Pharmaceuticals, 2012 Phosphodiesterase 10A (PDE10A) is a key enzyme of intracellular signal transduction which is involved in the regulation of neurotransmission. The molecular imaging of PDE10A by PET is expected to allow a better understanding of physiological and ...
Detlef Briel +8 more
doaj +1 more source
Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke [PDF]
, 2014 Aims: Cerebral small vessel disease (SVD) causes a fifth of all strokes plus diffuse brain damage leading to cognitive decline, physical disabilities and dementia.
Bailey, Emma L. +8 more
core +2 more sources
Characterization of binding and inhibitory properties of TAK-063, a novel phosphodiesterase 10A inhibitor. [PDF]
PLoS ONE, 2015 Phosphodiesterase 10A (PDE10A) inhibition is a novel and promising approach for the treatment of central nervous system disorders such as schizophrenia and Huntington's disease.
Akina Harada +7 more
doaj +1 more source
Phosphodiesterase type 10A inhibitor attenuates lung fibrosis by targeting myofibroblast activation
iScience, 2023 Summary: Pulmonary fibrosis (PF) is a fatal and irreversible respiratory disease accompanied by excessive fibroblast activation. Previous studies have suggested that cAMP signaling pathway and cGMP-PKG signaling pathway are continuously down-regulated in
Ya-Jun Li +8 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2020 Optimization efforts were devoted to discover novel PDE10A inhibitors in order to improve solubility and pharmacokinetics properties for a long-term therapy against pulmonary arterial hypertension (PAH) starting from the previously synthesized inhibitor ...
Yuncong Yang +11 more
doaj +1 more source
Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling. [PDF]
PLoS ONE, 2011 Phosphodiesterases (PDEs) modulate the cellular proliferation involved in the pathophysiology of pulmonary hypertension (PH) by hydrolyzing cAMP and cGMP. The present study was designed to determine whether any of the recently identified PDEs (PDE7-PDE11)
Xia Tian +8 more
doaj +1 more source
Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error [PDF]
, 2016 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if ...
Amin, Najaf +70 more
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Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa. [PDF]
PLoS ONE, 2016 In mammals, adenosine 3', 5'-cyclic monophosphate (cAMP) is known to play highly important roles in sperm motility and acrosomal exocytosis. It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide ...
Serge Goupil +5 more
doaj +1 more source
Dystonia: sparse synapses for D2 receptors in striatum of a DYT1 knock-out mouse model [PDF]
, 2020 Dystonia pathophysiology has been partly linked to downregulation and dysfunction of dopamine D2 receptors in striatum. We aimed to investigate the possible morpho-structural correlates of D2 receptor downregulation in the striatum of a DYT1 Tor1a mouse ...
Biagioni, S. +8 more
core +1 more source
Underlying mechanisms of phosphodiesterase 10A and glutamate-ammonia ligase genes that regulate inosine monophosphate deposition and thereby affect muscle tenderness in Jingyuan chickens [PDF]
Animal Bioscience, 2022 Objective Inosine monophosphate (IMP) is a key factor that imparts of meat flavor. Differences in the IMP content in the muscles were evaluated to improve chicken meat quality.
Weizhen Wang +8 more
doaj +1 more source