Results 71 to 80 of about 112,958 (338)

Organic Nanozyme‐Embedded Biotherapeutic Thermosensitive Hydrogel for Extracellular GSH Depletion and Postoperative Tumor Suppression

open access: yesAdvanced Science, EarlyView.
A temperature‐sensitive hydrogel loaded with cyanine nanozymes and Escherichia coli is locally injected into postoperative tumor resection beds. Upon light irradiation, synergistic PTT and PDT work with cascaded reactive oxygen species to deplete extracellular GSH, eliminate residual tumor cells, and induce robust antitumor immune responses for ...
Cong Jiang   +10 more
wiley   +1 more source

Melayani sepenuh diri, in memoriam Pdt. Lian Padele (1961 - 2020)

open access: yes, 2021
Buku ini berisi tulisan-tulisan untuk mengenang dan menghargai Pdt. Dr.
I Gede Supradnyana   +4 more
core  

Self-assembled IR780-loaded transferrin nanoparticles as an imaging, targeting and PDT/PTT agent for cancer therapy

open access: yesScientific Reports, 2016
Combination of photothermal and photodynamic therapy (PTT/PDT) offer unique advantages over PDT alone. However, to achieve synergetic PDT/PTT effect, one generally needs two lasers with different wavelengths.
Kai-Kai Wang   +6 more
semanticscholar   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

open access: yesAngewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen   +3 more
wiley   +2 more sources

The effectiveness and safety of X-PDT for cutaneous squamous cell carcinoma and melanoma.

open access: yesNanomedicine, 2019
Aim: To clarify the effectiveness and safety of x-ray-activated photodynamic therapy (X-PDT) for cutaneous squamous cell carcinoma (SCC) and melanoma. Materials & methods: Copper-cysteamine nanoparticles were used as a photosensitizer of X-PDT.
Lei Shi   +9 more
semanticscholar   +1 more source

Carrier‐Free Stimulus‐Responsive Theranostic Nanoprodrug Enabling GSH‐Consumption‐Promoted Chemo‐Photodynamic Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Leveraging the critical role of glutathione (GSH) in mediating drug resistance and scavenging reactive oxygen species (ROS) in cancer cells, a carrier‐free GSH‐consuming theranostic nanoprodrug, consisting of a BODIPY photosensitizer and the chemotherapeutic drug paclitaxel linked through a GSH‐consuming drug linker, is developed to deeply explore the ...
Hansheng Huang, Binglin Sui
wiley   +1 more source

Sequential Design of Activatable Photosensitizers for Ablation of Glioma Cells in Brain Cancer Tissues

open access: yesAngewandte Chemie, EarlyView.
Gal‐SeNBD‐oleamide is an activatable photosensitizer (PS) with efficient uptake and selective, β‐galactosidase‐triggered activation in cancer cells, enabling efficient photodynamic ablation of glioma cells directly in brain tissue slices from mouse preclinical models and human glioblastoma patients.
Utsa Karmakar   +18 more
wiley   +2 more sources

Lipophilicity of Bacteriochlorin-Based Photosensitizers as a Determinant for PDT Optimization through the Modulation of the Inflammatory Mediators

open access: yesJournal of Clinical Medicine, 2019
Photodynamic therapy (PDT) augments the host antitumor immune response, but the role of the PDT effect on the tumor microenvironment in dependence on the type of photosensitizer and/or therapeutic protocols has not been clearly elucidated.
Barbara Pucelik   +2 more
semanticscholar   +1 more source

Dosimetric concepts for PDT

open access: yesPhotodiagnosis and Photodynamic Therapy, 2008
Photodynamic therapy (PDT) is a well-known treatment regimen that involves the interaction of light with a photosensitizing agent and oxygen. The treatment proceeds through the light activation of a tissue localized photosensitizer achieving an excited state.
openaire   +2 more sources

Unlocking Long‐Lived Charge‐Separated State in Pentamethine Cyanine Based on Anionic Hofmeister Effect for Photodynamic Immunotherapy

open access: yesAdvanced Science, EarlyView.
Based on the anionic Hofmeister effect, a universal strategy of incorporation of stereo‐π anion BPh4− into a series of Cy5 skeletons to unlock long‐lived charge‐separated states was reported, wherein the weak electronic coupling and low charge recombination driving force hinder the charge recombination process, elevating the oxygen‐independent ROS ...
Xuan Zhao   +9 more
wiley   +1 more source

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