Results 71 to 80 of about 36,515 (306)
AIChE Journal, EarlyView.ABSTRACT Hybrid modeling combines first‐principles equations with a data‐driven subcomponent. Training for the data‐driven part is sensitive to measurement noise when training targets are constructed using pointwise time derivatives. Beyond differentiation errors, hybrid models involve solving an inverse problem to estimate the data‐driven term, which ...
Hangjun Cho +4 more
wiley +1 more source
Biosensors, 2016 We explore the fabrication, physicochemical characterisation (SEM, Raman, EDX and XPS) and electrochemical application of hand-drawn pencil electrodes (PDEs) upon an ultra-flexible polyester substrate; investigating the number of draws (used for their ...
Elena Bernalte +5 more
doaj +1 more source
Cyclic AMP control measured in two compartments in HEK293 cells: phosphodiesterase K(M) is more important than phosphodiesterase localization. [PDF]
PLoS ONE, 2011 The intracellular second messenger cyclic AMP (cAMP) is degraded by phosphodiesterases (PDE). The knowledge of individual families and subtypes of PDEs is considerable, but how the different PDEs collaborate in the cell to control a cAMP signal is still ...
Karina Matthiesen, Jacob Nielsen
doaj +1 more source
Overview of PDEs and Their Regulation [PDF]
Circulation Research, 2007 Contraction and relaxation of vascular smooth muscle and cardiac myocytes are key physiological events in the cardiovascular system. These events are regulated by second messengers, cAMP and cGMP, in response to extracellular stimulants. The strength of signal transduction is controlled by intracellular cyclic nucleotide concentrations, which are ...
Kenji, Omori, Jun, Kotera
openaire +2 more sources
Advanced Intelligent Discovery, EarlyView.This perspective highlights how knowledge‐guided artificial intelligence can address key challenges in manufacturing inverse design, including high‐dimensional search spaces, limited data, and process constraints. It focused on three complementary pillars—expert‐guided problem definition, physics‐informed machine learning, and large language model ...
Hugon Lee +3 more
wiley +1 more source
Modified plant‐derived exosomes: Precision medicine in cancer treatment
Clinical and Translational DiscoveryPlant‐derived exosomes (PDEs) are extracellular vesicles (EVs) occurring naturally,which have propitious applications in the development of cost‐effective and fruitful cancer therapy with minimum aftereffects and ramifications.
Swastika Maitra +2 more
doaj +1 more source
Toward Intelligent Multimodal Holography for Real‐Time Chemical Imaging of Dynamic Ion Separation
Advanced Intelligent Discovery, EarlyView.Intelligent multimodal holography integrates digital off‐axis holography, spectroscopic imaging, and AI‐driven reconstruction to visualize ion transport and chemical dynamics in real time. In this perspective paper, we outline how this approach enables label‐free, chemically specific monitoring of complex environments and discuss its potential to ...
Giovanna Ricchiuti +3 more
wiley +1 more source
Kompetitive Bildkompression mit linearen PDEs [PDF]
, 2016 In recent years, image compression methods with partial differential equations (PDEs) have become a promising alternative to standard methods like JPEG or JPEG2000.
Hoffmann, Sebastian
core +1 more source
Phosphodiesterase and psychiatric disorders: a two-sample Mendelian randomization study
Journal of Translational Medicine, 2023 Background Phosphodiesterases (PDEs) have been associated with psychiatric disorders in observational studies; however, the causality of associations remains unestablished.
Miaomiao Jiang +7 more
doaj +1 more source
Advanced Intelligent Discovery, EarlyView.AI‐BioMech is a deep learning framework that predicts the mechanical behavior of biological cellular materials directly from 2D images. By replacing traditional finite element analysis with semantic segmentation, it identifies stress and strain distributions with 99% accuracy, offering a high‐speed, scalable alternative for analyzing complex, aperiodic
Haleema Sadia +2 more
wiley +1 more source