Results 81 to 90 of about 21,315 (292)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Pedestal structure, stability and scalings in JET-ILW: the EUROfusion JET-ILW pedestal database

, 2020
The EUROfusion JET-ILW pedestal database is described, with emphasis on three main issues. First, the technical aspects are introduced, including a description of the data selection, the datasets, the diagnostics used, the experimental and theoretical ...
Frassinetti, Lorenzo, Imbeaux, Frederic, Hillesheim, Jon, Boehm, Petr, Verdoolaege, Geert, Bilkova, Petra, Fridström, Richard, Dunne, Mike G, de la Luna, Elena, Owsiak, Michal, Maggi, Costanza F, Scannell, Rory, Labit, Benoit, Groth, Mathias, Saarelma, Samuli, Giovannozzi, Edmondo   +15 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Role of turbulent separatrix tangle in the improvement of the integrated pedestal and heat exhaust issue for stationary-operation tokamak fusion reactors

Nuclear Fusion
The magnetic separatrix surface is designed to provide the final and critical confinement to the hot stationary-operation core plasma in modern tokamak reactors in the absence of an external magnetic perturbation (MP) or transient magneto-hydrodynamic ...
C.S. Chang, S. Ku, R. Hager, J. Choi, D. Pugmire, S. Klasky, A. Loarte, R.A Pitts   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Non-ideal MHD analysis of pedestal scans of AUG and JET

Nuclear Fusion
The extended MHD code CASTOR3D is used to perform the MHD stability analysis of predictive pedestal scans of standard ASDEX Upgrade and JET-ILW scenarios.
F. Stefanelli, M.G. Dunne, J. Puchmayr, H. Zohm   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Effect of neon seeding on the pedestal structure and stability in the JET-ILW deuterium JET-ITER baseline scenario using both ideal and resistive MHD

Nuclear Fusion
In this work, the effect of neon seeding in the JET-ILW JET-ITER baseline scenario on pedestal structure, global stability and local stability is studied.
H. Nyström, C. Giroud, L. Frassinetti, S. Menmuir, E. Litherland-Smith, J.M. Fontdecaba, D. Kos, Z. Huang, A. Boboc, J. MacDonald, G. Szepesi, JET contributors, EUROfusion Tokamak Exploitation Team   +12 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source