Results 81 to 90 of about 4,657 (257)
Whole exome sequencing of microdissected splenic marginal zone lymphoma: a study to discover novel tumor-specific mutations [PDF]
, 2015 BACKGROUND: Splenic marginal zone lymphoma (SMZL) is an indolent B-cell non-Hodgkin lymphoma and represents the most common primary malignancy of the spleen. Its precise molecular pathogenesis is still unknown and specific molecular markers for diagnosis Claudia Döring, Dirk Walter, Franziska Wolters, Jan Peveling-Oberhag, Ludger Sellmann, Marco Lucioni, Marco Paulli, Martin-Leo Hansmann, Max Schubach, Ralf Küppers, René Scholtysik, Saskia Biskup, Stefan Zeuzem +12 morecore +3 more sourcesTranslating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies [PDF]
, 2017 The presence and severity of cognitive symptoms, including working memory, executive dysfunction and attentional impairment, contributes materially to functional impairment in schizophrenia.Abdolmaleky, Abe, Alexander, Alexander, Alexander, Alexander, Alexander, Allen, Anagnostaras, Babovic, Bado, Ballard, Barch, Bartko, Basu, Beaulieu, Bogdan, Bugarski-Kirola, Bugarski-Kirola, Burdick, Cannon, Carpenter, Carr, Carter, Chen, Chong, Chong, Chubb, Clapcote, Clifton, CNV and Schizophrenia Working Groups of the Psychiatric Genomics Consortium, Cohen, Cope, Cosgrove, Cui, Cuthbert, Devaraju, Devito, Downing, Duan, Duffy, Dunlop, Egerton, El-Ghundi, Evensen, Falkenberg, Farrell, Fernandes, Freedman, Fromer, Fujioka, Gatt, Genovese, Ghoshal, Glahn, Gogos, Gong, Gonzalez-Burgos, Gottesman, Gould, Grannan, Green, Hahn, Hall, Hall, Harris, Harrison, Harrison, Hennah, Holmes, Hopkins, Howes, Howes, Hoyle, Iacono, Iacono, International Schizophrenia Consortium, Iwakura, Jentsch, Johnson, Johnson, Johnstone, Jonas, Jones, Kaiser, Kao, Karam, Karlsgodt, Kato, Kern, Kinon, Kirov, Kleinman, Kogan, Koike, Krivoy, Krivoy, Kunii, Kvajo, Labrie, Law, Law, Law, Lee, Lencz, Lerner, Lewis, Li, Li, Li, Lieblich, Lin, Lipina, Long, Maric, McCarroll, Meechan, Meechan, Mei, Mexal, Miyakawa, Moore, Moran, Moran, Morris, Mostaid, Muir, Mukai, Munafò, Neddens, Neddens, Nicodemus, Nicodemus, Nong, Nuechterlein, Nuechterlein, O'Tuathaigh, O'Tuathaigh, O'Tuathaigh, Ouchi, Pan, Papaleo, Papaleo, Papaleo, Papaleo, Papaleo, Park, Parlapani, Paterlini, Paterson, Patil, Pei, Petit, Piskorowski, Pletnikov, Porteous, Pratt, Preskorn, Prickaerts, Pritchett, Pritchett, Pull, Rafter, Reynolds, Ribeiz, Rosell, Ruderfer, Sarter, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Schlumberger, Schneider, Schubert, Seamans, Ser, Shekhar, Shiraishi, Shirey, Sigurdsson, Singer, Singer, Singh, Siuta, Southan, Stark, Stauffer, Stefanis, Stroup, Su, Suzuki, Svensson, Takao, Talbot, Talbot, Tamura, Tandon, Tang, Tost, Tunbridge, Turetsky, Urs, Urs, Veerman, Vijayraghavan, Waddington, Walling, Walsh, Walters, Wang, Wang, Weickert, Weickert, Weinberg, Weinstein, Weiser, Winchester, Woolley, Xu, Yee, Young, Young, Young, Young, Young, Young, Young, Zai, Zhang, Zhou +227 morecore +2 more sourcesInhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome
Advanced Science, EarlyView.We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold +8 morewiley +1 more sourceComputer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases
Journal of Cheminformatics, 2017 Compounds designed to display polypharmacology may have utility in treating complex diseases, where activity at multiple targets is required to produce a clinical effect.Leen Kalash, Cristina Val, Jhonny Azuaje, María I. Loza, Fredrik Svensson, Azedine Zoufir, Lewis Mervin, Graham Ladds, José Brea, Robert Glen, Eddy Sotelo, Andreas Bender +11 moredoaj +1 more sourceCognitive Dysfunction in Huntington's Disease: Mechanisms and Therapeutic Strategies Beyond BDNF [PDF]
, 2016 One of the main focuses in Huntington's disease (HD) research, as well as in most of the neurodegenerative diseases, is the development of new therapeutic strategies, as currently there is no treatment to delay or prevent the progression of the disease ...Abel, Alarcon, Alberch, Andre, Apostol, Arregui, Backman, Baquet, Barco, Barrett, Bates, Begeti, Behr, Bender, Benito, Berrios, Bezprozvanny, Bezprozvanny, Bibb, Bibel, Bliss, Blokland, Boll, Boolell, Bourtchouladze, Bourtchuladze, Bowles, Brito, Brito, Brooks, Brooks, Brooks, Brooks, Brooks, Brooks, Brooks, Buren, Burgess, Cahill, Caramins, Carter, Ceni, Cepeda, Cepeda, Cepeda, Cepeda, Cepeda, Chan, Chang, Chaturvedi, Chen, Chiba, Chrivia, Clarke, Colomer, Coulson, Cummings, Cummings, Cummings, Cummings, Cybulska-Klosowicz, Davies, Deckel, Deckel, Deckel, Deng, Desplats, Di, Diaz-Hernandez, DiFiglia, Dubnau, Dumas, Ehrnhoefer, Eichenbaum, Eichenbaum, Estrada-Sanchez, Estrada-Sanchez, Fan, Fan, Fan, Ferrante, Ferrante, Ferrer, Ferreri, Fossale, Friedman, Gafni, Gardian, Gharami, Ghilan, Giampa, Giampa, Gines, Gines, Gines, Gines, Giralt, Giralt, Giralt, Giralt, Giralt, Giralt, Gladding, Gonzales, Gorski, Graveland, Gray, Greferath, Gruart, Gu, Gu, Hahn-Barma, Harrington, Hebb, Heck, Heckman, Herndon, Hickey, Ho, Hodges, Hodgson, Hong, Hult, Ille, Jarabek, Jia, Jia, Jiang, Joshi, Kalkhoven, Kandel, Kandel, Kandel, Kassubek, Kehoe, Kelly, Kennedy, Kessels, Killoran, Kim, Klapstein, Kleiman, Kleppisch, Korzus, Kumar, Kwok, Labbadia, Laforet, Lawrence, Lawrence, Lawrence, Lee, Lee, Lee, Lee, Lemiere, Lerner, Levine, Levine, Li, Li, Li, Li, Li, Lin, Lione, Lonze, Lonze, Lu, Luthi-Carter, Luthi-Carter, Lynch, Lynch, Ma, Ma, MacPhee, Mangiarini, Mansuy, Marco, Marder, Marti, Mayford, Mazarakis, McBride, McCampbell, Meade, Menalled, Menalled, Metzler, Miguez, Miller, Milnerwood, Milnerwood, Milnerwood, Mitsuishi, Montaldi, Montoya, Morton, Morton, Murmu, Murphy, Nguyen, Niccolini, Nithianantharajah, Norris, Nucifora, Numakawa, Ogryzko, Oike, Orth, Padovan-Neto, Paoletti, Papoutsi, Papp, Parker, Parker, Paulsen, Paulsen, Paulsen, Peixoto, Penzes, Penzes, Penzes, Perez-Otano, Perez-Severiano, Pineda, Plotkin, Plotkin, Politis, Poo, Popoli, Popoli, Popugaeva, Poudel, Poudel, Pouladi, Pouladi, Puerta, Puigdellivol, Putney, Puzzo, Raamsdonk, Raamsdonk, Raamsdonk, Raamsdonk, Raamsdonk, Radhakrishnan, Ramaswamy, Ravnskjaer, Raymond, Reiner, Roberts, Rocher, Rosas, Rosas, Rosch, Rosenberg, Rosenfeld, Rossi, Rouaux, Roze, Rue, Runne, Russell, Saavedra, Saavedra, Saavedra, Sadri-Vakili, Sapp, Sapp, Saura, Schaffar, Schilling, Schippling, Schneider, Seo, Sepers, Seredenina, Shepherd, Shirasaki, Silva, Simmons, Siuciak, Skaper, Slow, Smith, Song, Sotrel, Spampanato, Spargo, Spires, Stack, Steffan, Steffan, Stout, Stout, Sugars, Sun, Suopanki, Tang, Tang, Taylor, Thakur, The Huntington's Disease Collaborative Research Group, Thierry, Threlfell, Threlfell, Troy, Trueman, Turmaine, Tyebji, Unschuld, Valor, Vecsey, Verny, Victorson, Vo, Voermans, von Bohlen Und, Vonsattel, Vonsattel, Wang, Wheeler, Wheeler, Wheeler, Wheeler, Wong, Woo, Wood, Wu, Wu, Wu, Xie, Xie, Xifro, Xifro, Xifro, Xu, Yamamoto, Yamashita, Yhnell, Yhnell, Yu, Zagrebelsky, Zakzanis, Zee, Zhang, Zuccato, Zuccato, Zuccato, Zuccato, Zuccato, Zuccato, Zuccato +353 morecore +1 more sourceType 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing
Advanced Science, EarlyView.The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.Lu Huang, Xinran Ye, Chia‐Kang Ho, Ya Gao, Dongsheng Wen, Jiaming Sun, Yuxin Liu, Yangdan Liu, Guoyuan Wang, Yangbai Sun, Jinyan Zhang, Yifan Zhang, Qingfeng Li +12 morewiley +1 more source
