Results 141 to 150 of about 42,500 (243)

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Analysis of Peripheral T Cell Profiling and Plasma Proteomics in Advanced NSCLC Patients Treated With Atezolizumab

Cancer Science, EarlyView.
This study found immune markers that may predict how well patients with advanced lung cancer respond to atezolizumab. Higher levels of certain T cells were linked to better survival. Specific patterns suggested a worse prognosis for some patients. ABSTRACT We investigated immunologic biomarkers that predict outcomes of patients with previously treated ...
Atsuto Mouri, Hiroshi Kagamu, Koji Tamada, Makoto Nishio, Hiroaki Akamatsu, Yasushi Goto, Hidetoshi Hayashi, Satoru Miura, Akihiko Gemma, Ichiro Yoshino, Toshihiro Misumi, Ryota Saito, Noriko Yanagitani, Fujita Masaki, Hiroshi Nokihara, Kazumi Nishino, Masahiro Seike, Tetsunari Hase, Osamu Hataji, Hiroaki Takeoka, Yosuke Kawashima, Hirotaka Kuroki, Masamichi Sugimoto, Hiroshi Kuriki, Tetsuya Mitsudomi   +24 more
wiley   +1 more source

Clinical Applications of Phosphoproteomics: Illuminating Cancer Signaling and Enabling Rational Therapeutic Strategies

Cancer Science, EarlyView.
Mass spectrometry‐based phosphoproteomics for mechanistic dissection of cancer signaling pathways and uncovering therapeutic vulnerabilities. ABSTRACT Protein phosphorylation is a central post‐translational modification regulating cellular signaling, frequently dysregulated in cancer.
Hirokazu Shoji, Narikazu Boku, Jun Adachi   +2 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

ASCIA Guideline: Infant Feeding for Food Allergy Prevention

Clinical &Experimental Allergy, EarlyView.
The 2025 Australasian Society of Clinical Immunology and Allergy (ASCIA) Guideline: Infant Feeding for Food Allergy Prevention supersedes the 2016 ASCIA guideline. Key changes include specific recommendations about the timing of egg and peanut introduction to the infant's diet, alongside a recommendation regarding perioral rashes to support primary ...
S. L. Vale, M. J. Netting, C. J. Hornung, J. Smith, I. Roche, V. McWilliam, K. Hollinshead, C. South, A. Young, K. Rueter, K. P. Perrett, D. J. Palmer, P. Joshi, D. E. Campbell, J. J. Koplin, L. S. Ford   +15 more
wiley   +1 more source

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Occupational Contact Urticaria, Protein Contact Dermatitis and Concomitant Airway Diseases in the Finnish Register of Occupational Diseases in 2005–2020: Main Causes and Occupations at Risk

Contact Dermatitis, EarlyView.
This Finnish registry study shows that concomitant occupational asthma and rhinitis are common in patients with occupational contact urticaria or protein contact dermatitis, often sharing the same exposure. When evaluating occupational immediate allergy, both skin and airway symptoms should be considered.
Ville Ojanen, Liisa Airaksinen, Hille Suojalehto, Kirsi Koskela, Maria Pesonen   +4 more
wiley   +1 more source

Spectral Characterization of the Life Stages and Physiological Responses of Diatraea saccharalis Fabricius (Lepidoptera: Crambidae) Larvae Parasitized by Cotesia flavipes Cameron (Hymenoptera: Braconidae)

Entomologia Experimentalis et Applicata, EarlyView.
Hyperspectral proximal sensing was used to characterize the life stages and physiological responses of Diatraea saccharalis and to detect parasitism by Cotesia flavipes. Distinct spectral signatures differentiated eggs, larval instars, pupae, and adults, as well as live, dead, and parasitized larvae.
Souradji I. Bachirou, David L. Rosalen, Sergio A. De Bortoli, Pedro G. Peixoto   +3 more
wiley   +1 more source

Do aphid endosymbiotic bacteria influence parasitoid searching behaviour through changes in aphid honeydew production?

Ecological Entomology, EarlyView.
Hamiltonella defensa infection increases honeydew production in certain aphid genotypes, potentially modifying aphid feeding behaviour. Parasitoid wasps, Aphidius ervi, are more attracted to honeydew from H. defensa‐infected aphids; though larger honeydew amounts may slightly deter searching.
Desiré Macheda, Alexandre Foito, Katharine F. Preedy, Colin J. Alexander, Ankush Prashar, Alison J. Karley   +5 more
wiley   +1 more source

Temporohyoid osteoarthropathy: Recurrence of clinical signs following standing partial ceratohyoidectomy in a Swiss Warmblood mare

Equine Veterinary Education, EarlyView.
Summary A 17‐year‐old Swiss Warmblood mare presented with signs of left‐sided facial nerve paralysis and was diagnosed with left‐sided temporohyoid osteoarthropathy (THO). A partial ceratohyoidectomy was performed in the standing, sedated mare to treat this condition.
J. Kuhlmann, E. Van der Vekens, C. Koch, M. D. Klopfenstein Bregger, M. de Preux, H. P. Brünisholz   +5 more
wiley   +1 more source