Results 111 to 120 of about 25,837 (278)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Quantifying resolution limits in pedestal profile measurements with Gaussian process regression

Nuclear Fusion
Edge transport barriers in magnetically confined fusion plasmas, commonly known as pedestals, play a crucial role in achieving high confinement plasmas.
Norman M. Cao, David R. Hatch, Craig Michoski, Todd A. Oliver, David Eldon, Andrew Oakleigh Nelson, Matthew Waller   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Modeling temperature profiles in the pedestal of NSTX with reduced models

Nuclear Fusion
This paper describes new modeling capabilities for predicting H-mode pedestal profiles in spherical tokamaks. Temperature profiles for NSTX discharges 132543 (narrow pedestal) and 132588 (wide pedestal, lithiated) are modeled by coupling the astra ...
P.-Y. Li, D.R. Hatch, L.A. Leppin, J. Schmidt, J.F. Parisi, M. Lampert, M. Kotschenreuther, S.M. Mahajan   +7 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Mahogany Sheraton Pedestal Table

, 2010
Support furnitureMahogany pedestal table, oval top, on turned pedestal with ball; base with four downswept legs. Unmarked.mahogany2 1/2"h x 3"w x 2"
Pearson, Eric, miniature maker
core  

Understanding the formation of a low-pressure pedestal in the presence of a strong internal transport barrier in DIII-D high βp plasmas

Nuclear Fusion
As a promising scenario for fusion reactors, the high poloidal-beta ( ${\beta _{\text{P}}}$ ) scenario is characterized by a strong large radius internal transport barrier (ITB), which significantly enhances the overall confinement quality and the ...
X.R. Zhang, X. Jian, Y.R. Zhu, Y.P. Zou, Z.Y. Li, Y.J. Zhou, L.Z. Liu, S. Zheng, Z.X. Wang, W. Chen, S.Y. Ding, A.M. Garofalo, V.S. Chan, G.Q. Li   +13 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Locomotive-Pedestal

, 1911
Patent for a locomotive pedestal.
McCormick, George
core  

Pedestal Stereoscope [PDF]

, 2013
Comprises pedestal casing with internal conveyor mechanism, adjustable eyepieces and light-admitting ...

core