Results 31 to 40 of about 1,645,101 (196)

Extramitochondrial OPA1 and adrenocortical function [PDF]

, 2013
We have previously described that silencing of the mitochondrial protein OPA1 enhances mitochondrial 27 Ca2+ signaling and aldosterone production in H295R adrenocortical cells.
Fülöp, László, Spät András, Szanda, Gergö, Katona, Dávid, Rajki Anikó, Rajki, Anikó, Fülöp László, Szanda Gergő, Spät, András, Katona Dávid   +9 more
core   +2 more sources

Impairment of adrenocortical function associated with increased plasma tumor necrosis factor-alpha and interleukin 6 concentrations in African trypanosomiasis [PDF]

, 1994
African sleeping sickness (SS) is a severe, potentially lethal parasitic disease. The treatments of choice are the antiparasitic agents suramin, which is adrenotoxic, and/or melarsoprol. We evaluated the functional integrity of the hypothalamic-pituitary-
Winkelmann, W., Reincke, M, Allolio, B., Siekmann, L., Heppner, C, Arlt, W, Petzke, F, Arlt, W., Mbulamberi, D, Vollmer, D, Chrousos, G. P., Allolio, B, Siekmann, L, Vollmer, D., Heppner, C., Mbulamberi, D., Winkelmann, W, Reincke, Martin, Petzke, F., Chrousos, G P   +19 more
core   +2 more sources

Adrenocortical Tumors and Pheochromocytoma/Paraganglioma Initially Mistaken as Neuroblastoma—Experiences From the GPOH-MET Registry

Frontiers in Endocrinology, 2022
In children and adolescents, neuroblastoma (NBL), pheochromocytoma (PCC), and adrenocortical tumors (ACT) can arise from the adrenal gland. It may be difficult to distinguish between these three entities including associated extra-adrenal tumors ...
Michaela Kuhlen, Christina Pamporaki, Marina Kunstreich, Stefan A. Wudy, Michaela F. Hartmann, Mirko Peitzsch, Christian Vokuhl, Guido Seitz, Michael C. Kreissl, Thorsten Simon, Barbara Hero, Michael C. Frühwald, Peter Vorwerk, Antje Redlich   +13 more
doaj   +1 more source

Tumor DNA Methylation Profiling Is a Robust and Independent Prognostic Marker for Pediatric Patients With Adrenocortical Tumors [PDF]

Journal of the Endocrine Society, 2021
Abstract Pediatric adrenocortical tumors (pACTs) display complex genomic background and lack robust prognostic biomarkers. However, pACT methylation profiling was recently associated with patient prognosis. In order to evaluate whether tumor DNA methylation is associated with patient prognosis, we studied a Brazilian cohort of pACT in ...
Ana Carolina Bueno, Rui Milton Patrício da Silva-Júnior, Monica Freire Stecchini, Junier Marrero Gutiérrez, Izilda Aparecida Cardinalli, Carlos Alberto Scrideli, Carlos Augusto Fernandes Molina, Fernando Silva Ramalho, Silvio Tucci, Fernanda Borchers Coeli-Lacchini, Ayrton Custodio Moreira, Leandra Naira Zambelli Ramalho, Silvia Regina Brandalise, Jose Andres Yunes, Margaret De Castro, Ricardo Zorzetto Nicoliello Vencio, Sonir Roberto Rauber Antonini   +16 more
openaire   +1 more source

Adrenocortical tumors associated with the TP53 p.R337H germline mutation can be identified during child-care consultations

Jornal de Pediatria, 2018
Objective: To evaluate the clinical features associated with adrenocortical hormone overexpression and familial cancer profiling as potential markers for early detection of adrenocortical tumors in children from South and Southeast Brazil.
Maria J. Mastellaro, Raul C. Ribeiro, Antônio G. Oliveira-Filho, Ana L. Seidinger, Izilda A. Cardinalli, Eliana C.M. Miranda, Simone S. Aguiar, Silvia R. Brandalise, José A. Yunes, Antônio A. Barros-Filho   +9 more
doaj   +3 more sources

Heterosexual precocity: rare manifestation of virilizing adrenocortical oncocytoma

Annals of Saudi Medicine, 2013
Adrenocortical oncocytomas are extremely rare, and most of the tumors are benign and nonfunctioning. To our knowledge, only 30 cases have been reported in English published studies, and most patients are 40 to 60 years of age.
Sridhar Subbiah, Uma Nahar, Ram Samujh, Anil Bhansali   +3 more
doaj   +1 more source

Embolization in an adrenocortical carcinoma as palliative therapy [PDF]

, 1999
Background: With an annual incidence of 0.2% of new cases per 100,000 inhabitants, adrenocortical carcinoma is rare. In advanced tumor only palliative treatment modalities are practicable. Because of scarcity of the tumor, standard treatment has not been
Kühl, M., Forstpointner, Roswitha, Braunschweig, R., Schalhorn, Andreas, Lang, N., Meissner, H., H. Meißner, M. Kühl, N. Lang, A. Schalhorn, R. Forstpointner, R. Braunschweig   +11 more
core   +1 more source

Li-Fraumeni syndrome: Adrenal cortical tumor in a newborn followed by a choroid plexus tumor

Journal of Pediatric Surgery Case Reports, 2018
Adrenocortical tumors (ACTs) are rare in children, comprising
Jamie E. Anderson, Rebecca A. Stark
doaj   +1 more source

Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R [PDF]

, 2013
Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic options. Activating β-catenin somatic mutations are found in ACC and have been associated with a poor clinical outcome. In fact, activation of the
Lucile Lefèvre, Ragazzon, Bruno, Constanze Hantel (280561), Guillaud-Bataille, Marine, Bruno Ragazzon (140444), Launay, Pierre, Stéphane Bonnet (280565), Marthe Rizk-Rabin (280575), Marine Guillaud-Bataille (9131), Karine Perlemoine, Lefèvre, Lucile, Sébastien Gaujoux (280559), Tissier, Frédérique, Hantel, Constanze, Frédérique Tissier (140448), Lucile Lefèvre (280570), Rizk-Rabin, Marthe, Karine Perlemoine (280567), Bertherat, Jérôme, Stéphane Bonnet, Bonnet, Stéphane, Sébastien Gaujoux, Perlemoine, Karine, Jérôme Bertherat, Bruno Ragazzon, Beuschlein, Felix, Marthe Rizk-Rabin, Frédérique Tissier, Pierre Launay (280563), Jérôme Bertherat (140471), Felix Beuschlein, Marine Guillaud-Bataille, Constanze Hantel, Felix Beuschlein (158361), Gaujoux, Sébastien, Pierre Launay   +35 more
core   +1 more source

Clonal Composition of Human Adrenocortical Neoplasms [PDF]

, 1994
The mechanisms of tumorigenesis of adrenocortical neoplasms are still not understood. Tumor formation may be the result of spontaneous transformation of adrenocortical cells by somatic mutations.
Travis, W., Beuschlein, Felix, Karl, M., Chrousos, G. P., Abdelhamid, S., Allolio, B., Jaursch-Hancke, C., Reincke, Martin   +7 more
core   +1 more source