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Pediatric adrenocortical carcinoma [PDF]

Frontiers in Endocrinology, 2022
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy of the adrenal gland with an unfavorable prognosis. It is rare in the pediatric population, with an incidence of 0.2-0.3 patients per million in patients under 20 years old.
Maran Ilanchezhian, Diana Grace Varghese, John W. Glod, Karlyne M. Reilly, Brigitte C. Widemann, Yves Pommier, Rosandra N. Kaplan, Jaydira Del Rivero   +7 more
doaj   +4 more sources

Radiotherapy for pediatric adrenocortical carcinoma – Review of the literature [PDF]

Clinical and Translational Radiation Oncology, 2022
Background and purpose: Pediatric adrenocortical carcinoma (pACC) is a rare disease with poor prognosis. Publications on radiotherapy (RT) are scarce. This review summarizes the current data on RT for pACC and possibly provides first evidence to justify ...
Verena Wiegering, Maria Riedmeier, Lester D.R. Thompson, Calogero Virgone, Antje Redlich, Michaela Kuhlen, Melis Gultekin, Bilgehan Yalcin, Boris Decarolis, Christoph Härtel, Paul-Gerhardt Schlegel, Martin Fassnacht, Beate Timmermann   +12 more
doaj   +4 more sources

Pediatric Adrenocortical Carcinoma: The Nuts and Bolts of Diagnosis and Treatment and Avenues for Future Discovery [PDF]

Cancer Management and Research
Allison F O’Neill,1 Raul C Ribeiro,2 Emilia M Pinto,3 Michael R Clay,4 Gerard P Zambetti,3 Brent A Orr,3 Christopher B Weldon,5 Carlos Rodriguez-Galindo2,6 1Department of Pediatric Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center,
O'Neill AF, Ribeiro RC, Pinto EM, Clay MR, Zambetti GP, Orr BA, Weldon CB, Rodriguez-Galindo C   +7 more
doaj   +4 more sources

Pediatric adrenocortical carcinoma: clinical features and application of neoadjuvant chemotherapy [PDF]

European Journal of Medical Research, 2023
Objective To summarize the clinical characteristics of children with adrenocortical carcinoma (ACC) and preliminarily explore the indications for and efficacy of neoadjuvant chemotherapy in certain patients.
Yu Lin, Shen Yang, Wei Yang, Haiyan Cheng, Xiaofeng Chang, Zhiyun Zhu, Jun Feng, Jianyu Han, Qinghua Ren, Saishuo Chang, Shan Liu, Tong Yu, Boren Hou, Pengfei Li, Deguang Meng, Xianwei Zhang, Hong Qin, Huanmin Wang   +17 more
doaj   +2 more sources

Pediatric adrenocortical carcinoma revealed by isolated Cushing syndrome: A case report

Journal of Pediatric Surgery Case Reports, 2023
Background: Adrenocortical carcinoma accounts for less than 0.2% of all pediatric malignancies. Virilization is the most common revealing sign, whereas hyperaldosteronism and Cushing syndrome are less common.We report a case of adrenocortical carcinoma ...
Hakima Chafaaoui, Assan Beaudelaire Romulus, Saad Andaloussi, Omar Dalero, Aziz Elmadi   +4 more
doaj   +3 more sources

Mitotane dosage, plasma levels, and anthropometric measurements in pediatric adrenocortical carcinoma [PDF]

Endocrine Oncology
Objective: Mitotane is an effective treatment for advanced adrenocortical carcinoma (ACC). Given the limited pediatric data available, this study aims to evaluate the associations between mitotane dosage, plasma drug levels, and anthropometric ...
Maria Riedmeier, Heidi Frey, Sonir R Antonini, Gabriela Fernandes Luiz Canali, Carl Friedrich Classen, Nerea Domínguez-Pinilla, Martin Fassnacht, Jasmin Finger, Steffen Fuchs, Marika Grönroos, Mariana P Halah, Christoph Härtel, Dominika Janus, Antoinette Jaspers-Bakker, Ronald R de Krijger, Tezer Kutluk, Mouna Mezoued, Jessica Munarin, Max van Noesel, Nihal Özdemir Köse, Simon H Pearce, Thomas Perwein, Soraya Puglisi, Paul-Gerhardt Schlegel, Vera Binder-Blaser, Gerdi Tuli, Justyna Walenciak, Bilgehan Yalcin, Verena Wiegering   +28 more
doaj   +2 more sources

OCT4 and NANOG are involved in adrenocortical tumorigenesis [PDF]

Archives of Endocrinology and Metabolism
Objective: To investigate the involvement of regulators of pluripotency and self-renewal of embryonic stem cells in adrenocortical tumors (ACT). Subjects and methods: Clinicopathological data and tissues from 114 ACT patients (96 pediatric-pACT; 18 ...
Marcelo M. Cavalcanti, Mariana P. Halah, Letícia F. Leal, Fernanda B. Coeli-Lacchini, Carlos A. Scrideli, Carlos A. F. Molina, Jose A. Yunes, Silvia Brandalise, Ayrton C. Moreira, Fernando Ramalho, Leandra N. Ramalho, Margaret de Castro, Sonir R. Antonini   +12 more
doaj   +3 more sources

Pediatric adrenocortical carcinoma complicated by uric acid nephrolithiasis: a unique case report [PDF]

BMC Urology
Background Adrenocortical carcinoma (ACC) is an exceedingly rare malignancy in children, typically presenting with Cushing’s syndrome due to excessive hormone secretion.
Mao Zhang, Wenping Guo, Hengping Li, Xinsheng Xi   +3 more
doaj   +2 more sources

The treatment and prognosis of pediatric adrenocortical carcinoma

Holistic Integrative Oncology
This review comprehensively assesses the treatment modalities and prognostic outcomes of pediatric adrenocortical carcinoma (ACC), a rare malignancy with significant clinical challenges.
Yu Lin, Kairui Zhai, Zhiyun Zhu, Jianyu Han, Shen Yang, Paul D. Losty, Hong Qin   +6 more
doaj   +2 more sources

Artificial Intelligence and Machine Learning in Pediatric Endocrine Tumors: Opportunities, Pitfalls, and a Roadmap for Trustworthy Clinical Translation [PDF]

Biomedicines
Artificial intelligence (AI) and machine learning (ML) are reshaping cancer research and care. In pediatric oncology, early evidence—most robust in imaging—suggests value for diagnosis, risk stratification, and assessment of treatment response. Pediatric
Michaela Kuhlen, Fabio Hellmann, Elisabeth Pfaehler, Elisabeth André, Antje Redlich   +4 more
doaj   +2 more sources