Results 71 to 80 of about 76,180 (261)
World Rabbit Science, 2018 The genetic structure of a small population of New Zealand White rabbits maintained at the Sheep Breeding and Research Station, Sandynallah, The Nilgiris, India, was evaluated through pedigree analyses.
M. Sakthivel +6 more
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Pedigree analysis in the SIKA rabbits in Slovenia
Acta agriculturae Slovenica. Suplement, 2012 The aim of the study was to determine the current level of inbreeding of SIKA rabbits in Slovenia. The pedigree of 27.110 rabbits was analysed. There were 13.521 males and 13.589 females. Without known parents were 146 animals. Altogether, there were 1490 dams and 391 sires. For a reference population we used animals born in years 2010 and 2011.
Kermauner, Ajda +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Evolutionary ApplicationsThe establishment and spread of invasive species are directly related to intersexual interactions as dispersal and reproductive success are related to distribution, effective population size, and population growth. Accordingly, populations established by
Nicole E. Adams +6 more
doaj +1 more source
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2007 Foram preditas diferenças esperadas na progênie para probabilidade de permanência no rebanho (stayability) de 4180 touros com filhas na base de dados do Programa de Melhoramento Genético da Raça Nelore, utilizando-se modelo de limiar unicaráter de touro ...
C.R. Marcondes +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Improving strawberry fruit quality through breeding: cultivar performance and biochemical diversity
Notulae Botanicae Horti Agrobotanici Cluj-NapocaStrawberry (Fragaria × ananassa Duch.) breeding has a long tradition worldwide, driven by the need to combine high yields with superior fruit quality and resilience to environmental challenges.
Monica STURZEANU +3 more
doaj +1 more source