Results 111 to 120 of about 5,885 (271)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The provenance of the norber erratics, and the formation of post-devensian-deglaciation pedestal rocks with carboniferous limestone pedestals in England, Ireland and Wales

This study investigates a Devensian glacial conundrum, the provenance of the Norber erratics in North Yorkshire, and the origins of a post-Devensian-deglaciation landform, pedestal rocks with Carboniferous limestone pedestals in England, Ireland and ...
Parry, Brian
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Tokamak edge-SOL turbulence in H-mode conditions simulated with a global, electromagnetic, transcollisional drift-fluid model

Nuclear Fusion
The design of commercially feasible magnetic confinement fusion reactors strongly relies on the reduced turbulent transport in the plasma edge during operation in the high confinement mode (H-mode).
Wladimir Zholobenko, Kaiyu Zhang, Andreas Stegmeir, Jan Pfennig, Konrad Eder, Christoph Pitzal, Philipp Ulbl, Michael Griener, Lidija Radovanovic, Ulrike Plank, the ASDEX Upgrade Team   +10 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Facilitated core-edge integration through divertor nitrogen seeding in the HL-2A tokamak

Nuclear Fusion
A divertor detachment with sustainable high-performance plasmas has been achieved through divertor nitrogen seeding in the HL-2A tokamak. The closed divertor structure facilitates achieving high divertor neutral pressure due to its efficient particle ...
N. Wu, J. Cheng, K.Y. Yi, R. Wang, M.K. Han, Z.H. Huang, W.C. Wang, Y. He, L.W. Yan, H.L. Du, J.M. Gao, H.C. Ma, X.X. He, Z.C. Yang, J. Wen, K. Zhang, T. Wu, W.P. Guo, X. Yu, L. Liu, Y.G. Li, L. Nie, Z.B. Shi, D.Z. Wang, W.L. Zhong   +24 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Microturbulence in DIII-D tokamak pedestal. I. Electrostatic instabilities

, 2014
Gyrokinetic simulations of electrostatic driftwave instabilities in a tokamak edge have been carried out to study the turbulent transport in the pedestal of an H-mode plasma.
Lin, Z., Holod, I., Xiao, Y., I. Holod, Z. Lin, Y. Xiao, Fulton, D. P., D. P. Fulton   +7 more
core   +1 more source