Results 71 to 80 of about 6,875,269 (237)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Sensitivity of echo enabled harmonic generation to sinusoidal electron beam energy structure

Physical Review Accelerators and Beams, 2017
We analytically examine the bunching factor spectrum of a relativistic electron beam with sinusoidal energy structure that then undergoes an echo-enabled harmonic generation (EEHG) transformation to produce high harmonics.
E. Hemsing, B. Garcia, Z. Huang, T. Raubenheimer, D. Xiang   +4 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Development of a two-term model for the confinement in ELMy H-modes using the global confinement and pedestal databases

The overlap of pulses in the pedestal database and the global H-mode confinement database has been increased. This has resulted in a new improved combined dataset with core and pedestal energy data.
Thomsen, K., Martin, Y., Cordey, J.G.
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Empirical impact of near-separatrix plasma and neutral transport on the pedestal in the transition between EDA and ELMy H-modes on Alcator C-Mod

Nuclear Fusion
The transition between the ELMy H-mode and the EDA H-mode is studied on Alcator C-Mod using an experimental database and recently-developed predictive pedestal models.
M.A. Miller, J.W. Hughes, S. Saarelma, T. Eich, J. Dunsmore, J. Han, P. Manz, J.W. Connor, G.R. Tynan, A.E. Hubbard, A. Ho, T. Body, D. Silvagni, O. Grover, S. Mordijck, E.M. Edlund, B. LaBombard, M. Wigram, A. Cavallaro   +18 more
doaj   +1 more source

Analysis of proportional conception of the historical truss Church of St. Martin in Dolní Újezd

MATEC Web of Conferences, 2017
The late-Romanesque St. Martin’s Church in Dolní Újezd was probably built in the mid-13th century. The nave has a wooden joist ceiling whose beams serve as tie beams too. The Gothic vaults above the presbytery date from ’30s of the 15th century.
Krušinský Peter, Holešová Michaela, Racková Eliška   +2 more
doaj   +1 more source