Results 91 to 100 of about 4,914 (248)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Identification of a window for quiescent H-mode operation in MHD stability diagram of DIII-D plasmas

Nuclear Fusion
A window for quiescent H-mode (QH-mode) operation in DIII-D plasmas in the diagram of pedestal magnetohydrodynamic (MHD) stability was identified through linear MHD stability analysis, accounting for the effects of plasma rotation and ion diamagnetic ...
N. Aiba, X. Chen, T.H. Osborne, K.H. Burrell   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Tokamak edge-SOL turbulence in H-mode conditions simulated with a global, electromagnetic, transcollisional drift-fluid model

Nuclear Fusion
The design of commercially feasible magnetic confinement fusion reactors strongly relies on the reduced turbulent transport in the plasma edge during operation in the high confinement mode (H-mode).
Wladimir Zholobenko, Kaiyu Zhang, Andreas Stegmeir, Jan Pfennig, Konrad Eder, Christoph Pitzal, Philipp Ulbl, Michael Griener, Lidija Radovanovic, Ulrike Plank, the ASDEX Upgrade Team   +10 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Facilitated core-edge integration through divertor nitrogen seeding in the HL-2A tokamak

Nuclear Fusion
A divertor detachment with sustainable high-performance plasmas has been achieved through divertor nitrogen seeding in the HL-2A tokamak. The closed divertor structure facilitates achieving high divertor neutral pressure due to its efficient particle ...
N. Wu, J. Cheng, K.Y. Yi, R. Wang, M.K. Han, Z.H. Huang, W.C. Wang, Y. He, L.W. Yan, H.L. Du, J.M. Gao, H.C. Ma, X.X. He, Z.C. Yang, J. Wen, K. Zhang, T. Wu, W.P. Guo, X. Yu, L. Liu, Y.G. Li, L. Nie, Z.B. Shi, D.Z. Wang, W.L. Zhong   +24 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The impact of kinetic and global effects on ideal ballooning 2nd stable pedestals of conventional and low aspect-ratio tokamaks

Nuclear Fusion
The EPED model (Snyder et al 2011 Nucl. Fusion 51 103016) has had success in describing the pedestal structure of Type-I ELM and QH-mode plasmas in tokamaks, by combining kinetic ballooning mode (KBM) and peeling–ballooning (PB) constraints. Within EPED,
M.S. Anastopoulos Tzanis, M. Yang, A. Kleiner, J.F. Parisi, G.M. Staebler, P.B. Snyder   +5 more
doaj   +1 more source