ferreira dos Santos, Niels Grote Beverborg, Malini Rajan, M. Abdullah Said, Niek Verweij, Pim Van Der Harst, Peter Van Der Meer, Elizabeth A. Leibold   +9 more
doaj   +1 more source

Cognitive Dysfunction in Huntington's Disease: Mechanisms and Therapeutic Strategies Beyond BDNF [PDF]

, 2016
One of the main focuses in Huntington's disease (HD) research, as well as in most of the neurodegenerative diseases, is the development of new therapeutic strategies, as currently there is no treatment to delay or prevent the progression of the disease ...
Abel, Alarcon, Alberch, Andre, Apostol, Arregui, Backman, Baquet, Barco, Barrett, Bates, Begeti, Behr, Bender, Benito, Berrios, Bezprozvanny, Bezprozvanny, Bibb, Bibel, Bliss, Blokland, Boll, Boolell, Bourtchouladze, Bourtchuladze, Bowles, Brito, Brito, Brooks, Brooks, Brooks, Brooks, Brooks, Brooks, Brooks, Buren, Burgess, Cahill, Caramins, Carter, Ceni, Cepeda, Cepeda, Cepeda, Cepeda, Cepeda, Chan, Chang, Chaturvedi, Chen, Chiba, Chrivia, Clarke, Colomer, Coulson, Cummings, Cummings, Cummings, Cummings, Cybulska-Klosowicz, Davies, Deckel, Deckel, Deckel, Deng, Desplats, Di, Diaz-Hernandez, DiFiglia, Dubnau, Dumas, Ehrnhoefer, Eichenbaum, Eichenbaum, Estrada-Sanchez, Estrada-Sanchez, Fan, Fan, Fan, Ferrante, Ferrante, Ferrer, Ferreri, Fossale, Friedman, Gafni, Gardian, Gharami, Ghilan, Giampa, Giampa, Gines, Gines, Gines, Gines, Giralt, Giralt, Giralt, Giralt, Giralt, Giralt, Gladding, Gonzales, Gorski, Graveland, Gray, Greferath, Gruart, Gu, Gu, Hahn-Barma, Harrington, Hebb, Heck, Heckman, Herndon, Hickey, Ho, Hodges, Hodgson, Hong, Hult, Ille, Jarabek, Jia, Jia, Jiang, Joshi, Kalkhoven, Kandel, Kandel, Kandel, Kassubek, Kehoe, Kelly, Kennedy, Kessels, Killoran, Kim, Klapstein, Kleiman, Kleppisch, Korzus, Kumar, Kwok, Labbadia, Laforet, Lawrence, Lawrence, Lawrence, Lee, Lee, Lee, Lee, Lemiere, Lerner, Levine, Levine, Li, Li, Li, Li, Li, Lin, Lione, Lonze, Lonze, Lu, Luthi-Carter, Luthi-Carter, Lynch, Lynch, Ma, Ma, MacPhee, Mangiarini, Mansuy, Marco, Marder, Marti, Mayford, Mazarakis, McBride, McCampbell, Meade, Menalled, Menalled, Metzler, Miguez, Miller, Milnerwood, Milnerwood, Milnerwood, Mitsuishi, Montaldi, Montoya, Morton, Morton, Murmu, Murphy, Nguyen, Niccolini, Nithianantharajah, Norris, Nucifora, Numakawa, Ogryzko, Oike, Orth, Padovan-Neto, Paoletti, Papoutsi, Papp, Parker, Parker, Paulsen, Paulsen, Paulsen, Peixoto, Penzes, Penzes, Penzes, Perez-Otano, Perez-Severiano, Pineda, Plotkin, Plotkin, Politis, Poo, Popoli, Popoli, Popugaeva, Poudel, Poudel, Pouladi, Pouladi, Puerta, Puigdellivol, Putney, Puzzo, Raamsdonk, Raamsdonk, Raamsdonk, Raamsdonk, Raamsdonk, Radhakrishnan, Ramaswamy, Ravnskjaer, Raymond, Reiner, Roberts, Rocher, Rosas, Rosas, Rosch, Rosenberg, Rosenfeld, Rossi, Rouaux, Roze, Rue, Runne, Russell, Saavedra, Saavedra, Saavedra, Sadri-Vakili, Sapp, Sapp, Saura, Schaffar, Schilling, Schippling, Schneider, Seo, Sepers, Seredenina, Shepherd, Shirasaki, Silva, Simmons, Siuciak, Skaper, Slow, Smith, Song, Sotrel, Spampanato, Spargo, Spires, Stack, Steffan, Steffan, Stout, Stout, Sugars, Sun, Suopanki, Tang, Tang, Taylor, Thakur, The Huntington's Disease Collaborative Research Group, Thierry, Threlfell, Threlfell, Troy, Trueman, Turmaine, Tyebji, Unschuld, Valor, Vecsey, Verny, Victorson, Vo, Voermans, von Bohlen Und, Vonsattel, Vonsattel, Wang, Wheeler, Wheeler, Wheeler, Wheeler, Wong, Woo, Wood, Wu, Wu, Wu, Xie, Xie, Xifro, Xifro, Xifro, Xu, Yamamoto, Yamashita, Yhnell, Yhnell, Yu, Zagrebelsky, Zakzanis, Zee, Zhang, Zuccato, Zuccato, Zuccato, Zuccato, Zuccato, Zuccato, Zuccato   +353 more
core   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

A PDE10A inhibitor CPL500036 is a novel agent modulating striatal function devoid of most neuroleptic side-effects

Frontiers in Pharmacology, 2022
Background: Phosphodiesterase 10A (PDE10A) is expressed almost exclusively in the striatum and its inhibition is suggested to offer potential treatment in disorders associated with basal ganglia.
Mikolaj Matloka, Sylwia Janowska, Piotr Pankiewicz, Sofiya Kokhanovska, Tomasz Kos, Małgorzata Hołuj, Izabela Rutkowska-Wlodarczyk, Krzysztof Abramski, Monika Janicka, Piotr Jakubowski, Maciej Świątkiewicz, Marlena Welniak-Kaminska, Joanna Hucz-Kalitowska, Paulina Dera, Lukasz Bojarski, Paweł Grieb, Piotr Popik, Maciej Wieczorek, Jerzy Pieczykolan   +18 more
doaj   +1 more source