Results 21 to 30 of about 1,645,101 (196)

Surgical approach to an adrenocortical carcinoma with right atrial extension in a nine-year old male: Our experience

Journal of Pediatric Surgery Case Reports, 2020
Adrenocortical carcinoma with intracaval and intra atrial extension is an extremely rare occurrence in the pediatric population. We report the case of a nine‐year‐old male who presented to our outpatient department with facial swelling, weight gain, and ...
Ayesha Saleem, Sarah Jeelani, Zain Baig, Muhammad Arshad   +3 more
doaj   +1 more source

Pediatric adrenal incidentaloma [PDF]

Romanian Journal of Pediatrics, 2021
The term of “incidentaloma” involves multiple disciplines of the medicine, especially on the era of modern medicine with massive progress of investigations tools that increased the epidemiological implications of this entity.
Mihai Cristian Dumitrascu, Alice Elena Ghenea, Mihaela Popescu, Anda Dumitrascu, Mara Carsote, Claudia Mehedintu, Florica Sandru   +6 more
doaj   +1 more source

Germline Variants in Phosphodiesterase Genes and Genetic Predisposition to Pediatric Adrenocortical Tumors [PDF]

Cancers, 2020
Phosphodiesterases (PDEs) form a superfamily of enzymes that catalyze the hydrolysis of cyclic nucleotides adenosine 3′5′-cyclic monophosphate (cAMP) and guanosine 3′5′-cyclic monophosphate (cGMP) to their inactive 5′ monophosphates. cAMP plays a critical role as a second messenger in endocrine tissues, and activation of cAMP signaling has been ...
Emilia Modolo Pinto, Fabio R. Faucz, Luana Z. Paza, Gang Wu, Elizabeth S. Fernandes, Jerome Bertherat, Constantine A. Stratakis, Enzo Lalli, Raul C. Ribeiro, Carlos Rodriguez-Galindo, Bonald C. Figueiredo, Gerard P. Zambetti   +11 more
openaire   +3 more sources

Occurrence of Neuroblastoma among TP53 p.R337H Carriers. [PDF]

PLoS ONE, 2015
The high incidence of adrenocortical tumors and choroid plexus carcinoma in children from South and Southeastern regions of Brazil is associated with the germline p.R337H mutation of TP53 gene.
Ana Luiza Seidinger, Fernanda Paschoal Fortes, Maria José Mastellaro, Izilda Aparecida Cardinalli, Lilian Girotto Zambaldi, Simone Santos Aguiar, José Andrés Yunes   +6 more
doaj   +1 more source

Genotype analysis of the human endostatin variant p.D104N in benign and malignant adrenocortical tumors

Clinics, 2012
OBJECTIVE: Endostatin is a potent endogenous inhibitor of angiogenesis. It is derived from the proteolytic cleavage of collagen XVIII, which is encoded by the COL18A1 gene. A polymorphic COL18A1 allele encoding the functional polymorphism p.D104N impairs
Beatriz Marinho de Paula Mariani, Ericka Barbosa Trarbach, Tamaya Castro Ribeiro, Maria Adelaide Albergaria Pereira, Berenice Bilharinho Mendonca, Maria Candida Barisson Villares Fragoso   +5 more
doaj   +1 more source

Feminizing Adrenocortical Tumors as a Rare Etiology of Isosexual/Contrasexual Pseudopuberty

JCRPE, 2022
INTRODUCTION: Estrogen-secreting adrenocortical tumors (ACTs) are quite rare with feminizing adrenocortical tumors (FATs) accounting for 0.37-2% of all ACTs.
Doğuş Vurallı, Nazlı Gönç, Alev Özön, Saniye Ekinci, H. Serkan Doğan, Serdar Tekgül, Ayfer Alikaşifoğlu   +6 more
doaj   +1 more source

Venous Tumor Thrombosis and Pulmonary Metastases in a Case of Adrenal Neuroblastoma—Occurrence of Two Rare Manifestations in a Single Patient: Case Report and Review of Literature

Journal of Gastrointestinal and Abdominal Radiology, 2020
Unlike other pediatric extra cranial solid neoplasms, neuroblastomas have very low incidence of pulmonary metastases. Neuroblastomas also tend to encase rather than infiltrate the major vessels with very low incidence of tumor thrombus.
Somesh Singh, Seema Kembhavi, Sneha Shah, Tushar Vora, Girish Chinnaswamy, Sajid Qureshi   +5 more
doaj   +1 more source

Adrenocortical tumors in children: Sri Lankan experience from a single center, and a mini review

Journal of Medical Case Reports, 2023
Background Pediatric adrenocortical tumors include both benign adenomas and highly virulent malignant tumors. However, they are very rare among children.
Naotunna Palliya Guruge Chamidri Randika Naotunna, Harankaha Vidanalage Dinendra Nishadini Siriwardana, Balagamage Chamila Lakmini, Dilhara Senani Gamage, Sandani Gunarathna, Malik Samarasinghe, Sanjeewa Gunasekara, Navoda Atapattu   +7 more
doaj   +1 more source

Long-term survival outcomes of pediatric adrenal malignancies: An analysis with the upstaged SEER registry during 2000-2019

Frontiers in Endocrinology, 2022
ObjectiveTo investigate the clinicopathological characteristics and long-term survival outcomes of pediatric adrenal malignancies.MethodThis study retrospectively analyzed children with pathologically confirmed pediatric adrenal malignancies from ...
Zemin Lv, Yunyun Yu, Yangmei Luo, Song Lin, Xuang Xiang, Xiaowen Mao, Shigang Cheng   +6 more
doaj   +1 more source

Interpretable Machine Learning Model for Survival Prediction in Pediatric Adrenocortical Tumors. [PDF]

J Endocr Soc
Abstract Purpose Pediatric adrenocortical tumors (pACTs) are rare and clinically heterogeneous. Existing risk stratification systems rely on fixed thresholds and linear assumptions, which may limit their prognostic accuracy—particularly for nonmetastatic, locally advanced cases.
Redlich A, Pfaehler E, Kunstreich M, Schmutz M, Slavetinsky C, Jüttner E, Holterhus PM, Warncke G, Vokuhl C, Fuchs J, Wudy SA, Kuhlen M.   +11 more
europepmc   +3 more sources