Results 61 to 70 of about 4,135 (194)
The Journal of Physiology, EarlyView.Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani +5 more
wiley +1 more source
Journal of Cheminformatics, 2017 Compounds designed to display polypharmacology may have utility in treating complex diseases, where activity at multiple targets is required to produce a clinical effect.
Leen Kalash +11 more
doaj +1 more source
Quetiapine and novel PDE10A inhibitors potentiate the anti-BuChE activity of donepezil
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 The symptoms of Alzheimer’s disease (AD) do not include only memory loss and cognitive decline but also neuropsychiatric manifestation. These AD-related symptoms are usually treated with the aid of antipsychotics; however, their effects on cognition and ...
Joanna Sikora +7 more
doaj +1 more source
Cells, 2023 Thyroid hormone (TH) transporter MCT8 deficiency causes severe locomotor disabilities likely due to insufficient TH transport across brain barriers and, consequently, compromised neural TH action.
Devon Siemes +9 more
doaj +1 more source
ホスホジエステラーゼ10Aの特異的阻害によるハンチントン病治療の可能性に関する研究 [PDF]
, 2018 筑波大学University of Tsukuba博士（生物科学）Doctor of Philosophy in Biological Science2017【要旨 ...
194578, Harada, Akina, 原田, 晃名
core +1 more source
Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease. [PDF]
, 2018 Huntington's disease (HD) patients suffer from a progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction.
Colwell, Christopher S +5 more
core +1 more source
Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.Single‐nucleus RNA sequencing (snRNA‐seq) maps the cellular diversity of pulmonary sarcomatoid carcinoma (PSC) and primary pulmonary sarcomas (PPS). AT2 cells, a major source of epithelial cells in PSC, underwent malignant transformation primarily through epithelial–mesenchymal transition, suggesting AT2 cells may serve as the origin of PSC.
Jianfei Zhu +11 more
wiley +1 more source
Acetaldehyde as a drug of abuse: Involvement of endocannabinoid- and dopamine neurotransmission [PDF]
, 2014 Acetaldehyde (ACD), the first metabolite of ethanol, directly enhances dopamine neurotransmission (1) and has rewarding and motivational properties in paradigms tailored for studying addictive-like behaviours (2, 3).
BRANCATO, Anna, CANNIZZARO, Carla
core +1 more source
Polydopamine‐Based Antioxidant Countermeasures Against Spaceflight‐Induced Neurodegeneration
Small Science, Volume 6, Issue 1, January 2026.Polydopamine nanoparticles (PDNPs) protect neuron‐like cells from microgravity‐ and cosmic radiation‐induced oxidative stress. Through in‐flight and ground‐based experiments, it has been shown that PDNPs preserve neuronal and mitochondrial function, markedly mitigating transcriptional dysregulation caused by spaceflight.
Alessio Carmignani +10 more
wiley +1 more source
A Robust Gene Expression Prognostic Signature for Overall Survival in High-Grade Serous Ovarian Cancer. [PDF]
, 2019 The objective of this research was to develop a robust gene expression-based prognostic signature and scoring system for predicting overall survival (OS) of patients with high-grade serous ovarian cancer (HGSOC).
Hang, Bo +8 more
core