Results 81 to 90 of about 4,135 (194)

Combination of the phosphodiesterase 10A inhibitor, MR1916 with risperidone shows additive antipsychotic‐like effects without affecting cognitive enhancement and cataleptic effects in rats

Neuropsychopharmacology Reports, 2020
Aim Phosphodiesterase 10A (PDE10A) inhibitors not only have antipsychotic‐like effects but also cause cognitive enhancement without affecting extrapyramidal side effects in rodents, suggesting that PDE10A may be a novel approach for the treatment of ...
Keita Arakawa, Shunsuke Maehara
doaj   +1 more source

Effects of subchronic phencyclidine on behaviour of female rats on the elevated plus maze and open field [PDF]

, 2009
YesFemale hooded-Lister rats received either sub-chronic phencyclidine (PCP) (2 mg/kg, n=20) or vehicle (1 ml/kg, n=20) i.p. twice daily for seven days, followed by a seven-day washout period. Rats were challenged with acute PCP or vehicle and tested for
Abekawa, T., JC Neill, ML Woolley, SL McLean   +3 more
core   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

Advanced Science, Volume 12, Issue 42, November 13, 2025.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li   +12 more
wiley   +1 more source

Phosphodiesterase 10A as a Therapeutic Target in Neuropsychopharmacology: A Review

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. Phosphodiesterases (PDEs) are enzymes that regulate intracellular signalling by catalysing the hydrolysis of cyclic nucleotides. The commercial success of selective PDE5 inhibitors for erectile dysfunction and PDE4 inhibitors for ...
A. R. Dorotenko, I. M. Sukhanov, G. V. Iskarevskii, A. S. Ulitina, A. A. Savchenko, M. А. Tur   +5 more
doaj   +1 more source

Targeting PDE10A GAF Domain with Small Molecules: A Way for Allosteric Modulation with Anti-Inflammatory Effects

Molecules, 2017
Phosphodiesterase (PDE) enzymes regulate the levels of cyclic nucleotides, cAMP, and/or cGMP, being attractive therapeutic targets. In order to modulate PDE activity in a selective way, we focused our efforts on the search of allosteric modulators. Based
Ana M. García, José Brea, Alejandro González-García, Concepción Pérez, María Isabel Cadavid, María Isabel Loza, Ana Martinez, Carmen Gil   +7 more
doaj   +1 more source

Mouse models of neurodegenerative disease: preclinical imaging and neurovascular component. [PDF]

, 2018
Neurodegenerative diseases represent great challenges for basic science and clinical medicine because of their prevalence, pathologies, lack of mechanism-based treatments, and impacts on individuals.
A Bellucci, A Bonito-Oliva, A Boroujerdi, A Brockington, A Burgess, A Dorr, A Lockhart, A Manook, A Parievsky, A Rahman, A Rönnbäck, A Snellman, A Vercelli, AB Muñoz-Manchado, AD Kane, Adelaide Greco, AF Martins, AF Mellin, AG Barbeito, AH Jacobs, AI Brooks, AJ Lin, AK Srivastava, AL Brownell, AL Southwell, AM Hall, AP Patterson, AR Varma, AY Lai, B Joglar, B Oosthuyse, B Ott, B Platt, B Schwendele, B Stankoff, B Vastenhouw, BJ Turner, BS Buddeberg, C Bigot, C Casteels, C Cauwenberghe Van, C Cepeda, C Klein, C Procaccini, C Romberg, CA Denny, CA Hawkes, CE Moussa, CG Radu, CI Choi, CJ Macmillan, CY Lin, D Alvarez-Fischer, D Dam Van, D Diorio, D Hare, D Havas, D Liebetanz, D Litteljohn, D McLean, D Paula Faria de, D Rial, DA Shear, DM Iascone, DP McCarthy, DW Luchtman, DW Zang, DW Zang, E Milner, E Rockenstein, E Storkebaum, EK Agyare, EL Oleszak, EM Knight, EM Robbins, F Blandini, F Gilli, F Hébert, F Kara, F Luo, F Luo, F Mattner, FS Roman, G Andringa, G Kreiner, G Poisnel, G Rougon, GD Vickle Van, GE Meredith, GE Woloschak, GF Passos, GL Bowman, H Benveniste, H Brautigam, H Gu, H Li, H Oakley, H Schmalbruch, H Xiong, HB Fernandes, HG Niessen, HJ Newbery, HJ Waldvogel, HK Li-Chun, HV Vinters, HY Hsiao, I Dewachter, I Peruga, I Rattray, IG Kirkinezos, IR Macdonald, J Apelt, J Beauquis, J Boix, J Dorpe Van, J Drouin-Ouellet, J Grandjean, J Hua, J Klohs, J Klohs, J Lengfeld, J Luo, J Mahler, J Pépin, J Zhang, JA Helpern, JC Furtado, JC Glorioso, JD Lee, JE Hanson, JF Poduslo, JF Reilly, JJ Steventon, JK Ryu, JL Berard, JL Jankowsky, JL Lynch, JM Moser, JM Raamsdonk Van, JM Redwine, JP Lerch, JS Lunn, JS Toomey, K Miyazaki, K Miyazaki, K Poesen, KA Jellinger, KJ Bryan, KK Cheng, KK Kandimalla, KL Berggren, KM Jaruszewski, KR Rekha, KR Stover, KS Lindenberg, KS Lowry, KS Montgomery, L Auletta, L Chen, L Giménez-Llort, L Holcomb, L Mao, L Mucke, LA Thomason, LB Tovar-y-Romo, LH Wang, LI Bruijn, LM Gorton, Luigi Auletta, M Aggarwal, M Azzouz, M Baranyi, M Honer, M Knobloch, M Mancini, M Terzioglu, M Tóth, M Ziebell, M-J Lee, MA Busche, MA Hickey, Marcello Mancini, MC Evans, MD Meadowcroft, MD Santin, ML James, ML Starkey, MM Khalil, MM Paz Soldán, MY Heng, N Beckmann, N Nathoo, N Nathoo, NG Spencer, NM Lewandowski, O Philipson, OP Keifer Jr., P Bagga, P Bose, P Dibaj, P Kennel, P Zamboni, PM Switonski, PN Lacor, PO Fernagut, PO Fernagut, PO Fernagut, R Berg Van den, R Betarbet, R Chamberlain, R Chang, R Günther, R Muramatsu, R Zhang, RA Grant, RL Faull, RM Deacon, RM Nicholson, S Acharjee, S Fjær, S Franciosi, S Gargiulo, S George, S Kikuta, S Knippenberg, S Knippenberg, S Kumar-Singh, S Kumar-Singh, S Nessler, S Oddo, S Oddo, S Oliván, S Onida, S Ramaswamy, S Rojas, S Sarkar, S Serres, S Venneti, Sandra Albanese, SD Girard, SJ Sawiak, SJ Teipel, SJ Webster, SK Sharma, SM Fleming, SM Fleming, SR Suwijn, T Arora, T Spires-Jones, T Yamasaki, T Yasuhara, TN Luong, TN Taylor, TN Taylor, TO Abakumova, V Bogaerts, VL Eaton, W Atkinson, W Lin, W Lu, W Xu, WA Roscoe, WL Klein, WT Lee, X Wang, Y Cheng, Y Kishimoto, Y Li, Y Liu, Y Waerzeggers, Y Wei, Y Zhao, Y Zhou, YZ Wadghiri, YZ Wadghiri, Z Zhong   +275 more
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Multi-level evidence of an allelic hierarchy of USH2A variants in hearing, auditory processing and speech/language outcomes. [PDF]

, 2020
Language development builds upon a complex network of interacting subservient systems. It therefore follows that variations in, and subclinical disruptions of, these systems may have secondary effects on emergent language.
1000 Genomes Project C., A Adato, A Boyd, A Gialluisi, A Rimmer, A Van Aarem, A Vouloumanos, AA Benasich, AL Barabasi, BJ Keats, BR Shrestha, C Kilkenny, C Witton, CA Anderson, CC Brewer, CF Norbury, CF Reisser, CS Lai, D Szklarczyk, DF Newbury, DF Newbury, DR Moore, DR Moore, DV Bishop, E Eising, E Lenassi, G Conti-Ramsden, G Dehaene-Lambertz, G Lunter, GR Abecasis, J Golding, J Heckman, J Hornickel, JA Boughman, JC Barrett, JC Taylor, JM Ellingford, K Walter, K Wang, K Watanabe, L Huang, M Kircher, M Lek, M Luciano, M Van Segbroeck, MC Liberman, MEK Niemi, MG Filipe, MJ Henry, MR Bowl, N Pearsall, P Cingolani, P Danecek, P Le Quesne Stabej, R Mora, R Nudel, RH Fitch, RH Fitch, RM Rosenfeld, S Colella, S Lee, S Purcell, S Richards, S Shultz, SW Threlkeld, WJ Kent, WJ Kimberling, X Liu, X Zhan, XS Chen, Y Zhou, Y-M Tien   +71 more
core   +5 more sources

p‐Cymene Targets Multiple Oncogenic Pathways in Hepatocellular Carcinoma: Insights From Network Pharmacology and In Vitro Studies

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
p‐Cymene exhibited a strong affinity for key hepatocellular carcinoma (HCC) targets and induced dose‐dependent cytotoxicity in HepG2 cells while enhancing antioxidant defense mechanisms. The treatment significantly modulated apoptotic and angiogenic markers, notably increasing Caspase‐3 and p53, and suppressing BCL2 and VEGF expression.
Nadia Anwar, Muhammad Nasir Hayat Malik, Muhammad Atif, Abdullah R. Alanzi, Hattan A. Alharbi, Waqas Younis, Munawar Abbas, Gideon F. B. Solre   +7 more
wiley   +1 more source

Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. [PDF]

, 2016
To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat lengths.
A Dobin, A Hodges, A Kuhn, A Pal, A Reiner, A Valencia, Andreas Tebbe, B Zhang, B Zhang, BM Bolstad, C Zuccato, CA Ross, Christoph Schaab, Daniel J Lavery, David Howland, DI Shirasaki, Doxa Chatzopoulou, DV Zaykin, EH Aylward, Eliana Marisa Ramos, ES Deneris, ES Lein, Fuying Gao, G Fishell, GA Smith, Giovanni Coppola, HT Orr, I Al-Ramahi, IS Seong, Ismael Al-Ramahi, J Cox, J Cox, J Labbadia, JA Miller, JC Jacobsen, JE Phillips, Jeffrey P Cantle, Jeffrey S Aaronson, JF Gusella, JF Gusella, Jim Rosinski, JM Dowen, JM Van Raamsdonk, JP Vonsattel, Juan Botas, K Becanovic, K Monahan, K Sharma, Karla El-Zein, LB Menalled, LB Menalled, LB Menalled, LS Kaltenbach, M Biagioli, M Heiman, M MACDONALD, M Mann, M Mielcarek, MA Pouladi, MC Oldham, MI Love, MK Lobo, MT Lin, N Wang, Nan Wang, P Giles, P Grange, P Langfelder, P Langfelder, P Langfelder, P Langfelder, P Langfelder, Peter Langfelder, PF Durrenberger, RC Gentleman, S Anders, S Horvath, S Toyoda, Sandeep Deverasetty, Seung Kwak, Steve Horvath, T Geiger, T Lu, WE Johnson, WV Chen, X Gu, X Gu, X William Yang, XH Lu, Xiao-Hong Lu, Y Benjamini, Y Guo, Y Shen, Y Wang, Yining Zhao   +94 more
core   +1 more source

Recessive Loss of PI4K2A Function Causes a Developmental and Epileptic Dyskinetic Encephalopathy with Prominent Orolingual Dyskinesia

Movement Disorders, Volume 40, Issue 10, Page 2243-2250, October 2025.
Abstract Background Biallelic loss‐of‐function variants in PI4K2A have been associated with a neurodevelopmental disorder characterized by seizures and movement disorders, including orofacial dyskinesia. However, only 4 cases have been reported. Orolingual dyskinesia—defined as involuntary movements of the mouth and tongue—is observed in various ...
Reza Maroofian, Juan Darío Ortigoza‐Escobar, Pooja Rohilla, Javeria Raza Alvi, Aziza M. Mushiba, Naif A.M. Almontashiri, Stephanie Efthymiou, Tipu Sultan, Tamas Balla, Henry Houlden   +9 more
wiley   +1 more source