Results 91 to 100 of about 25,837 (278)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Progress in pedestal and edge physics: Chapter 3 of the special issue: on the path to tokamak burning plasma operation

Nuclear Fusion
This paper describes the extensive progress that has been made in the understanding of tokamak pedestal physics since the 2007 publication of ‘Progress in the ITER Physics Basis’ (Ikeda 2007 Nucl. Fusion 47 E01–S500).
M.E. Fenstermacher (Chair, Pedestal and Edge Physics), L.R. Baylor, E. de la Luna, M.G. Dunne, G.T.A. Huijsmans, A. Kirk, F.M. Laggner, T.H. Osborne, C. Paz-Soldan, S. Saarelma, P.B. Snyder, E. Viezzer, M. Becoulet, K.H. Burrell, A. Cathey, X. Chen, M. Hoelzl, J.W. Hughes, R. Maingi, A.O. Nelson, H. Urano, E. Wolfrum, X.Q. Xu, A. Diallo, L. Frassinetti, S. Futatani, L. Gil, R. Groebner, T. Happel, S.H. Kim, J. King, B. Labit, P.T. Lang, Y.Q. Liu, Z.X. Liu, R. Lunsford, G.Y. Park, U. Sheikh, W. Suttrop, B. Vanovac, R.S. Wilcox, A. Wingen, T. Zhang   +42 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Impact of shape and global β on ASDEX Upgrade pedestal structure

Nuclear Fusion
The stability and confinement of the pedestal, the outermost region of the confined plasma in a tokamak, are crucial for its efficient operation and performance.
L. Radovanovic, E. Wolfrum, M.G. Dunne, G.F. Harrer, F. Aumayr, the ASDEX Upgrade Team   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

EDA H-mode in ASDEX Upgrade: scans of heating power, fueling, and plasma current

Nuclear Fusion
Electron cyclotron resonance heating (ECRH) staircase discharges in strongly shaped plasmas were performed at the full-tungsten ASDEX Upgrade tokamak to investigate the enhanced D _α (EDA) H-mode, a high-confinement regime without edge localized modes ...
L. Gil, T. Pütterich, C. Silva, D. Hachmeister, G.D. Conway, P. David, M. Faitsch, R. Fischer, T. Happel, A. Kallenbach, J. Santos, A. Silva, J. Stober, U. Stroth, E. Viezzer, E. Wolfrum, the ASDEX Upgrade Team, the EUROfusion Tokamak Exploitation Team   +17 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The magnetic coherent mode with shifted Alfvén gap frequency destabilized by the thermal trapped electron resonance in the pedestal of high-confinement tokamak plasmas

Nuclear Fusion
The magnetic coherent modes (MCM) with toroidal mode number n about 1 (Chen R. et al 2018 Nucl. Fusion 58 112004) frequently appear in the edge pedestal of high-confinement tokamak plasmas on EAST in the absence of energetic particles.
Xingquan Wu (伍兴权), Guosheng Xu (徐国盛), Ran Chen (陈冉), Baonian Wan (万宝年)   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source