Results 131 to 140 of about 5,885 (271)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Exploring pedestal structure and stability : insights from shaping in βpol variants in ASDEX upgrade [PDF]

Zukünftige Fusionsreaktoren des Tokamak-Typs werden höchstwahrscheinlich im Hoch- Einschlussmodus (H-Mode) betrieben, einem Regime, das den Einschluss durch die Bildung eines steilen Druckgradienten am Plasmarand verbessert.
Radovanovic, Lidija
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The role of isotope mass on neutral fueling and density pedestal structure in the DIII-D tokamak

Nuclear Fusion
Experimental measurements on DIII-D of hydrogen neutral penetration lengths ( $\lambda_{n_0}$ ) on the high field side (HFS) are longer by a factor of $\sqrt{2}$ than for deuterium consistent with the thermal velocity ratio for neutrals at the same ...
R.A. Chaban, S. Mordijck, A.M. Rosenthal, A. Bortolon, J.W. Hughes, M. Knolker, F.M. Laggner, T.H. Osborne, L. Schmitz, K.E. Thome, T.M. Wilks   +10 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Enhanced pedestal pressure and parameter-linkages determining edge pedestal structure in JT-60U Type I and Type II ELMy H-mode

, 2003
Based on the expanded H-mode operational regimes in JT-60U utilizing the improved capability of high triangularity (δ) operation, the multiple pellet injection and high power heating including the negative ion based NB (NNB), we have clarified the ...
Hatae, T., Takizuka, T., Miura, Y., Kamada, Y., Takenaga, H., Urano, H.   +5 more
core   +1 more source

Effect of toroidal Alfvén Eigenmode nonlinearity on edge localized mode in HL-2A NBI heated H-mode plasmas

Nuclear Fusion
The present paper reports the observation of shear Alfvénic wave fluctuations prior to the edge localized mode (ELM) crash in HL-2A NBI H-mode plasmas.
X.L. Zhu, W. Chen, J. Bao, R. Ke, P.W. Shi, L.M. Yu, Z.B. Shi, Z.Y. Qiu, M. Jiang, H.L. Wei, Y.G. Li, X.X. He, Z.C. Yang, Y.P. Zhang, D.L. Yu, H.T. Chen, R.R. Ma, Z.X. Wang, J.Q. Li, W.L. Zhong   +19 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source