Results 41 to 50 of about 1,645,101 (196)

Emotional and Adrenocortical Responses of Infants to the Strange Situation: The Differential Function of Emotional Expression [PDF]

, 1998
The aim of the study was to investigate biobehavioural organisation in infants with different qualities of attachment. Quality of attachment (security and disorganisation), emotional expression, and adrenocortical stress reactivity were investigated in a
Schieche, Michael, Spangler, Gottfried
core   +1 more source

No evidence for oncogenic mutations in guanine nucleotide-binding proteins of human adrenocortical neoplasms [PDF]

, 1933
G-Proteins are membrane-bound heterotrimeric polypeptides that couple receptor signals to second messenger systems such as cAMP. Recently, point mutations at 2 codons of the highly preserved alpha-chain of Gs, the adenyl cyclase-stimulating G-protein ...
Travis, W., Karl, M., Chrousos, G. P., Reincke, Martin   +3 more
core   +1 more source

Histopathological and Molecular Characteristics of Pediatric Adrenocortical Tumors: where Do we Stand? [PDF]

Endocr Pathol
Abstract Pediatric adrenal cortical carcinoma (ACC) is a rare heterogeneous cancer type that is incompletely understood and differs from its adult counterpart in clinical presentation, histopathological characteristics, genomic landscape, and prognosis.
Swart CC, de Krijger RR.
europepmc   +3 more sources

Genomic landscape of paediatric adrenocortical tumours [PDF]

Nature Communications, 2015
Paediatric adrenocortical carcinoma is a rare malignancy with poor prognosis. Here we analyse 37 adrenocortical tumours (ACTs) by whole-genome, whole-exome and/or transcriptome sequencing. Most cases (91%) show loss of heterozygosity (LOH) of chromosome 11p, with uniform selection against the maternal chromosome. IGF2 on chromosome 11p is overexpressed
Emilia M. Pinto, Xiang Chen, John Easton, David Finkelstein, Zhifa Liu, Stanley Pounds, Carlos Rodriguez-Galindo, Troy C. Lund, Elaine R. Mardis, Richard K. Wilson, Kristy Boggs, Donald Yergeau, Jinjun Cheng, Heather L. Mulder, Jayanthi Manne, Jesse Jenkins, Maria J. Mastellaro, Bonald C. Figueiredo, Michael A. Dyer, Alberto Pappo, Jinghui Zhang, James R. Downing, Raul C. Ribeiro, Gerard P. Zambetti   +23 more
openaire   +4 more sources

Uncovering p53 Mutations and Abnormal Gene Expression in Pediatric Adrenocortical Cancer [PDF]

, 2007
Pediatric adrenocortical cancer is extremely rare and often fatal (approximately 0.3-0.4 cases per million worldwide; 50% 5-year survival). The incidence of pediatric adrenocortical cancer in southern Brazil is 10-15 times higher than the worldwide ...
West, Alina Nico
core   +1 more source

P53 mutations in human adrenocortical neoplasms [PDF]

, 1994
The mechanisms of tumorigenesis of adrenocortical neoplasms have not been elucidated as yet. However, loss of heterozygosity at chromosomal locus 17p has been consistently observed in adrenocortical cancer.
Travis, W., Linehan, M., Karl, M., Chrousos, G. P., Allolio, B., Mastorakis, G., Reincke, Martin   +6 more
core   +1 more source

Pediatric Adrenocortical Tumors: What They Can Tell Us on Adrenal Development and Comparison with Adult Adrenal Tumors [PDF]

Frontiers in Endocrinology, 2015
Adrenocortical tumors (ACT) in children are very rare and are most frequently diagnosed in the context of the Li-Fraumeni syndrome, a multiple cancer syndrome linked to germline mutations of the tumor suppressor gene TP53 with loss of heterozygosity in the tumors.
Lalli, Enzo, Figueiredo, Bonald C.
openaire   +3 more sources

Pan-cancer atlas of somatic core and linker histone mutations

npj Genomic Medicine, 2023
Recent genomic data points to a growing role for somatic mutations altering core histone and linker histone-encoding genes in cancer. However, the prevalence and the clinical and biological implications of histone gene mutations in malignant tumors ...
Erin R. Bonner, Adam Dawood, Heather Gordish-Dressman, Augustine Eze, Surajit Bhattacharya, Sridevi Yadavilli, Sabine Mueller, Sebastian M. Waszak, Javad Nazarian   +8 more
doaj   +1 more source

New evidences on the regulation of SF-1 expression by POD1/TCF21 in adrenocortical tumor cells

Clinics
OBJECTIVES: Transcription Factor 21 represses steroidogenic factor 1, a nuclear receptor required for gonadal development, sex determination and the regulation of adrenogonadal steroidogenesis.
Monica Malheiros França, Antonio M. Lerario, Maria Candida B.V. Fragoso, Claudimara Ferini Pacicco Lotfi   +3 more
doaj   +1 more source

OR02-1 DNA Methylation Profiling in Pediatric Adrenocortical Tumors Reveals Distinct Methylation Signatures with Prognostic Significance: A Report from the International Pediatric Adrenocortical Tumor Registry

J Endocr Soc, 2019
Pediatric adrenocortical tumors (ACTs) are heterogeneous and have a poor prognosis. Overall survival is around 60%. In pediatric ACT that is managed only with surgery, features associated with adverse outcome include age greater than 3 years, non-functioning tumors, and metastatic (Stage IV) or residual tumor after surgery (Stage III).
Clay M, Pinto E, Cline C, Tran Q, Lin T, Wu H, Azzato E, Pappo A, Dyer M, Pounds S, Ellison D, Zambetti G, Orr B, Ribeiro R.   +13 more
europepmc   +2 more sources