Results 31 to 40 of about 19,884 (196)

Rare but not forgotten: Therapeutic advancements for rare childhood cancers [PDF]

Molecular Therapy: Oncology
Cancers in children represent less than 1% of all new cases of cancer. While all cancers are rare during childhood, certain types are particularly rare. Multi-institutional pediatric trials and coordinated efforts between pediatric and adult groups have ...
Jacquelyn N. Crane, Urania Dagalakis, Robyn D. Gartrell, Kris Ann P. Schultz, Theodore W. Laetsch   +4 more
doaj   +2 more sources

Integrative Genomic Profiling of Pediatric Solid Tumors Reveals Clinically Relevant Variants and Chromosomal Arm Aneuploidies Signatures. [PDF]

Cancer Med
ABSTRACT Background Pediatric malignancies have emerged as the leading cause of disease‐related mortality in children, exhibiting distinct etiological and molecular characteristics compared to adult cancers. Despite advances in genomic profiling, the molecular landscape of pediatric solid tumors, particularly in Chinese populations, remains ...
Yan B, Wang J, Xiong J, Liu S, Tang Y, He Z, Yan H, Guo B, Chen C, Zhang Y, Zhu Q, Cai J, He M, Wu X, Mao J, Zhang L, Gu W, Zhu Z, Li Z, Xiao R, Shu Q, Yu G, Tao T.   +22 more
europepmc   +2 more sources

Inhibin alpha-subunit (INHA) expression in adrenocortical cancer is linked to genetic and epigenetic INHA promoter variation [PDF]

, 2014
Adrenocortical carcinoma (ACC) is a rare, but highly malignant tumor of unknown origin. Inhibin α-subunit (Inha) knockout mice develop ACCs following gonadectomy.
Feelders, R.A. (Richard), Herder, W.W. (Wouter) de, Hofland, J. (Johannes), Hofland, L.J. (Leo), Jong, F.H. (Frank) de, Krijger, R.R. (Ronald) de, Steenbergen, J. (Jacobie), Uitterlinden, A.G. (André), Verbiest, M.M.P.J. (Michael), Voorsluijs, J.M. (Jacoba)   +9 more
core   +20 more sources

Precocious puberty in a child: A rare cause and review of literature

Journal of Family Medicine and Primary Care, 2022
Precocious puberty (PP) in pediatric office practice is challenging as the cause varies from benign to malignant conditions. Adrenocortical tumors are rare in childhood and pseudo-precocious puberty is the most common clinical presentation in children ...
Thulasiraj Saminathan, J Dhivyalakshmi, Latha M Sneha, Leena D Joseph   +3 more
doaj   +1 more source

Pediatric adrenal incidentaloma [PDF]

Romanian Journal of Pediatrics, 2021
The term of “incidentaloma” involves multiple disciplines of the medicine, especially on the era of modern medicine with massive progress of investigations tools that increased the epidemiological implications of this entity.
Mihai Cristian Dumitrascu, Alice Elena Ghenea, Mihaela Popescu, Anda Dumitrascu, Mara Carsote, Claudia Mehedintu, Florica Sandru   +6 more
doaj   +1 more source

Surgical approach to an adrenocortical carcinoma with right atrial extension in a nine-year old male: Our experience

Journal of Pediatric Surgery Case Reports, 2020
Adrenocortical carcinoma with intracaval and intra atrial extension is an extremely rare occurrence in the pediatric population. We report the case of a nine‐year‐old male who presented to our outpatient department with facial swelling, weight gain, and ...
Ayesha Saleem, Sarah Jeelani, Zain Baig, Muhammad Arshad   +3 more
doaj   +1 more source

Adrenocortical carcinoma (ACC) with massive liver metastases in a 4-year-old female patient: the significance of chemotherapy and imaging studies in treatment and diagnosis – a case report

Journal of Education, Health and Sport, 2023
Background: Adrenocortical carcinoma (ACC) is a retroperitoneal tumour, accounting for less than 0.2% of all malignancies in children. In pediatric patients, the most common clinical presentation is virilisation, either isolated or in combination with ...
Aneta Głaz, Damian Wach, Joanna Mitek-Palusińska, Magdalena Woźniak   +3 more
doaj   +1 more source

Occurrence of Neuroblastoma among TP53 p.R337H Carriers. [PDF]

PLoS ONE, 2015
The high incidence of adrenocortical tumors and choroid plexus carcinoma in children from South and Southeastern regions of Brazil is associated with the germline p.R337H mutation of TP53 gene.
Ana Luiza Seidinger, Fernanda Paschoal Fortes, Maria José Mastellaro, Izilda Aparecida Cardinalli, Lilian Girotto Zambaldi, Simone Santos Aguiar, José Andrés Yunes   +6 more
doaj   +1 more source

Pediatric adrenal incidentaloma as a rare and difficult to diagnose finding - review

Journal of Education, Health and Sport, 2022
Adrenal incidentaloma (AI) is an asymptomatic mass localized in the adrenal gland, usually detected during diagnostic imaging performed due to other health issues than the suspected adrenal disease.
Dominika Pałac, Magdalena Ostrowska, Magdalena Grześk-Kaczyńska, Szymon Kaczyński   +3 more
doaj   +1 more source

Aspectos clínicos e moleculares de tumor adrenocortical metacrônico pediátrico [PDF]

, 2011
The occurrence of metachronous adrenocortical carcinoma has rarely been described. We report a case of a child with virilizing adrenocortical metachronous tumors that, despite several metastases, presented long-term survival (15 years).
ALENCAR, Guilherme Asmar, ALMEIDA, Madson Queiroz, BRITO, Luciana Pinto, DOMENICE, Sorahia, FRAGOSO, Maria Candida Barrison Villares, LATRONICO, Ana Claudia, LERARIO, Antonio Marcondes, LIMA, Lorena de Oliveira, MENDONCA, Berenice Bilharinho   +8 more
core   +2 more sources