Results 101 to 110 of about 23,786 (267)

Diagnosis and treatment of growth hormone deficiency in childhood and adolescence: Consensus guidelines from the national pediatric endocrinology association in Turkey (Part 2) treatment of growth hormone deficiency [PDF]

, 2006
Büyüme hormonu eksikliğinde büyüme hormonu (BH) tedavisi ile nihai boyun normal sınırlar içine geldiği çeşitli çalışmalarda gösterilmiştir. Ancak, büyüme hormonu tedavisinin etkin olabilmesi için çeşitli faktörlerin (BH dozu, başlama yaşı, verilme ...
Şükran Darcan, Feyza Darendeliler
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Monoallelic POLR3A Variants Cause Early‐Onset Peripheral Neuropathy

Annals of Neurology, EarlyView.
Objective Biallelic variants in genes encoding the RNA polymerase III complex (Pol III) cause a spectrum of neurological disorders primarily affecting the central nervous system. Monoallelic variants have been reported in the POLR3B subunit only, associated with neurodevelopmental disorder, epilepsy, and peripheral neuropathy.
Luiza L. P. Ramos, Jevin M. Parmar, Robin Wijngaard, Bianca R. Grosz, Tamas Lazar, Ligia Mateiu, Steve Vucic, Kishore R. Kumar, Dennis Yeow, Laura I. Rudaks, Lonneke de Boer, Annemarie de Vreugd, David A. Koolen, Thatjana Gardeitchik, Anita Cairns, Krishnan Iyengar, Fernando Kok, Fernanda Barbosa Figueiredo, Alzira Alves de Siqueira Carvalho, Luiz S. Mageste Barbosa, Rodrigo Rezende Arantes, Tyler Rehbein, Jordan E. Bontrager, Elizabeth P. Wood, Janet E. Sowden, Gavin Monahan, Meutia Kumaheri, Ivy Cuijt, Melina Ellis, Gonzalo Perez‐Siles, Elyshia McNamara, Ronald van Beek, Celine B. Meijers, Ivaylo Tournev, Stephan Zuchner, Shoshana J. Wodak, Clara D. M. van Karnebeek, Nigel Laing, Liana N. Semcesen, David A. Stroud, David N. Herrmann, Velina Guergueltcheva, Marina L. Kennerson, Machteld M. Oud, Gianina Ravenscroft, Ayse Candayan, Albena Jordanova   +46 more
wiley   +1 more source

Managing Transition in Patients Treated with Growth Hormone

Frontiers in Endocrinology, 2017
Growth hormone (GH) promotes growth in children, but is also essential for bone strength, body composition, metabolic factors, such as lipid profile, and maintenance of quality of life. The Merck KGaA (Germany) funded “360° GH in Europe” meeting, held in
Berthold P. Hauffa, Philippe Touraine, Tanya Urquhart-Kelly, Ekaterina Koledova   +3 more
doaj   +1 more source

Alterações neurorradiológicas em pacientes com deficiência de hormônio de crescimento. [PDF]

, 2005
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Sá, Naiana Bittencourt de
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Growth Hormone Deficiency In A Child With Neurofibromatosis-Noonan Syndrome [PDF]

, 2016
Neurofibromatosis-Noonan syndrome (NFNS) is a distinct entity which shows the features of both NF1 (neurofibromatosis 1) and Noonan syndrome (NS). While growth hormone deficiency (GHD) has been relatively frequently identified in NF1 and NS patients ...
VIDAUD, D, Alikaşifoğlu, Ayfer, Vidaud, Dominique, Gönç, N, VURALLı, D, Özön, Alev, Kandemir, Nurgün, Vurallı, Doğuş, Gönç, Nazlı, OZON, A   +9 more
core   +1 more source

Prevalence of Hypothalamic–Pituitary Abnormalities in Pediatric Patients with Growth Hormone Deficiency

Sage Open Pediatrics
Growth hormone deficiency (GHD) is a key differential diagnosis in children with proportionate short stature. While brain magnetic resonance imaging (MRI) is recommended for all confirmed GHD cases to rule out hypothalamic-pituitary anomalies, its universal application remains debated We conducted a retrospective, single-center ...
Giorgio Sodero, Luigi Antonio Moscogiuri, Marilea Lezzi, Fabio Comes, Paola Passoforte, Giacomo Perrone, Aniello Meoli, Anna Camporeale, Antonietta Villirillo, Francesco Gallo   +9 more
openaire   +2 more sources

Gut–Brain Axis Modulation by Short‐Chain Fatty Acids Exerts Disease‐Modifying Effects in a Murine Model of Drug‐Resistant Epilepsy

Annals of Neurology, EarlyView.
Objective Drug‐resistant epilepsy (DRE) remains a clinical challenge, as therapies modifying disease trajectory are lacking. Increasing evidence implicates gut microbiota dysbiosis in epilepsy pathophysiology, with short‐chain fatty acids (SCFAs) emerging as key microbial metabolites with neuroprotective and anti‐inflammatory properties.
Akash A. Bera, Rossella Di Sapia, Greta Volpedo, Sneha Anand, Eray Sahin, Pasquale Baldassarre, Francesca Buffelli, Andrea Petretto, Chiara Lavarello, James D. Mills, Gabriele Cattaneo, Ilaria Craparotta, Eleonora Aronica, Antonella Riva, Pasquale Striano, Annamaria Vezzani, Teresa Ravizza   +16 more
wiley   +1 more source

Design Considerations for Polymer–Deep Eutectic Solvent Hybrid Systems for Transdermal Drug Delivery

Journal of Applied Polymer Science, EarlyView.
Deep eutectic solvents (DESs) act as tunable, green excipients that modulate polymer structure–property relationships to enhance drug solubility, skin permeation, stability, and controlled release. Through hydrogen‐bond interactions, DES–polymer hybrid systems enable improved transdermal performance, offering a rational, design‐driven platform for ...
Madhavi Kailas Kapale, Madhur Kulkarni, Pranav J. Shah, Furqan A. Maulvi   +3 more
wiley   +1 more source

Ethical Issues in Growth Hormone Therapy [PDF]

, 1989
Growth hormone therapy for short children who do not meet the classic criteria for growth hormone deficiency should be evaluated from the perspective of cultural values, not biologic norms of health. Physicians can weigh the ethical acceptability of new
Siegler, Mark, Cuttler, Leona, Lantos, John   +2 more
core   +1 more source

Positive influence of long-term growth hormone therapy on circulating stem cells in pediatric patients with growth hormone deficiency

Scientific Reports
Very small embryonic/epiblast‐like stem cells (VSELs), present in circulating blood, are small, non-hematopoietic cells that express markers of pluripotent embryonic and primordial germ cells.
Anna Wędrychowicz, Katarzyna Sielatycka,, Magda Kucia, Ewa Kubiś, Dorota Roztoczyńska, Jerzy B. Starzyk   +5 more
doaj   +1 more source