Results 1 to 10 of about 4,157,414 (204)

Childhood and adolescent cancer in Germany – an overview [PDF]

Journal of Health Monitoring, 2023
Background: Childhood and adolescent cancer constitutes only a very small fraction of the cancer cases in Germany and throughout the world, but it is the most frequent cause of disease-related death in children.
Claudia Spix, Friederike Erdmann, Desiree Grabow, Cécile Ronckers   +3 more
doaj   +1 more source

Employment, occupation, and income in adults with neurofibromatosis 1 in Denmark: a population- and register-based cohort study

Orphanet Journal of Rare Diseases, 2023
Background Little is known about employment status, occupation, and disposable income in adults with NF1. Methods From the Danish National Patient Registry and database of two national Centers for Rare Diseases, we identified 1469 adults with NF1, who ...
Line Kenborg, Line E. Frederiksen, Michael Galanakis, Karoline Doser, Thomas T. Nielsen, Mia Aagaard Doherty, Hanne Hove, John R. Østergaard, Mette M. Handrup, Cecilie Ejerskov, John J. Mulvihill, Jeanette F. Winther   +11 more
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Targeting WEE1 kinase as a p53-independent therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia

Cancer Cell International, 2023
Background Outcomes for patients with relapsed acute lymphoblastic leukemia (ALL) are poor and there is a need for novel therapies to improve outcomes.
Hayden L. Bell, Helen J. Blair, Mankaran Singh, Anthony V. Moorman, Olaf Heidenreich, Frederik W. van Delft, John Lunec, Julie A. E. Irving   +7 more
doaj   +1 more source

Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia

Haematologica, 2020
T-cell Acute Lymphoblastic Leukemia (T-ALL) is frequently characterized by glucocorticoid (GC) resistance, which is associated with inferior outcomes, thus highlighting the need for novel therapeutic approaches for GC resistant T-ALL.
Yuzhe Shi, Melanie C. Beckett, Helen J. Blair, Ricky Tirtakusuma, Sirintra Nakjang, Amir Enshaei, Christina Halsey, Josef Vormoor, Olaf Heidenreich, Anja Krippner-Heidenreich, Frederik W. van Delft   +10 more
doaj   +1 more source

scATAC-pro: a comprehensive workbench for single-cell chromatin accessibility sequencing data

Genome Biology, 2020
Single-cell chromatin accessibility sequencing has become a powerful technology for understanding epigenetic heterogeneity of complex tissues. However, there is a lack of open-source software for comprehensive processing, analysis, and visualization of ...
Wenbao Yu, Yasin Uzun, Qin Zhu, Changya Chen, Kai Tan   +4 more
doaj   +1 more source

Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21

Haematologica, 2018
Intrachromosomal amplification of chromosome 21 is a heterogeneous chromosomal rearrangement occurring in 2% of cases of childhood precursor B-cell acute lymphoblastic leukemia.
Paul. B. Sinclair, Helen H. Blair, Sarra L. Ryan, Lars Buechler, Joanna Cheng, Jake Clayton, Rebecca Hanna, Shaun Hollern, Zoe Hawking, Matthew Bashton, Claire J. Schwab, Lisa Jones, Lisa J. Russell, Helen Marr, Peter Carey, Christina Halsey, Olaf Heidenreich, Anthony V. Moorman, Christine J. Harrison   +18 more
doaj   +1 more source

Equivalent doses for anticancer agents used in pediatric oncology: A literature review and evaluation of a novel approach for conversion factors

Cancer Reports, 2023
Background Epidemiological research on late effects of therapy shows the necessity to aggregate chemotherapy agents to substance classes. This requires using conversion factors by substance classes.
Meike Ressing, Cornelia Becker, Christian Müller, Seyed Hamidreza Mahmoudpour, Gabriele Calaminus, Thorsten Langer, Friederike Erdmann, Mathias Voigt, Melanie Kaiser, Peter Kaatsch, Maria Blettner, Claudia Spix   +11 more
doaj   +1 more source

Income disparities between adult childhood cancer survivors and their peers—A register‐based cohort study from the SALiCCS research programme

Cancer Medicine, 2023
Background Childhood cancer survivors face various adverse consequences. This Nordic register‐based cohort study aimed to assess whether survivors of childhood cancer are more likely to have low income than their peers.
Anniina Kyrönlahti, Friederike Erdmann, Maria Feychting, Line Elmerdahl Frederiksen, Elli Hirvonen, Liisa Maria Korhonen, Anja Krøyer, Luzius Mader, Nea Malila, Hanna Mogensen, Camilla Pedersen, Mats Talbäck, Mervi Taskinen, Jeanette Falck Winther, Laura Madanat‐Harjuoja, Janne Pitkäniemi   +15 more
doaj   +1 more source

Stress-Induced Isoforms of MDM2 and MDM4 Correlate with High-Grade Disease and an Altered Splicing Network in Pediatric Rhabdomyosarcoma

Neoplasia: An International Journal for Oncology Research, 2013
Pediatric rhabdomyosarcoma (RMS) is a morphologically and genetically heterogeneous malignancy commonly classified into three histologic subtypes, namely, alveolar, embryonal, and anaplastic.
Aishwarya G. Jacob, Dennis O'Brien, Ravi K. Singh, Daniel F. Comiskey, Jr, Robert M. Littleton, Fuad Mohammad, Jordan T. Gladman, Maria C. Widmann, Selvi C. Jeyaraj, Cheryl Bolinger, James R. Anderson, Donald A. Barkauskas, Kathleen Boris-Lawrie, Dawn S. Chandler   +13 more
doaj   +1 more source

Circulating tumor DNA reveals mechanisms of lorlatinib resistance in patients with relapsed/refractory ALK-driven neuroblastoma

Nature Communications, 2023
Activating point mutations in Anaplastic Lymphoma Kinase (ALK) have positioned ALK as the only mutated oncogene tractable for targeted therapy in neuroblastoma.
Esther R. Berko, Gabriela M. Witek, Smita Matkar, Zaritza O. Petrova, Megan A. Wu, Courtney M. Smith, Alex Daniels, Joshua Kalna, Annie Kennedy, Ivan Gostuski, Colleen Casey, Kateryna Krytska, Mark Gerelus, Dean Pavlick, Susan Ghazarian, Julie R. Park, Araz Marachelian, John M. Maris, Kelly C. Goldsmith, Ravi Radhakrishnan, Mark A. Lemmon, Yaël P. Mossé   +21 more
doaj   +1 more source