Results 61 to 70 of about 1,277,806 (307)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Evaluation of Hospitalized Pediatric Patients in Terms of Anemia: Single-Center Experience

Iberoamerican Journal of Medicine
Introduction: Anemia, characterized by reduced hemoglobin and hematocrit levels, affects roughly one-third of the global population and is associated with increased morbidity and mortality.
Emine Ergül Sari, Arzu Kapdan
doaj   +1 more source

Dental Consultations and Treatment Pattern of Pediatric Inpatient in Severance Hospital [PDF]

, 2019
The purpose of this study was to analyze the dental consultation of pediatric inpatients to the department of pediatric dentistry in Yonsei University Severance Hospital, and to investigate the change in patterns.
김성오, 이제호, 이고은, 송제선, 최형준   +4 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Significant Factors Related to Failed Pediatric Dental General Anesthesia Appointments at a Hospital-based Residency Program

, 2017
Purpose: The purposes of this study were to: (1) evaluate the relationship between appointment failure and the factors of age, gender, race, insurance type, day of week, scheduled time of surgery, distance traveled, and weather; (2) investigate reasons ...
Maupome, Gerardo, Eckert, George J., Vinson, LaQuia A., Yepes, Juan F., Kozlowski, Diana C., Emhardt, John D., Jones, James E., Emhardt, John R.   +7 more
core   +1 more source

Construct validity of the pediatric Rome III criteria

, 2014
Functional gastrointestinal disorders (FGIDs) are common. The diagnosis of FGIDs is based on the Rome criteria, a symptom-based diagnostic classification established by expert consensus.
Pusatcioglu, Cenk K., Nichols-Vinueza, Diana X, Mintjens, Stijn, Velasco-Benítez, Carlos A., Nichols-Vinueza, Diana X., Pusatcioglu, Cenk K, Velasco-Benítez, Carlos A, Saps, Miguel   +7 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Efficacy and Safety of Letermovir for Cytomegalovirus Prophylaxis Following Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients

Drug Design, Development and Therapy
Yongbing Zhu,* Li Wang,* Yu Xiang, Yaqin Wang, Ai Zhang, Yao Wang, Mengmeng Yin, Jianxin Dun, Yuting Xu, Qun Hu, Wen Yu,* Aiguo Liu* Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University ...
Zhu Y, Wang L, Xiang Y, Wang Y, Zhang A, Wang Y, Yin M, Dun J, Xu Y, Hu Q, Yu W, Liu A   +11 more
doaj  

Clinical spectrum and clinicopathological correlation of pediatric orbital tumors: 20 years' experience from a tertiary eye care center

Indian Journal of Ophthalmology
Purpose: To study the epidemiological profile of various pediatric orbital tumors and determine their clinicopathological correlation over 20 years. Methods: A retrospective analysis of all pediatric patients with orbital tumors from the medical records ...
Vathsalya Vijay, Md Shahid Alam, Nirmala Subramanian, Subramanian Krishnakumar, Jyotirmay Biswas, Bipasha Mukherjee   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source