Results 131 to 140 of about 6,542,588 (257)

Retinal Nerve Fiber Layer Thickness in Children With Isolated Growth Hormone Deficiency

Isolated growth hormone deficiency (iGHD) is a condition causing severe short stature due to a lack of growth hormone (GH). GH\u27s impact on the eye, particularly retinal nerve fiber layer (RNFL), is unclear.
Gulcenur Ozturan; Digdem Bezen; Gulderen Karaca; Dogancan Ozturan; Mustafa Nuri Elcioglu
core  

Growth hormone and ageing

, 2000
The proportion of elderly people is steadily growing in Western societies. The result is a disproportionate accumulation of the oldest and most vulnerable sector of the population, suffering from frailty-associated disorders and cardiovascular diseases ...
Bengtsson, B A, Svensson, J, Johannsson, Gudmundur,   +2 more
core  

Transcriptomic analysis reveals distinct expression patterns in focal cortical dysplasia

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a common cause of drug‐resistant epilepsy in children and adults and exhibits substantial clinical and histopathological heterogeneity. However, morphological classification alone does not fully explain variability in epileptogenicity, disease severity, or treatment response.
Shivani Sonawane, Michal Hendrych, Michaela Ručková, Robin Jugas, Jan Vrbský, Martin Pail, Barbora Straka, Martina Strnadová, Lenka Krsková, Adam Vácha, Miroslav Koblížek, Barbora Splítková, Kateřina Koželková, Eliška Hloušková, Tereza Vaňková, Josef Zámečník, Štefánia Aulická, Markéta Hermanová, Pavel Kršek, Ondřej Slabý, Milan Brázdil   +20 more
wiley   +1 more source

Patient-Centric Design of the Lonapegsomatropin Auto-Injector for Growth Hormone Deficiency: Usability Validation of Safe and Effective Use

Medical Devices: Evidence and Research
Michael Lau,1 Paul Erik Fabricius,2 Nils Berg Madsen,3 Henrik Egesborg,3 Josephine Jensen3 1Human Factors Engineering, Insight by Nemera, Chicago, IL, USA; 2Industrial Design and HFE, Phillips-Medisize A/S, Struer, Denmark; 3Device Development, Ascendis ...
Lau M, Fabricius PE, Madsen NB, Egesborg H, Jensen J   +4 more
doaj  

Diagnosis and treatment of growth hormone deficiency in childhood and adolescence: Consensus guidelines from the national pediatric endocrinology association in Turkey (Part 2) treatment of growth hormone deficiency

, 2006
Büyüme hormonu eksikliğinde büyüme hormonu (BH) tedavisi ile nihai boyun normal sınırlar içine geldiği çeşitli çalışmalarda gösterilmiştir. Ancak, büyüme hormonu tedavisinin etkin olabilmesi için çeşitli faktörlerin (BH dozu, başlama yaşı, verilme ...
Şükran Darcan, Feyza Darendeliler
core  

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches

Epilepsia Open, EarlyView.
Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza, Greta Volpedo, Antonella Riva, Pasquale Striano, Annamaria Vezzani   +4 more
wiley   +1 more source

Growth hormone deficiency

, 2010
Growth hormone deficiency is the most promising entity in terms of response to therapy among the treatable causes of growth retardation. It may be due to genetic or acquired causes.
Sağlam, Halil, Tarım, Ömer
core  

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source