Results 81 to 90 of about 1,264,266 (345)
Detection of KIT mutations in core binding factor acute myeloid leukemia
Leukemia Research Reports, 2018 We have investigated the frequency and the effect of KIT mutations on the outcome of patients with CBF-AML. 69 patients (34 pediatrics and 35 adults) with CBF-AML were enrolled in the study. The frequency of KIT mutations was higher in adults compared to
Passant Badr +4 more
doaj +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Journal of Inflammation ResearchZhilin Liu, Yonghong Jiang, Qiuyue Fan, Sai Li, Yanni Wang Department of Paediatrics, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, People’s Republic of ChinaCorrespondence: Yonghong Jiang, Email ...
Liu Z, Jiang Y, Fan Q, Li S, Wang Y
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Respiratory tract infections in pediatrics: difficult answers to simple questions
, 2020 Irina V. Andreeva +2 more
openalex +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
From Simulation to Bedside: the Missing Link in Pediatric Training Research [Response to Letter]
Advances in Medical Education and PracticeHongjun Ba, Lingling Xu, Huimin Peng, Yufen Gu, Yijuan Li, Xiaoyun Jiang, Xiaoyu Li, Shujuan Li Pediatric Department, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, People’s Republic of ChinaCorrespondence: Xiaoyu ...
Ba H +7 more
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Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Barcelona Respiratory Network ReviewsBronchiectasis in children is a long-term respiratory condition defined by a persistent productive cough, airway infection, and inflammation, with visible bronchial dilatation on chest computed tomography.
Laura Garriga-Grimau +2 more
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