Results 51 to 60 of about 76,180 (261)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Coenzyme Q10 supplementation enhances HSP70 gene expression and preserves mitochondrial function in cryopreserved Peranakan Ettawa goat spermatozoa [PDF]

Veterinary World
Background and Aim: Inbreeding is a major concern in livestock breeding because it can reduce genetic diversity, impair fitness, and compromise long-term population sustainability.
Yudit Oktanella, Imam Mustofa, Suherni Susilowati, Widjiati Widjiati, Tri Wahyu Suprayogi, Yayuk Kholifah   +5 more
doaj   +1 more source

Inheritance of Hypertrichosis Pinnae Auris-A Review of Literature [PDF]

Journal of Clinical and Diagnostic Research, 2018
Hypertrichosis is an excessive growth of hair on a particular area of the body which is abnormal for the age, sex or race of an individual. The presence of the excessive coarse black hair on the auricle of the human ear is referred to as hypertrichosis ...
Neha Baryah, Kewal Krishan, Sanjeev Puri, Tanuj Kanchan   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

POPULATION GENETIC STRUCTURE OF AUTOCHTHONOUS BLACK SLAVONIAN PIG [PDF]

Poljoprivreda, 2015
As Black Slavonian pig was forgotten and replaced by commercial hybrid pigs, after mid 1950s population declined drastically. Today’s population was founded from 46 sows and 6 boars in 1996 while currently consist of 1064 sows and 163 boars.
Boris Lukić, Anamarija Smetko, Željko Mahnet, Vedran Klišanić, Marija Špehar, Nikola Raguž, Goran Kušec   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Mitochondrial DNA Survey Reveals the Lack of Accuracy in Maremmano Horse Studbook Records

Animals, 2020
The Maremmano horse is considered one of the most important Italian warmblood breeds which originated from an ancient population. In 1980, the National Association of Maremmano Breeders established the first Studbook that recorded 440 dams and four sire ...
Andrea Giontella, Irene Cardinali, Hovirag Lancioni, Samira Giovannini, Camillo Pieramati, Maurizio Silvestrelli, Francesca Maria Sarti   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Demographic approach on the study of genetic parameters in the dog Braque Français type Pyrénées Italian population

Italian Journal of Animal Science, 2016
The complete electronic record of the Braque Français type Pyrénées reared in Italy was downloaded from the ENCI database in order to estimate the genetic variability of the breed. Pedigree records of all active registered animals (reference population = 
Francesca Cecchi, Gisella Paci, Andrea Spaterna, Marco Ragatzu, Roberta Ciampolini   +4 more
doaj   +1 more source