Results 131 to 140 of about 1,105,809 (304)

A Generalizable Multimodal Model for Treatment‐Stratified Risk and Survival Assessment under Real‐World Constraints: A Multi‐Center Study of Colorectal Cancer

Advanced Science, EarlyView.
DAIMS is a multimodal model for treatment stratified risk and survival assessment in colorectal cancer. Training draws on pathology, genomics, and clinical reports, yet inference requires only whole slide images, and adaptation to new cohorts proceeds without target survival outcomes.
Chuangjie Cao, Zheyi Ji, Chang He, Jiying Wang, Xiaoming Luo, Junyi Liu, Xiaohu Jing, Fang Yan, Yirong Chen, Linhao Qu, Sen Yang, Le Lu, Yuming Jiang, Xiyue Wang, Chengyun Dou, Junhan Zhao   +15 more
wiley   +1 more source

A Living Multi‐Omics PDX Biobank of High‐Risk Sarcomas Reveals ecDNA‐Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology

Advanced Science, EarlyView.
A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao, Zhiwei Cheng, Kai Tian, Mengxiong Sun, Zhuoying Wang, Ming Jiao, Jens Luebeck, Kaiyuan Zhu, Xiao Zhang, Dongqing Zuo, Hongsheng Wang, Chongren Wang, Jiakang Shen, Xiaojun Ma, Gangyang Wang, Zongyi Wang, Jing Han, Kaiyuan Liu, Haoran Mu, Weiqi Ma, Yongyong Ren, Shibing Guo, Huangxin Tu, Lingfeng Yu, Yining Tao, Yu Lv, Hui Lu, Owen S. Chapman, Rishaan Kenkre, Lukas Chavez, Zhengdong Cai, Yuqin Yang, Wei Sun, Yafei Jiang, Yingqi Hua   +34 more
wiley   +1 more source

BRCA1 Mutation‐Recognizing Tetrahedral Framework Nucleic Acid Nanoplatform Enables Coordinated PARP/WEE1 Inhibition and STING‐Associated Antitumor Immunity in Ovarian Cancer

Advanced Science, EarlyView.
BRCA1 mutation‐responsive FBOA‐tFNA selectively recognizes mutant transcripts and coordinates reduction‐responsive intracellular delivery of olaparib and adavosertib, amplifying DNA damage and weakening G2/M checkpoint protection. These effects are accompanied by STING‐associated immune activation and stronger antitumor immunity, while sequential anti ...
Chenyi Wang, Mengying Yao, Jinhui Xie, Dingjie Wang, Yashi Shi, Xiaodan Mao, Chunhua Lu, Pengming Sun   +7 more
wiley   +1 more source

Clinical Characteristics and Outcomes of Pediatric Oncology Patients Admitted to the Pediatric Intensive Care Unit: A Single Center Experience in Saudi Arabia

Children
Background/Objectives: Advances in pediatric oncology have improved survival; however, critically ill children with cancer remain at high risk for adverse outcomes and frequently require admission to the pediatric intensive care unit (PICU).
Wafaa Aljizani, Fatmah Othman, Faisal Alrashed, Faisal Althaqeel, Obaid Alfuraydi   +4 more
doaj   +1 more source

Sensitivity analysis population (2): pediatric oncology patients.

, 2016
Sensitivity analysis population (2): pediatric oncology patients.
Michiel F. Schreuder (3394550), Manuela A. Joore (3394556), Roger J. M. Brüggemann (3394553), Stefanie S. Henriet (3394562), Rob E. Aarnoutse (3394559), Lisa C. Martial (3394547)   +5 more
core   +1 more source

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

Annals of Gastroenterological Surgery, EarlyView.
This multicenter prospective study provides the first Japanese evidence that circumferential resection margin positivity after minimally invasive surgery is associated with poorer long‐term outcomes in locally advanced rectal cancer. As the cohort predominantly included patients treated with upfront surgery, these findings provide important evidence to
Atsushi Hamabe, Masaaki Ito, Shigeo Toda, Yusuke Suwa, Suguru Hasegawa, Masanori Kotake, Masafumi Inomata, Kazuki Ueda, Atsushi Ogura, Kiichi Sugimoto, Kei Kimura, Koki Otsuka, Tatsuki Noguchi, Koya Hida, Yasumitsu Hirano, Kazushige Kawai, Shigeru Yamagishi, Takeshi Naitoh, Ichiro Takemasa, on behalf of Japan Society of Laparoscopic Colorectal Surgery   +19 more
wiley   +1 more source

Bevacizumab in Pediatric Neuro-Oncology [PDF]

Bevacizumab is often used off-label in pediatric neuro-oncology, and evidence for indications of bevacizumab use in pediatric neuro-oncology is often fragmented.
Jacob Silverman, Sayanthen Sathyakumar, Eric Bouffet, Bouffet, Eric, Samuele Renzi, Sathyakumar, Sayanthen, Perreault, Sebastien, Silverman, Jacob, Renzi, Samuele, Nada Jabado, Coltin, Hallie, Jabado, Nada, Hallie Coltin, Sebastien Perreault   +13 more
core   +1 more source

Essential Updates in the Surgical Management of Inflammatory Bowel Disease: Current Topics From 2024 to Mid‐2026

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Inflammatory bowel disease management has undergone a major transformation with the introduction of treat‐to‐target strategies and highly effective biologic and small‐molecule therapies. Although these advances have reduced the overall requirement for surgery, operative intervention remains essential for selected patients with ulcerative ...
Yoshiki Okita, Tadanobu Shimura, Mikio Kawamura, Yuhki Koike, Yuji Toiyama   +4 more
wiley   +1 more source

Hypertriglyceridemia During Anticancer Therapy in Pediatric Patients with Acute Lymphoblastic Leukemia – A Nationwide Experience

Cancer Management and Research
Joanna Zawitkowska,1,2 Eryk Latoch,3,4 Katarzyna Karska,1 Katarzyna Drabko,1 Monika Lejman,5 Klaudia Ewelina Paczóska,6 Tomasz Ociepa,6 Anna Malecka,7 Dorota Sęga-Pondel,8 Krzysztof Kalwak,8 Katarzyna Konończuk,3 Julia Ko&lstrok ...
Zawitkowska J, Latoch E, Karska K, Drabko K, Lejman M, Paczóska KE, Ociepa T, Malecka A, Sęga-Pondel D, Kalwak K, Konończuk K, Kołodrubiec J, Trelińska J, Demidowicz E, Andrzejewska M, Derwich K, Zakrzewska Z, Skoczeń S, Mizia-Malarz A, Karolczyk G, Bal W, Chaber R, Tyszka P, Badowska W, Janiszewska M, Kowalczyk J, Młynarski W, Szczepański T, Styczyński J, Irga-Jaworska N, Muszyńska-Rosłan K   +30 more
doaj  

Workplace Harassment and Consideration of Leaving Surgical Practice: A Nationwide Survey by the Japanese Society of Gastroenterological Surgery

Annals of Gastroenterological Surgery, EarlyView.
In this nationwide survey of 1967 members of the Japanese Society of Gastroenterological Surgery, 66% reported experiencing workplace harassment, and 56% of those affected had considered leaving surgical practice. These findings highlight the need for sustained, society‐wide efforts to prevent harassment and foster respectful and psychologically safe ...
Keisuke Kurimoto, Tsutomu Fujii, Yoshihiro Shirai, Atsuro Fujinaga, Masayuki Fukumoto, Sonoko Ishida, Koya Hida, Chie Tanaka, Tsunekazu Mizushima, Sachiyo Nomura, Ken Shirabe   +10 more
wiley   +1 more source