Results 161 to 170 of about 1,645,101 (196)

DNA methylation is a comprehensive marker for pediatric adrenocortical tumors

Endocrine-Related Cancer, 2022
Children diagnosed with adrenocortical tumors (pACT) have variable outcomes and, to date, the disease lacks robust prognostic biomarkers. The prognostic potential of tumor methylation has been demonstrated in several cancers. We aimed to evaluate the pACT methylation profile and its association with disease presentation and survival.
Ana Carolina, Bueno, Rui M P, da Silva, Mônica F, Stecchini, Junier, Marrero-Gutiérrez, Danillo C, de Almeida E Silva, Izilda, Cardinalli, Carlos Alberto, Scrideli, Thais, Junqueira, Carlos A F, Molina, Fernando Silva, Ramalho, Silvio, Tucci, Fernanda Borchers, Coeli-Lacchini, Ayrton Custodio, Moreira, Leandra N Z, Ramalho, Silvia, Brandalise, José Andres, Yunes, Margaret, de Castro, Ricardo Zorzetto Nicoliello, Vêncio, Sonir R R, Antonini   +18 more
openaire   +2 more sources

Pediatric adrenocortical tumor – review and management update

Current Opinion in Endocrinology, Diabetes & Obesity, 2020
Purpose of review Adrenocortical tumor (ACT) is a rare disease with an annual worldwide incidence of 0.3–0.38/million children below 15 years old, and Brazilian population presents the highest incidence because of germline mutation in the TP53.
Vania B, Brondani, Maria Candida B V, Fragoso   +1 more
openaire   +2 more sources

Pediatric Adrenocortical Tumors: Clinicopathological Features—An Update

Journal of Pediatric Biochemistry, 2016
Pediatric adrenocortical tumors (ACTs) are rare in children. Most tumors are hormonally active with overproduction of androgens and glucocorticoids, and less frequently mineralocorticoids and estrogens. Patients usually present with clinical signs of virilization or Cushing syndrome, while only a minority of ACTs are incidentally discovered ...
Martino Ruggieri, Pietro Milone
exaly   +3 more sources

Vitamin D receptor hypermethylation as a biomarker for pediatric adrenocortical tumors

European Journal of Endocrinology, 2022
Objective Pediatric adrenocortical tumors (pACT) display complex genomic backgrounds, lacking robust prognostic markers and targeted therapeutic options. Vitamin D3 receptor (VDR) promoter hypermethylation and underexpression were reported in adrenocortical carcinomas from adult patients.
Ana Carolina Bueno, Mônica F Stecchini, Junier Marrero-Gutiérrez, Candy Bellido More, Leticia Ferro Leal, Débora Cristiane Gomes, Daniel Ferreira de Lima Neto, Silvia Regina Brandalise, Izilda Aparecida Cardinalli, José Andres Yunes, Thais Junqueira, Carlos Alberto Scrideli, Carlos Augusto Fernandes Molina, Fernando Silva Ramalho, Silvio Tucci, Fernanda Borchers Coeli-Lacchini, Ayrton Custodio Moreira, Leandra Ramalho, Ricardo Zorzetto Nicoliello Vêncio, Margaret De Castro, Sonir Roberto R Antonini   +20 more
openaire   +2 more sources

Adrenocortical Function in Children With Brain Tumors and Pediatric Hematopoietic Cell Transplantation Recipients

Journal of Pediatric Hematology/Oncology, 2021
Adrenocortical insufficiency (AI) is a clinical condition defined by deficient production of glucocorticoids that can result in life-threatening complications. We examined the prevalence of AI in children with brain tumors and those undergoing hematopoietic cell transplantation.
Koral, Shah, Jennifer W, Boyd, Julia R, Broussard, Kevin, Ginn, Rukhsana, Rahmetulla, Kristy, Hurst, Rakesh K, Goyal   +6 more
openaire   +2 more sources

Histone mRNA in situ hybridization and Ki 67 immunohistochemistry in pediatric adrenocortical tumors

Virchows Archiv Fur Pathologische Anatomie Und Physiologie Und Fur Klinische Medizin, 2006
Adrenocortical tumors in the pediatric population are rare. Classification of these tumors as adenomas or carcinomas using histological criteria is often difficult. Immunohistochemical expressions of proliferative markers are currently under investigation for utilization in the differential diagnosis and prediction of clinical outcomes.
Melda Caglar, Safiye Gogus, Gülsev Kale
exaly   +4 more sources

Diagnosis and Prognosis of Pediatric Patients with Adrenocortical Tumors

2013
Pediatric adrenocortical tumors (ACTs) only rarely occur in children. Unfortunately their clinical behavior is often unpredictable and their diagnosis (benign versus malignant) is still challenging because the pathological criteria of malignancy used in adults (Weiss system) are not always useful in children.
Gaetano Magro, Giada Maria Vecchio, Rita Alaggio   +2 more
openaire   +1 more source

DAX1 Overexpression in Pediatric Adrenocortical Tumors: A Synergic Role with SF1 in Tumorigenesis

Hormone and Metabolic Research, 2015
DAX1 transcription factor is a key determinant of adrenogonadal development, acting as a repressor of SF1 targets in steroidogenesis. It was recently demonstrated that DAX1 regulates pluripotency and differentiation in murine embryonic stem cells. In this study, we investigated DAX1 expression in adrenocortical tumors (ACTs) and correlated it with SF1 ...
G R V, de Sousa, I C, Soares, A M, Faria, V B, Domingues, A, Wakamatsu, A M, Lerario, V A F, Alves, M C N, Zerbini, B B, Mendonca, M C B V, Fragoso, A C, Latronico, M Q, Almeida   +11 more
openaire   +2 more sources

Pediatric adrenocortical tumors: diagnosis, management and advancements in the understanding of the genetic basis and therapeutic implications

Expert Review of Endocrinology and Metabolism, 2014
Adrenocortical tumors (ACTs) may be sporadic or related to inherited genetic syndromes. Uncovering the molecular defects underlying these genetic syndromes has revealed key signaling pathways involved in adrenocortical tumorigenesis. Although the understanding of ACT biology has improved, to date, very few potential prognostic molecular markers of ...
Sonir R Antonini
exaly   +3 more sources

The Endocrine Phenotype Induced by Pediatric Adrenocortical Tumors Is Age- and Sex-Dependent

The Journal of Clinical Endocrinology & Metabolism
Abstract Context Adrenocortical carcinomas are very rare malignancies in childhood associated with poor outcome in advanced disease. Most adrenocortical tumors (ACT) are functional, causing signs and symptoms of adrenal hormone excess.
Marina Kunstreich, Desiree Dunstheimer, Pascal Mier, Paul-Martin Holterhus, Stefan A Wudy, Angela Huebner, Antje Redlich, Michaela Kuhlen   +7 more
openaire   +2 more sources