Results 111 to 120 of about 996,187 (255)

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Familial pediatric endocrine tumors.

, 2011
Learning Objectives After completing this course, the reader will be able to: Explain the contribution of genetics to heritable aspects of pediatric cancer.Describe the applications of presymptomatic gene testing in family members with ...
Morrison, Patrick, Patrick J. Morrison, Deirdre E. Donnelly, Dennis Carson, Lisa Bradley, Sarinda Millar   +5 more
core   +2 more sources

Recent advances in the study of reproductive function in pediatric patients with brain tumors

Frontiers in Pediatrics
In recent years, pediatric brain tumors have emerged as one of the most common malignant tumors among children. The site of tumor growth and the selected treatment modalities can potentially have a profound and significant impact on the reproductive ...
Rui Zhang, Linlin Liu, Xinyu Dai, Yan Ju, Yanming Ren   +4 more
doaj   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

Malignant pancreatic tumors: incidence and outcome in 58 pediatric patients

, 2009
The purpose of the study was to examine current incidence trends and outcomes for children with pancreatic malignancies. The Surveillance, Epidemiology, and End Results registry (1973-2004) was examined for pediatric patients with pancreatic malignancies
Gutierrez, Juan C, Thompson, William R, Perez, Eduardo A, Sola, Juan E, Koniaris, Leonidas G, Neville, Holly L   +5 more
core   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Meta-analysis of mortality factors after COVID-19 infection in pediatric oncology patients

Frontiers in Oncology
ObjectiveThere are few clinical studies related to COVID-19 in pediatric cancer patients, and systematic reviews or meta-analyses on its mortality risk factors are particularly lacking. Therefore, we conducted this meta-analysis to systematically analyze
Qingchen Liu, Qingchen Liu, Xia Wang, Xia Wang, Xueqin Zhou, Xueqin Zhou   +5 more
doaj   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

U.S. Pediatric Dentists’ Perception of Molar Incisor Hypomineralization

, 2018
Purpose: The purpose of this survey-based study was to target U.S. pediatric dentists in the Midwest region to determine their knowledge, perceptions, and clinical management strategies of molar incisor hypomineralization (MIH).
Eckert, George J., Dean, Jeffrey A., Martinez Mier, Esperanza A., Tagelsir, Azza   +3 more
core   +1 more source

Extracellular vesicles derived from bone marrow mesenchymal stem cells regulate SREBF2/HMGB1 axis by transporting miR-378a-3p to inhibit ferroptosis in intestinal ischemia-reperfusion injury

Cell Death Discovery
Intestinal ischemia-reperfusion (II/R) injury represents a life-threatening and complex pathophysiological process that remains challenging to treat clinically, and emerging evidence suggests that ferroptosis plays an essential role in its pathogenesis ...
Zan Liu, Zitong Zhao, Zhenghui Xiao, Ming Li, Xiyang Wang, Yan Huang, Yong Li   +6 more
doaj   +1 more source