Results 11 to 20 of about 1,054,709 (177)

Inflammation-based score in pediatric adrenocortical carcinoma. [PDF]

Endocr Relat Cancer
Abstract Inflammation-based scores have been demonstrated to be independent prognostic factors in predicting outcomes in adult adrenocortical carcinoma (ACC). We aimed to investigate the prognostic role of these scores in pediatric adrenocortical carcinoma (pACC) patients.
Riedmeier M, Idkowiak J, Frey H, Antonini SRR, Canali GFL, Classen CF, Domínguez-Pinilla N, Fassnacht M, Fuchs S, Härtel C, Janús D, de Krijger R, Kutluk T, Bui NL, Meena JP, Mezoued M, Munarin J, van Noesel MM, Köse NÖ, Pearce SH, Perwein T, Puglisi S, Del Rivero J, Schlegel PG, Schmid I, Tuli G, Walenciak J, Yalcin B, Wiegering V.   +28 more
europepmc   +14 more sources

Pharmacokinetic variability of mitotane in pediatric adrenocortical carcinoma and the role of CYP2B6 genotypes: a pediatric case series

EJC Paediatric Oncology
Despite therapeutic drug monitoring of mitotane, achieving target plasma concentrations remains challenging. Commonly reported enzymes involved in mitotane metabolism are cytochrome P450 (CYP)3A4 and 2B6, with CYP2B6 being highly polymorphic.
Ivy A.E. Ankone, Tirsa de Kluis, Lidwien M. Hanff, Antoinette Jaspers-Bakker, Ronald R. de Krijger, Jesse J. Swen, Kathalijne A. Oudhoff, Marieke J.M. Meijs, Max M. van Noesel, Alwin D.R. Huitema, Meta H.M. Diekstra   +10 more
doaj   +5 more sources

Factors associated with survival in pediatric adrenocortical carcinoma: An analysis of the National Cancer Data Base (NCDB) [PDF]

Journal of Pediatric Surgery, 2016
Adrenocortical carcinoma (ACC) is a rare tumor in children with important distinctions from the adult disease. We reviewed the National Cancer Data Base (NCDB) to determine factors associated with long-term survival.The NCDB was queried for patients less than 18 years of age who were diagnosed with ACC between 1998 and 2011.
Lindsay J Talbot, Henry E Rice, Kristy L Rialon   +2 more
exaly   +5 more sources

Virilizing adrenocortical carcinoma in a child: A rare enigma

Indian Journal of Endocrinology and Metabolism, 2012
Adrenocortical carcinomas are rare tumors with an incidence of one to two cases per million population and are still more rarer in the pediatric age group.
Varuna Sipayya, Yogesh K Yadav, Rashmi Arora, Uma Sharma, Kusum Gupta   +4 more
doaj   +2 more sources

Pediatric Mixed Functioning Adrenocortical Carcinoma: A Case Report and Review of Literature [PDF]

Middle East Journal of Cancer, 2019
Adrenocortical carcinoma (ACC) is a very rare disease in the pediatric age group. The clinic-biological profile, histopathological criteria of diagnosis, and staging of this disease in this age group are different from those of adult ACC.
Sanjay Yadav, Chandan Jha, Saroj Mishra, Ritu Verma, Abhishek Krishna   +4 more
doaj   +2 more sources

International Delphi-based consensus: therapeutic approaches for pediatric adrenocortical carcinoma

European Journal of Endocrinology
Abstract Adrenocortical carcinoma (ACC) in children is a rare and aggressive malignancy. Despite representing a small fraction of pediatric adrenal tumors, ACC poses distinct challenges due to its heterogeneous biological behavior, frequent hormone secretion, and the limited availability of standardized, pediatric-specific treatment ...
Fragoso Maria, Van de Ven Kees, Riedmeier Maria, Abib Simone, Agarwal Shipra, Antoniazzi Augusto Perazollo, Antonini Sonir, G Suren Arul, Baecklund Fredrik, Brandalise Silvia, Daiggi Camila Maria Martin, Deal Cheri, Del Rivero Jaydira, Denes Francisco Tibor, Dumic Katja, Ekinci Saniye, El Jaick Tatiana, Engstler Gernot, Fassnacht Martin, Figueiredo Bonald Cavalcante, Flores Paula, Fortunati Daniela, Galuzzo Laura, Gönç Nazlı, Górecki Wojciech, Guercio Gabriela, Gültekin Melis, Guran Tulay, Haak Harm, Hendriks Emilie, Idkowiak Jan, Janus Dominika, Kremer Vilani, Krueger Johanna, G Lam Catherine, Luiz Fernando Lopes, Malkin David, Manousaki Despoina, Mattone Maria Celeste, Marks Stephen, Molina Carlos, Munarin Jessica, Ohmoto Akihiro, Pamporaki Christina, Pianovski Mara, Piché Nelson, Perier Nancy, Ribeiro Raul, Ribeiro Rodrigo Chaves, Rodrigues Karla, Taczanowska-Niemczuk Anna, D R Thompson Lester, Tuli Gerdi, Van Noesel Max, Calogero Virgone, G Waguespack Steven, Walz Martin, Wasserman Jonathan, Wiegering Armin, Yalcin Bilgehan, de Krijger Ronald R, Wiegering Verena   +61 more
openaire   +3 more sources

Adrenocortical carcinoma: Report of two cases

Indian Journal of Endocrinology and Metabolism, 2011
Adrenocortical carcinoma (ACC) is a rare neoplasm with a slight predilection for female patients. We report two cases of ACC. The first case was of a 7-year-old girl who presented with clitoromegaly.
C Aparna, I V Renuka, Saila G Bala, P Annapurna   +3 more
doaj   +2 more sources

Functional and behavioral outcomes in pediatric adrenal carcinoma under mitotane therapy: a caregiver-reported pilot study [PDF]

Endocrine Oncology
Objective: Mitotane is the standard therapy for advanced pediatric adrenocortical carcinoma (pACC). With improving survival, treatment-related long-term side effects and their impact on everyday functioning are becoming increasingly relevant.
Heidi Frey, Maria Riedmeier, Johanna Krüger, Carl Friedrich Classen, Nerea Domínguez-Pinilla, Maria Fragoso, Steffen Fuchs, Dominika Janus, Mouna Mezoued, Andrea Mocna, Jessica Munarin, Soraya Puglisi, Hilal Susam Sen, Gerdi Tuli, Justyna Walenciak, Bilgehan Yalcin, Martin Fassnacht, Verena Wiegering   +17 more
doaj   +2 more sources

Network analysis reveals potential markers for pediatric adrenocortical carcinoma. [PDF]

Onco Targets Ther, 2016
Pediatric adrenocortical carcinoma (ACC) is a rare malignancy with a poor outcome. Molecular mechanisms of pediatric ACC oncogenesis and advancement are not well understood. Accurate and timely diagnosis of the disease requires identification of new markers for pediatric ACC.
Kulshrestha A, Suman S, Ranjan R.
europepmc   +5 more sources

Adrenocortical carcinoma in a pediatric patient with li-fraumeni-like Syndrome: an endemic condition in southern Brazil [PDF]

Clinical and Biomedical Research, 2021
A 12-year-old boy with germline TP53-R337H mutation and family history of early adrenocortical carcinoma (ACC) was admitted to hospital with abdominal pain and distention.
Mariana Mendes Knabben, Renan Reis Caldas, Jéssica Onofre de Brito Lima, Aline Spader Casagrande, Caroline Lorenzoni Almeida Ghezzi   +4 more
doaj   +4 more sources