Results 111 to 120 of about 6,875,269 (237)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The core–edge integrated neon-seeded scenario in deuterium–tritium at JET

Nuclear Fusion
This paper reports the first experiment carried out in deuterium–tritium addressing the integration of a radiative divertor for heat-load control with good confinement. Neon seeding was carried out for the first time in a D–T plasma as part of the second
C. Giroud, I.S. Carvalho, S. Brezinsek, A. Huber, D. Keeling, J. Mailloux, R.A. Pitts, E. Lerche, R. Henriques, J. Hillesheim, K. Lawson, M. Marin, E. Pawelec, M. Sos, H.J. Sun, M. Tomes, S. Aleiferis, A. Bleasdale, M. Brix, A. Boboc, J. Bernardo, P. Carvalho, I. Coffey, S. Henderson, D.B. King, F. Rimini, M. Maslov, E. Alessi, T. Craciunescu, M. Fontana, J.M. Fontdecaba, L. Garzotti, Z. Ghani, L. Horvath, I. Jepu, J. Karhunen, D. Kos, E. Litherland-Smith, A. Meigs, S. Menmuir, R.B. Morales, S. Nowak, E. Peluso, T. Pereira, V. Parail, G. Petravich, G. Pucella, P. Puglia, D. Refy, S. Scully, M. Sertoli, S. Silburn, D. Taylor, B. Thomas, A. Tookey, Ž. Štancar, G. Szepesi, B. Viola, A. Widdowson, E. de la Luna, JET Contributors   +60 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A Study on the Pedestal Structure Analysis of the Shipboard Night Vision System [PDF]

, 2008
In this thesis, we designed Stabilization Pedestal for ship and analyzed the structure and vibration. Stabilization Pedestal must be light in order to support the entire weight barking force when a ship needs a brake, centrifugal force when it is ...
장진석
core  

The role of isotope mass on neutral fueling and density pedestal structure in the DIII-D tokamak

Nuclear Fusion
Experimental measurements on DIII-D of hydrogen neutral penetration lengths ( $\lambda_{n_0}$ ) on the high field side (HFS) are longer by a factor of $\sqrt{2}$ than for deuterium consistent with the thermal velocity ratio for neutrals at the same ...
R.A. Chaban, S. Mordijck, A.M. Rosenthal, A. Bortolon, J.W. Hughes, M. Knolker, F.M. Laggner, T.H. Osborne, L. Schmitz, K.E. Thome, T.M. Wilks   +10 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source