Emerging targets for addiction neuropharmacology: From mechanisms to therapeutics [PDF]
, 2016 Drug abuse represents a considerable burden of disease and has enormous economic impacts on societies. Over the years, few medications have been developed for clinical use. Their utilization is endowed with several limitations, including partial efficacy
Al-Barazanji +218 more
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a study to discover novel tumor-specific mutations [PDF]
, 2015 Background Splenic marginal zone lymphoma (SMZL) is an indolent B-cell non- Hodgkin lymphoma and represents the most common primary malignancy of the spleen. Its precise molecular pathogenesis is still unknown and specific molecular markers for diagnosis
Biskup, Saskia +12 more
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Multi-locus genome-wide association analysis supports the role of glutamatergic synaptic transmission in the etiology of major depressive disorder [PDF]
, 2012 Major depressive disorder (MDD) is a common psychiatric illness characterized by low mood and loss of interest in pleasurable activities. Despite years of effort, recent genome-wide association studies (GWAS) have identified few susceptibility variants ...
A Demirkan +52 more
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Phosphodiesterase 10A (PDE10A) localization in the R6/2 mouse model of Huntington's disease
Neurobiology of Disease, 2013 In Huntington's disease (HD) mutant huntingtin protein impairs the function of several transcription factors, in particular the cAMP response element-binding protein (CREB).
Alessandro Leuti +8 more
doaj +1 more source
Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders. [PDF]
, 2017 The complexity of the traumatic brain injury (TBI) pathology, particularly concussive injury, is a serious obstacle for diagnosis, treatment, and long-term prognosis. Here we utilize modern systems biology in a rodent model of concussive injury to gain a
Agrawal, Rahul +5 more
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Synthesis of Fluorine-Containing Phosphodiesterase 10A (PDE10A) Inhibitors and the In Vivo Evaluation of F-18 Labeled PDE10A PET Tracers in Rodent and Nonhuman Primate [PDF]
Journal of Medicinal Chemistry, 2015 A series of fluorine-containing PDE10A inhibitors were designed and synthesized to improve the metabolic stability of [(11)C]MP-10. Twenty of the 22 new analogues had high potency and selectivity for PDE10A: 18a-j, 19d-j, 20a-b, and 21b had IC50 values
Junfeng Li +6 more
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Stem Cells International, 2020 Bone marrow-derived mesenchymal stromal cells (hMSCs) are capable of differentiating into the osteogenic lineage, and for osteogenic differentiation, mechanical loading is a relevant stimulus.
Sigrid Müller-Deubert +7 more
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Dopamine D1, D2 and mu-opioid receptors are co-expressed with adenylyl cyclase 5 and phosphodiesterase 7B mRNAs in striatal rat cells [PDF]
, 2013 El pdf es la versión post-print.Intracellular cAMP levels are regulated by cAMP synthesis and degradation rate. Nine isoforms of cAMP-synthesizing enzymes called adenylyl-cyclases (ACs) and eleven phosphodiesterases (PDEs) that degrade cyclic nucleotides
Griesshammer, Martin +2 more
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A novel thermoregulatory role for PDE10A in mouse and human adipocytes
EMBO Molecular Medicine, 2016 Phosphodiesterase type 10A (PDE10A) is highly enriched in striatum and is under evaluation as a drug target for several psychiatric/neurodegenerative diseases.
Mohammed K Hankir +17 more
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Frontiers in Integrative Neuroscience, 2014 Alcohol use disorders are persistent problems with high recidivism rates despite repeated efforts to quit drinking. Neuroadaptations that result from alcohol exposure and that persist during periods of abstinence represent putative molecular ...
Marian L Logrip, Eric P Zorrilla
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