Results 1 to 10 of about 4,784 (129)

Radiotherapy for pediatric adrenocortical carcinoma – Review of the literature

Clinical and Translational Radiation Oncology, 2022
Background and purpose: Pediatric adrenocortical carcinoma (pACC) is a rare disease with poor prognosis. Publications on radiotherapy (RT) are scarce. This review summarizes the current data on RT for pACC and possibly provides first evidence to justify ...
Verena Wiegering, Maria Riedmeier, Lester D.R. Thompson, Calogero Virgone, Antje Redlich, Michaela Kuhlen, Melis Gultekin, Bilgehan Yalcin, Boris Decarolis, Christoph Härtel, Paul-Gerhardt Schlegel, Martin Fassnacht, Beate Timmermann   +12 more
doaj   +3 more sources

CpG hypermethylation and WNT/AP-1 cooperativity define the epigenetic landscape and a clinical subgroup of high-risk pediatric adrenocortical carcinoma [PDF]

Nature Communications
Pediatric adrenocortical tumors are rare, clinically heterogeneous neoplasms with unpredictable outcomes and limited treatment options. Through integrated multi-omic analysis of 214 pediatric adrenocortical tumors combining DNA methylation profiling ...
Victoria E. Fincke, Maurice Loßner, Marina Kunstreich, Nic G. Reitsam, Irmengard Sax, Marlena Mucha, Felix Dorn, Lorenz C. Helmschrott, Maria D. Hernandez Ramirez, Sebastian Dintner, Konstantin Okonechnikov, Martin Sill, Ina Oehme, Heike Peterziel, Enrique Blanco-Carmona, Eva Sipos, Stefan Wudy, Christoph Slavetinsky, Jörg Fuchs, Bruno Märkl, Eva Jüttner, Christian Vokuhl, Michael C. Frühwald, Antje Redlich, Stefan Pfister, Matthias Schlesner, Rainer Claus, Michaela Kuhlen, Pascal D. Johann   +28 more
doaj   +2 more sources

Pediatric Pheochromocytoma With Rapid Cyclic Blood Pressure Fluctuations: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Cyclic blood pressure fluctuations in pheochromocytoma are extremely rare, and previously reported cases have been limited to adults. We report a 5‐year‐old boy with von Hippel–Lindau disease and a left adrenal pheochromocytoma who developed rapid cyclic blood pressure fluctuations immediately after tracheal intubation.
Yamazaki K, Maeda C, Morikawa K, Okamoto N.   +3 more
europepmc   +2 more sources

Pediatric adrenocortical carcinoma

Frontiers in Endocrinology, 2022
Adrenocortical carcinoma (ACC) is a rare endocrine malignancy of the adrenal gland with an unfavorable prognosis. It is rare in the pediatric population, with an incidence of 0.2-0.3 patients per million in patients under 20 years old.
Maran Ilanchezhian, Diana Grace Varghese, John W. Glod, Karlyne M. Reilly, Brigitte C. Widemann, Yves Pommier, Rosandra N. Kaplan, Jaydira Del Rivero   +7 more
doaj   +3 more sources

Mitotane dosage, plasma levels, and anthropometric measurements in pediatric adrenocortical carcinoma [PDF]

Endocrine Oncology
Objective: Mitotane is an effective treatment for advanced adrenocortical carcinoma (ACC). Given the limited pediatric data available, this study aims to evaluate the associations between mitotane dosage, plasma drug levels, and anthropometric ...
Maria Riedmeier, Heidi Frey, Sonir R Antonini, Gabriela Fernandes Luiz Canali, Carl Friedrich Classen, Nerea Domínguez-Pinilla, Martin Fassnacht, Jasmin Finger, Steffen Fuchs, Marika Grönroos, Mariana P Halah, Christoph Härtel, Dominika Janus, Antoinette Jaspers-Bakker, Ronald R de Krijger, Tezer Kutluk, Mouna Mezoued, Jessica Munarin, Max van Noesel, Nihal Özdemir Köse, Simon H Pearce, Thomas Perwein, Soraya Puglisi, Paul-Gerhardt Schlegel, Vera Binder-Blaser, Gerdi Tuli, Justyna Walenciak, Bilgehan Yalcin, Verena Wiegering   +28 more
doaj   +2 more sources

Successful transcatheter arterial embolization for ruptured adrenocortical tumor in a pediatric patient

Radiology Case Reports, 2021
Adrenocortical tumors (ACTs) are rare in children and should be treated as malignant tumors. A 12-year-old female patient was referred to our institute for acute abdomen and hypovolemic shock.
Miki Yoshida, MD, Hiroaki Takahashi, MD, Yuni Yamaki, MD, Fumiko Chiba, MD, Kensaku Mori, MD   +4 more
doaj   +3 more sources

Case Report: Androgen-secreting pediatric adrenocortical tumor of uncertain malignant potential presenting with virilization in a 19-month-old girl [PDF]

Frontiers in Endocrinology
BackgroundVirilization in girls younger than 2 years should prompt careful evaluation for pathological androgen excess and should be interpreted as a practical clinical reminder rather than as a stand-alone diagnostic tool.
Yirong Wang, Yirong Wang, Bo Sun, Xiangyue Lu, Tongmin Li, Mei Han, Hongbin Hou   +6 more
doaj   +2 more sources

Artificial Intelligence and Machine Learning in Pediatric Endocrine Tumors: Opportunities, Pitfalls, and a Roadmap for Trustworthy Clinical Translation [PDF]

Biomedicines
Artificial intelligence (AI) and machine learning (ML) are reshaping cancer research and care. In pediatric oncology, early evidence—most robust in imaging—suggests value for diagnosis, risk stratification, and assessment of treatment response. Pediatric
Michaela Kuhlen, Fabio Hellmann, Elisabeth Pfaehler, Elisabeth André, Antje Redlich   +4 more
doaj   +2 more sources

Functional and behavioral outcomes in pediatric adrenal carcinoma under mitotane therapy: a caregiver-reported pilot study [PDF]

Endocrine Oncology
Objective: Mitotane is the standard therapy for advanced pediatric adrenocortical carcinoma (pACC). With improving survival, treatment-related long-term side effects and their impact on everyday functioning are becoming increasingly relevant.
Heidi Frey, Maria Riedmeier, Johanna Krüger, Carl Friedrich Classen, Nerea Domínguez-Pinilla, Maria Fragoso, Steffen Fuchs, Dominika Janus, Mouna Mezoued, Andrea Mocna, Jessica Munarin, Soraya Puglisi, Hilal Susam Sen, Gerdi Tuli, Justyna Walenciak, Bilgehan Yalcin, Martin Fassnacht, Verena Wiegering   +17 more
doaj   +2 more sources

Precocious puberty in a child: A rare cause and review of literature

Journal of Family Medicine and Primary Care, 2022
Precocious puberty (PP) in pediatric office practice is challenging as the cause varies from benign to malignant conditions. Adrenocortical tumors are rare in childhood and pseudo-precocious puberty is the most common clinical presentation in children ...
Thulasiraj Saminathan, J Dhivyalakshmi, Latha M Sneha, Leena D Joseph   +3 more
doaj   +1 more source