Adrenocortical carcinoma: Pediatric aspects (Review).
Experimental and Therapeutic Medicine, 2022 Adrenocortical carcinoma (adrenal cortex-derived cancer), an orphan malignancy, is a very aggressive disease that affects both adults and children with an annual incidence of 1-2 adult and 0.2-0.38 pediatric cases/million (in the pediatric population it ...
F. Șandru +5 more
semanticscholar +4 more sources
Penetrance of the TP53 R337H Mutation and Pediatric Adrenocortical Carcinoma Incidence Associated with Environmental Influences in a 12-Year Observational Cohort in Southern Brazil. [PDF]
Cancers (Basel), 2019 The TP53 R337H mutation is associated with increased incidence of pediatric adrenocortical tumor (ACT). The different environmental conditions where R337H carriers live have not been systematically analyzed.
Costa TEJ +46 more
europepmc +2 more sources
Pediatric Mixed Functioning Adrenocortical Carcinoma: A Case Report and Review of Literature [PDF]
Middle East Journal of Cancer, 2019 Adrenocortical carcinoma (ACC) is a very rare disease in the pediatric age group. The clinic-biological profile, histopathological criteria of diagnosis, and staging of this disease in this age group are different from those of adult ACC.
Sanjay Yadav +4 more
doaj +2 more sources
Artificial Intelligence and Machine Learning in Pediatric Endocrine Tumors: Opportunities, Pitfalls, and a Roadmap for Trustworthy Clinical Translation [PDF]
BiomedicinesArtificial intelligence (AI) and machine learning (ML) are reshaping cancer research and care. In pediatric oncology, early evidence—most robust in imaging—suggests value for diagnosis, risk stratification, and assessment of treatment response. Pediatric
Michaela Kuhlen +4 more
doaj +2 more sources
Pediatric Adrenocortical Carcinoma: Diagnostic Challenges and Therapeutic Approach — A Case Report
Iranian Journal of Pediatric Hematology & OncologyAdrenocortical carcinoma (ACC) is a rare tumor. It constitutes 0.2% of malignant tumors in children and it is considered ten times rarer than in adults. Patients with predisposing syndromes like Li-Fraumeni or Beckwith-Wiedemann may develop these tumors.
Assia Haif, Djelloul Achouri
semanticscholar +2 more sources
Regarding the Children's Oncology Group ARAR0332 Protocol for Pediatric Adrenocortical Carcinoma. [PDF]
Journal of Clinical Oncology, 2021 Ji-gan Wang, Dun-Chang Mo
semanticscholar +3 more sources
Adrenocortical carcinoma in a pediatric patient with li-fraumeni-like Syndrome: an endemic condition in southern Brazil [PDF]
Clinical and Biomedical Research, 2021 A 12-year-old boy with germline TP53-R337H mutation and family history of early adrenocortical carcinoma (ACC) was admitted to hospital with abdominal pain and distention.
Mariana Mendes Knabben +4 more
doaj +4 more sources
Pediatric Hematology Oncology JournalBackground: Mitotane is employed as adjuvant therapy in managing adrenocortical carcinoma in pediatric patients. While various adverse effects, such as estrogen-like manifestations, are well-documented in adults, there is limited knowledge regarding ...
Maria Riedmeier +16 more
doaj +3 more sources
3 QUESTIONS ON... Optimizing Treatment for Pediatric Adrenocortical Carcinoma
Oncology Times, 2021 Sarah DiGiulio
semanticscholar +3 more sources
Double heterozygous pathogenic variants in BRCA2 and CHEK2 in a girl with adrenocortical carcinoma [PDF]
Exploration of Endocrine and Metabolic DiseasesPediatric adrenocortical tumors (pACTs) are rare endocrine neoplasms with variable prognosis, commonly associated with germline pathogenic variants (PVs) in the tumor suppressor gene TP53. Here, we report the case of a 3.1-year-old female presenting with
Victoria E. Fincke +9 more
doaj +2 more sources