Results 61 to 70 of about 112,958 (338)

Pu-18-N-butylimide-NMGA-GNP conjugate is effective against hepatocellular carcinoma

Integrative Medicine Research, 2013
Background: Photodynamic therapy (PDT) is a new modality in the treatment of cancer. This study thus aims to examine whether the PDT is effective against in vivo hepatocellular carcinoma.
Jin-Geun Kwon, In-Sung Song, Min-Soo Kim, Beom Hee Lee, Jung Hwa Kim, Il Yoon, Young Key Shim, Nari Kim, Jin Han, Jae Boum Youm   +9 more
doaj   +1 more source

Predictive biomarkers for 5‐ALA‐PDT can lead to personalized treatments and overcome tumor‐specific resistances

Cancer Reports, 2022
Background Photodynamic therapy (PDT) is a minimally invasive, clinically approved therapy with numerous advantages over other mainstream cancer therapies.
Maria Mastrangelopoulou, Mantas Grigalavicius, Tine H. Raabe, Ellen Skarpen, Petras Juzenas, Qian Peng, Kristian Berg, Theodossis A. Theodossiou   +7 more
doaj   +1 more source

The Effect of 5-Aminolevulinic Acid Photodynamic Therapy in Promoting Pyroptosis of HPV-Infected Cells

Photonics, 2022
5-aminolevulinic acid photodynamic therapy (ALA-PDT) is highly effective in the treatment of condyloma acuminata (CA). Previous research has indicated that ALA-PDT could induce cell death by different mechanisms, including apoptosis and autophagy, but ...
Junxiao Wei, Xiaoming Peng, Sijia Wang, Meinian Xu, Hui Liu, Yixiu Zhong, Xi Chen, Qi Wang, Xiaowen Huang, Kang Zeng   +9 more
doaj   +1 more source

An oxygen self-sufficient NIR-responsive nanosystem for enhanced PDT and chemotherapy against hypoxic tumors

Chemical Science, 2019
An oxygen self-sufficient NIR-responsive nanoplatform enhances the efficiency of synergistic treatments between PDT and chemotherapy in hypoxic tumors.
Guoliang Yang, Jia Tian, Chao Chen, Dawei Jiang, Yudong Xue, Chao-Chao Wang, Yun Gao, Weian Zhang   +7 more
semanticscholar   +1 more source

Modification‐Selective Inhibition of Succinate Dehydrogenase a Enables Tumor‐Restricted Mitochondrial Modulation

Advanced Science, EarlyView.
This work identifies acetylation‐dependent SDHA homeostasis as a determinant of tumor‐specific metabolic vulnerability. Guided by this mechanism, a modification‐selective inhibitor, ZPI‐3, selectively targets non‐acetylated SDHA, achieving tumor‐restricted SDH inhibition and effective bladder cancer control. Differential responses in clinical specimens
Kaikai Xu, Lulu Kong, Kebin Ye, Xinlu Bao, Haowen Liu, Ning Wang, Yongming Deng, Wei Wang, Shaohua Wei, Lin Zhou   +9 more
wiley   +1 more source

Progression-directed therapy in patients with oligoprogressive castration-resistant prostate cancer [PDF]

Investigative and Clinical Urology
Purpose: Oligoprogressive lesions are observed in a subset of patients who progress to castration-resistant prostate cancer (CRPC), while other lesions remain controlled by systemic therapy. This study evaluates the impact of progression-directed therapy
Jun Nyung Lee, Mi Young Kim, Jae Hoon Kang , Jun-Koo Kang, Jae-Wook Chung, Yun-Sok Ha, Seock Hwan Choi, Bum Soo Kim, Hyun Tae Kim, Tae-Hwan Kim, Eun Sang Yoo, See Hyung Kim, Tae Gyun Kwon   +12 more
doaj   +1 more source

Trial watch: an update of clinical advances in photodynamic therapy and its immunoadjuvant properties for cancer treatment

OncoImmunology, 2023
Photodynamic therapy (PDT) is a medical treatment used to target solid tumors, where the administration of a photosensitizing agent and light generate reactive oxygen species (ROS), thus resulting in strong oxidative stress that selectively damages the ...
Mafalda Penetra, Luís G. Arnaut, Lígia C. Gomes-da-Silva   +2 more
doaj   +1 more source

Hydraulic Pressure‐Programmed Molecular Transport in Tough Hydrogels

Advanced Science, EarlyView.
Hydraulic pressure is introduced as a programmable parameter for regulating molecular transport in tough hydrogel membranes. Reversing the pressure direction accelerates or slows transport, tuning characteristic transport times over a 65‐fold range while achieving molecular separation and controlled delivery.
Yijie Cheng, Shahd Alnasser, Akhiri Zannat, Zhenda He, Jiayi Zeng, Lenan Zhang, Sungmin Hong, Xinyue Liu   +7 more
wiley   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Different effects of single and fractionated light delivery regimes in photodynamic therapy with hypericin on HT-29 cells in vitro [PDF]

, 2009
Photodynamic therapy (PDT) is an alternative cancer cure which involves the selective uptake and retention of a photosensitizer in a cancer tissue, followed by irradiation with light of a specific wavelength to kill tumour cells via the production of ...
Grada Kulikova, Lucia
core   +1 more source