Results 81 to 90 of about 5,885 (271)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Improved optomechanical disk resonator sitting on a pedestal mechanical shield

New Journal of Physics, 2015
We experimentally demonstrate the controlled enhancement of the mechanical quality factor Q of gallium arsenide disk optomechanical resonators. Disks vibrating at 1.3 GHz with a mechanical shield integrated in their pedestal show a Q improvement by a ...
Dac Trung Nguyen, William Hease, Christopher Baker, Eduardo Gil-Santos, Pascale Senellart, Aristide Lemaître, Sara Ducci, Giuseppe Leo, Ivan Favero   +8 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Structural optimization design of an antenna pedestal base

Journal of Physics: Conference Series
Abstract This paper takes an antenna pedestal base as the research object and conducts structural optimization design considering its complex structure and installation conditions. It introduces the structural design, thermal design, and impact resistance design of the pedestal base, analyzes the improved optimization design, proposes
Wei Ma, Xing Ye, Kun Fang
openaire   +1 more source

Impact of ionization and transport on pedestal density structure in DIII-D and Alcator C-Mod

Nuclear Fusion
This paper investigates the role of ionization on the pedestal structure using both measurements and modeling for H-mode plasmas on DIII-D and Alcator C-Mod to enhance our ability to predict pedestal behavior in future pilot plants.
S. Mordijck, R.A. Chaban, R. Reksoatmodjo, J.J. Balbin-Arias, Y. Chuang, J. Loughran, J.W. Hughes, A.M. Rosenthal, M.A. Miller, T. Wilks, F.M. Laggner, T. Osborne   +11 more
doaj   +1 more source

Sensitivity of echo enabled harmonic generation to sinusoidal electron beam energy structure

Physical Review Accelerators and Beams, 2017
We analytically examine the bunching factor spectrum of a relativistic electron beam with sinusoidal energy structure that then undergoes an echo-enabled harmonic generation (EEHG) transformation to produce high harmonics.
E. Hemsing, B. Garcia, Z. Huang, T. Raubenheimer, D. Xiang   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Prediction of DIII-D Pedestal Structure from Externally Controllable Parameters

The sharp increase of pressure at the edge of a high confinement mode (H-mode) plasma, the pedestal, strongly impacts overall plasma performance. Predicting the pedestal is a necessity to control and optimize tokamak operations.
Zeger, Emi U.; Laggner, Florian M.; Bortolon, Alessandro; Rea, Cristina; Meneghini, Orso; Saarelma, Samuli; Sammuli, Brian S.; Smith, Sterling P.; Zhao, Jinjin
core   +1 more source

Observation of a new pedestal stability regime in MAST Upgrade H-mode plasmas

Nuclear Fusion
The first pedestal stability and structure analysis on the new MAST Upgrade (MAST-U) spherical tokamak H-mode plasmas is presented. Our results indicate that MAST-U pedestals are close to the low toroidal mode number ( n ) peeling branch of the peeling ...
K. Imada, T.H. Osborne, S. Saarelma, J.G. Clark, A. Kirk, M. Knolker, R. Scannell, P.B. Snyder, C. Vincent, H.R. Wilson, the MAST Upgrade Team   +10 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source