Results 141 to 150 of about 5,885 (271)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Structure, Stability and ELM Dynamics of the H-Mode Pedestal in DIII-D

, 2004
Experiments are described that have increased understanding of the transport and stability physics that set the H-mode edge pedestal width and height, determine the onset of Type-I edge localized modes (ELMs), and produce the nonlinear dynamics of the ...
Colchin, R. J., Osborne, T. H., Kempenaars, M. H., Loarte, A., Zeng, L., Snyder, P. B., Thomas, D. M., Boedo, J. A., Groebner, R. J., Leonard, A. W., Casper, T. A., Groth, M., Fenstermacher, M. E., Saibene, G., VanZeeland, M. A., Xu, X. Q.   +15 more
core  

Spherical tokamak physics research in preparation for the operation of NSTX-U

Nuclear Fusion
The National Spherical Torus Experiment Upgrade (NSTX-U) is preparing to resume operation, representing a crucial step toward realizing compact, cost-effective fusion pilot plants.
S. Munaretto, P.O. Adebayo-Ige, H. Anand, G. Avdeeva, S.G. Baek, K. Barada, E. Belli, E.V. Belova, J.W. Berkery, T.N. Bernard, N. Bertelli, P. Bonofiglo, P.T. Bonoli, M.D. Boyer, J. Candy, C.S. Chang, H. Chung, C. Clauser, M. Comanescu, D. Corona, N.A. Crocker, R. De Levante Rodriguez, E.W. DeShazer, A. Diallo, J. Dominski, V.N. Duarte, F. Ebrahimi, E.D. Emdee, S. Ethier, N.M. Ferraro, E.L. Foley, E.D. Fredrickson, M.E. Galante, K.F. Gan, S. Gerhardt, R.J. Goldston, M. Gorelenkova, W. Guttenfelder, R. Hager, F.D. Halpern, J. Halpern, D. Hatch, F. Hoffmann, M.S. Islam, S.C. Jardin, S.M. Kaye, A. Khodak, J.E. Kinsey, A. Kleiner, E. Kolemen, S. Ku, M. Lampert, B. Leard, B.P. LeBlanc, J.B. Lestz, F.M. Levinton, P.-Y. Li, N.C. Logan, N.A. Lopez, R. Lunsford, T. Macwan, R. Maingi, J. McClenaghan, A.G. McLean, J.E. Menard, Y.-S. Na, A.O. Nelson, M. Ono, A. Pajares, A. Pankin, J. Parisi, F.I. Parra, M.S. Parsons, B.S. Patel, M. Podestá, F.M. Poli, M. Porcelli, T. Rafiq, R. Raman, J.D. Riquezes, S.A. Sabbagh, A. Sanchez-Villar, E. Schuster, S. Shiraiwa, T. Singh, S.P. Smith, D. Smith, V.A. Soukhanovskii, G.M. Staebler, B. Stratton, K.E. Thome, M. Tobin, I.U. Uzun-Kaymak, B. Van Compernolle, W.X. Wang, W. Wehner, A.S. Welander, B.D. Wirth, J. Yang, V. Zamkovska, X. Zhang   +100 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Pedestal structure and stability in JET-ILW and comparison with JET-C [Elektronisk resurs]

, 2020
Controlled thermonuclear fusion offers a promising concept for safe and sustainable production of electrical energy. However, there are still many issues to be investigated on the way to a commercial fusion reactor.
Mailloux, Joelle,, Frassinetti, Lorenzo,, Brunsell, Per,, Stefanikova, Estera,   +3 more
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Pedestal structure and stability in JET-ILW and comparison with JET-C

, 2020
Controlled thermonuclear fusion offers a promising concept for safe and sustainable production of electrical energy. However, there are still many issues to be investigated on the way to a commercial fusion reactor.
Stefanikova, Estera
core  

Studies of the pedestal structure and inter-ELM pedestal evolution in JET with the ITER-like wall

Studies of the pedestal structure and inter-ELM pedestal evolution in JET with the ITER-like wall
The pedestal structure of type I ELMy H-modes has been analysed for JET with the ITER-like Wall (JET-ILW). The electron pressure pedestal width is independent of ρ* and increases proportionally to √βpol,PED. Additional broadening of the width is observed, at constant βpol, PED, with increasing ν* and/or neutral gas injection and the contribution of ...
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