Results 121 to 130 of about 21,315 (292)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Optimised ‘hybrid’ scenario H-mode plasmas for W radiation control in JET with the Be/W wall

Nuclear Fusion
Screening of high- Z (W) impurities from the confined plasma by the temperature gradient at the plasma periphery of fusion-grade H-mode plasmas was demonstrated for the first time in JET with the Be/W wall (Field et al 2023 Nucl.
A.R. Field, C. Angioni, I.S. Carvalho, P. Carvalho, C.D. Challis, A. Chomiczewska, I.H. Coffey, D. Fajardo, L. Frasinetti, J.M. Fontdecaba, C. Giroud, J. Hobirk, A. Kappatou, D. Keeling, D.B. King, D. Kos, B. Labit, E. Lerche, E. Litherland-Smith, S. Menmuir, C. Olde, H. Sun, N. Vianello, S. Wiesen, JET Contributors, the EUROfusion Tokamak Exploitation Team   +25 more
doaj   +1 more source

Plinths and Pedestals

The Mathematical Intelligencer
In this paper we explain what are the plinths and the pedestals of the skyscrapers (=plane partitions), and how one can use them in order to count the skyscrapers.
Ogievetsky, Oleg, Shlosman, Senya
openaire   +3 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Qualitative effects of resistivity in JET-ILW Europed pedestal predictions

Nuclear Fusion
The effect of resistive MHD in the pedestal predictions for JET-ILW has been investigated, using the Europed workflow (Saarelma et al 2018 Plasma Phys. Control. Fusion 60 014042) with the resistive MHD stability code CASTOR (Kerner et al 1998 J.
A. Lafay-Labrosse, H. Nyström, L. Frassinetti, S. Saarelma, JET Contributors, The EUROfusion Tokamak Exploitation Team   +5 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Quantifying resolution limits in pedestal profile measurements with Gaussian process regression

Nuclear Fusion
Edge transport barriers in magnetically confined fusion plasmas, commonly known as pedestals, play a crucial role in achieving high confinement plasmas.
Norman M. Cao, David R. Hatch, Craig Michoski, Todd A. Oliver, David Eldon, Andrew Oakleigh Nelson, Matthew Waller   +6 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Understanding the formation of a low-pressure pedestal in the presence of a strong internal transport barrier in DIII-D high βp plasmas

Nuclear Fusion
As a promising scenario for fusion reactors, the high poloidal-beta ( ${\beta _{\text{P}}}$ ) scenario is characterized by a strong large radius internal transport barrier (ITB), which significantly enhances the overall confinement quality and the ...
X.R. Zhang, X. Jian, Y.R. Zhu, Y.P. Zou, Z.Y. Li, Y.J. Zhou, L.Z. Liu, S. Zheng, Z.X. Wang, W. Chen, S.Y. Ding, A.M. Garofalo, V.S. Chan, G.Q. Li   +13 more
doaj   +1 more source