Results 111 to 120 of about 16,016 (265)

Single‐Vesicle Functional Nanophenotyping Reveals Heterogeneous PD‐L1 Accessibility in Triple‐Negative Breast Cancer

Small Methods, EarlyView.
Graphical Abstract. High‐speed atomic force microscopy enables real‐time, label‐free visualization of antibody interactions with individual extracellular vesicles. By quantifying binding frequency and dwell time, this approach reveals functional PD‐L1 accessibility that cannot be inferred from protein abundance alone, uncovering nanoscale heterogeneity
Reon Imakawa, Keesiang Lim, Takeshi Yoshida, Tomoyoshi Yamano, Tsunaki Hongu, Uryo Onishi, Masaharu Hazawa, Toshio Ando, Noriko Gotoh, Rikinari Hanayama, Richard W. Wong   +10 more
wiley   +1 more source

Porous Deep Eutectic Solvents–Unfulfilled Dream or the Next Breakthrough in Scientific Innovation?

Advanced Science
Porous deep eutectic solvents (PDES) are capturing the imagination of scientists, promising a revolutionary leap in material science. These innovative materials, blending the versatility of deep eutectic solvents (DES) with the intricate architectures of
Marcin Wysokowski, Patrycja Makoś‐Chełstowska, Alina Brzęczek‐Szafran, Aleksandra Sikora, Adam Gorczyński, Teofil Jesionowski   +5 more
doaj   +1 more source

Dopamine: The Essential Bridge Mediating Obstructive Sleep Apnea and Hippocampus‐Dependent Learning and Memory Impairments

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley   +1 more source

Correlation Between Anastomotic Leakage and the Anastomotic Position of the Gastric Conduit After Esophagectomy Using ICG Fluorescence Imaging Stratification

World Journal of Surgery, EarlyView.
This study aimed to clarify the correlation between anastomotic leakage and anastomotic position after esophagectomy for esophageal cancer, stratified by gastric conduit blood flow assessed using indocyanine green (ICG) fluorescence imaging. ABSTRACT Background This study aimed to clarify the correlation between anastomotic leakage and anastomotic ...
Yamato Ninomiya, Kazuo Koyanagi, Rie Nakashima, Kohei Tajima, Kohei Kanamori, Mika Ogimi, Yoshiaki Shoji, Akihito Kazuno, Miho Yamamoto, Masaki Mori   +9 more
wiley   +1 more source

Fault‐Tolerant Fuzzy Boundary Control for Nonlinear Distributed Parameter Systems Under Limited Measurements and Markovian Failures

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT This paper proposes a boundary control method for nonlinear distributed parameter systems (DPSs) with limited boundary measurements (BMs), as typically encountered in networked cyber‐physical processes with spatially distributed dynamics such as thermal and biomedical diffusion systems.
Yanlin Li, Kaibo Shi, Yue Yu, Xiangkun Wang, Ming Zhu, Xiao Cai   +5 more
wiley   +1 more source

DualSS: A Dual‐Diffusion Synthetic Sampling Framework for Screening Fatty Liver Severity With Class‐Imbalanced Tongue Images

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Fatty liver disease (FLD) is a prevalent chronic condition that can progress to clinically significant liver injury if left untreated. Given its high prevalence, FLD poses a substantial public health burden. Traditional Chinese medicine suggests that the appearance of tongue reflects hepatic and metabolic status, enabling artificial ...
Tao Chen, Jie Gao, Yong Xu, Weihong Qiu, Kunhong Liu, Yijie Wu, Weimin Ye   +6 more
wiley   +1 more source

Treatment Patterns and Pathways of Systemic Drug Therapy in Patients With Plaque, Erythrodermic, and Generalized Pustular Psoriasis: A Retrospective Cohort Study in Japan

The Journal of Dermatology, EarlyView.
ABSTRACT Systemic psoriasis treatment options have rapidly expanded in Japan, including the approval of tyrosine kinase 2 and interleukin‐36 receptor inhibitors in 2022. However, contemporary real‐world treatment patterns across plaque, erythrodermic, and generalized pustular psoriasis remain incompletely characterized.
Yayoi Tada, Yoshiko Maeda, Miyuki Hasegawa, Motonobu Sakaguchi, Takamasa Hashimoto, Teruko Narusawa, Nobuyoshi Takabayashi, Tomoko Takahashi, Taisuke Kondo, Shingo Kuroda   +9 more
wiley   +1 more source

Systemic Treatment of Psoriasis: Current Evidence on Efficacy and Safety

The Journal of Dermatology, EarlyView.
ABSTRACT Systemic treatments for moderate‐to‐severe plaque psoriasis have been advanced from broad immunosuppressants up to agents more selectively targeting cytokines, cytokine receptors, or intracellular signaling. The current systemic treatments mainly consist of conventional systemic agents, biologics targeting tumor necrosis factor (TNF)‐α ...
Teppei Hagino, Naoko Kanda
wiley   +1 more source

Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals

Integrative Zoology, EarlyView.
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong, Chunxu Wang, Enqing Pei, Liang Zhao, Simin Chai, Ran Tian   +5 more
wiley   +1 more source

The Australian Hydromyine Rodents—Their Interspecific Diversity and Reproductive Biology: A Review

Integrative Zoology, EarlyView.
There are two major groups, the Rattus species and the Hydromyini, in Australia. Clearly, the hydromyine rodents, unlike the Rattus genus, exhibit a diverse array of reproductive biological traits in both males and females, the full evolutionary significance of which has yet to be ascertained.
William G. Breed, Christopher M. Leigh, Eleanor J. Peirce   +2 more
wiley   +1 more source