Results 121 to 130 of about 69,287 (288)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Apparatus for sequentially transporting containers [PDF]

open access: yes, 1982
Apparatus for transferring and manipulating a plurality of containers in a sequence is disclosed including a mechanical manipulator arm having a gripping device which automatically picks up a container at a fixed pickup position P and transfers it to a ...
Hudgins, J. L.
core   +1 more source

Model of the W3(OH) environment based on data for both maser and 'quasi-thermal' methanol lines

open access: yes, 2004
In studies of the environment of massive young stellar objects, recent progress in both observations and theory allows a unified treatment of data for maser and 'quasi-thermal' lines.
A.M. Sobolev   +17 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Two-dimensionally Steep Structure of the Electric Field in Tokamak H-mode [PDF]

open access: yes, 2006
The rapid formation of a density pedestal on an L/H transition has been raising a question why the rapid density evolution is induced. Formation of a poloidal shock structure is predicted in H-mode transport barriers, and consideration of the two ...
K. Itoh, N. Kasuya
core  

Qualification Tests of 474 Photomultiplier Tubes for the Inner Detector of the Double Chooz Experiment

open access: yes, 2011
The hemispherical 10" photomultiplier tube (PMT) R7081 from Hamamatsu Photonics K.K. (HPK) is used in various experiments in particle and astroparticle physics.
Bauer, C.   +11 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Identification of a window for quiescent H-mode operation in MHD stability diagram of DIII-D plasmas

open access: yesNuclear Fusion
A window for quiescent H-mode (QH-mode) operation in DIII-D plasmas in the diagram of pedestal magnetohydrodynamic (MHD) stability was identified through linear MHD stability analysis, accounting for the effects of plasma rotation and ion diamagnetic ...
N. Aiba   +3 more
doaj   +1 more source

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