Results 241 to 250 of about 176,875 (311)

Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model

Advanced Science, EarlyView.
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen, Yang Zhao, Boqiang Hu, Wuke Wang, Minfang Song, Annabeth Xinyu Zhao, Xiangyang Li, Gefei Wang, Yanfen Wang, Weiyan Zheng, Xinpeng Zhang, Xia Lin, Yanbin Yin, Xingxu Huang, Jinfang Zheng, Tingbo Liang   +15 more
wiley   +1 more source

Delayed completion of pneumococcal conjugate vaccination among children 4-48 months in rural Uganda: a socio-demographic inquiry. [PDF]

BMC Pediatr
Malemo H, Tamale A, Kakwangire P, Igwe MC, Mwine DR, Asiimwe I, Mbina SA, Abalinda MG.   +7 more
europepmc   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Antibiotic Susceptibility Profiles and Determinants of Septic Abortion Among Women Admitted for Abortion Care in Ugandan Satellite Teaching Hospitals: A Two-Center Cross-Sectional Study. [PDF]

Health Sci Rep
Gaboose GB, Ishimwe MPS, Mulumba R, Kazigo AK, Nteziyaremye T, Hakizimana T.   +5 more
europepmc   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Pre-Exposure Prophylaxis Awareness and Demand Creation: Overlooked Populations and Opportunities to Move Forward. [PDF]

J Acquir Immune Defic Syndr
McCoy K, Mantell JE, Deiss R, Liu A, Bauman LJ, Bonner CP, Vinson J, Buchbinder S.   +7 more
europepmc   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Reseña de "Studies in Peasant Life: Community and Society", de Clifford Geertz

Revista Colombiana de Antropología, 2016
Alen Felipe Castaño
doaj  

Divine thus good, devilish thus bad? Folk linguistic perceptions about plants and their characteristics in Polish folklore. [PDF]

J Ethnobiol Ethnomed
Kielak O.
europepmc   +1 more source

Review Of The Origins Of English Individualism: The Family, Property And Social Transition By A. Macfarlane [PDF]

, 1980
Pryor, Frederic L.
core   +1 more source