Results 101 to 110 of about 25,837 (278)

Investigation of pedestal parameters and divertor heat fluxes in small ELM regimes in DIII-D

Nuclear Fusion
Divertor heat flux and its correlation with pedestal parameters within various small edge localized mode (ELM) regimes, including high beta poloidal, type-II and ELMs with negative triangularity H-modes were investigated in DIII-D.
P.J. Traverso, M. Knolker, M. Austin, C. Lasnier, A.W. Leonard, T. Osborne, H. Wang   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Pedestal main ion particle transport inference through gas puff modulation with experimental source measurements

Nuclear Fusion
Transport in the DIII-D high confinement mode (H-mode) pedestal is investigated through a periodic edge gas puff modulation (GPM) which perturbs the deuterium density and source profiles.
A.M. Rosenthal, J.W. Hughes, F.M. Laggner, T. Odstrčil, A. Bortolon, T.M. Wilks, S. Mordijck, M.A. Miller, F. Sciortino   +8 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Optimised ‘hybrid’ scenario H-mode plasmas for W radiation control in JET with the Be/W wall

Nuclear Fusion
Screening of high- Z (W) impurities from the confined plasma by the temperature gradient at the plasma periphery of fusion-grade H-mode plasmas was demonstrated for the first time in JET with the Be/W wall (Field et al 2023 Nucl.
A.R. Field, C. Angioni, I.S. Carvalho, P. Carvalho, C.D. Challis, A. Chomiczewska, I.H. Coffey, D. Fajardo, L. Frasinetti, J.M. Fontdecaba, C. Giroud, J. Hobirk, A. Kappatou, D. Keeling, D.B. King, D. Kos, B. Labit, E. Lerche, E. Litherland-Smith, S. Menmuir, C. Olde, H. Sun, N. Vianello, S. Wiesen, JET Contributors, the EUROfusion Tokamak Exploitation Team   +25 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Pedestal

, 2018
Pedestal, 2014, ação com pessoa e bloco de gesso.
Soledar, Jorge
core  

[Stone pedestal on street]

, 1969
Photograph of a stone pedestal with a chain coming off the right side.

core   +1 more source

Qualitative effects of resistivity in JET-ILW Europed pedestal predictions

Nuclear Fusion
The effect of resistive MHD in the pedestal predictions for JET-ILW has been investigated, using the Europed workflow (Saarelma et al 2018 Plasma Phys. Control. Fusion 60 014042) with the resistive MHD stability code CASTOR (Kerner et al 1998 J.
A. Lafay-Labrosse, H. Nyström, L. Frassinetti, S. Saarelma, JET Contributors, The EUROfusion Tokamak Exploitation Team   +5 more
doaj   +1 more source