Results 51 to 60 of about 89,660 (267)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The exploration of attitudes and perspectives of mental health workers on peer support in Singapore

Discover Mental Health
Background Using the lived experience as their expertise, peer support specialists (PSS) focus on the empowerment of individuals with mental health conditions. Despite its value, peer support services in Singapore are relatively uncommon.
Siong Yin Chua, Karel Himawan
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Peer Support Specialist Services in Suicide Prevention

Crisis
Abstract: Peer support specialist services aimed at reducing suicide risk are becoming more prominent in professional roles in healthcare systems and community settings. Such services may directly or indirectly contribute to suicide prevention efforts.
Stephen S. O’Connor, Lisa H. Jaycox, Rebecca Kurikeshu, Brendan Weintraub, Joel Sherrill, Jane Pearson   +5 more
openaire   +1 more source

The Effects of State Regulations and Medicaid Plans on the Peer Support Specialist Workforce

Health Services Research, 2020
Peer support specialists have proven to be a cost‐effective and clinically effective workforce in improving patient quality of life and symptom management, while decreasing avoidable emergency room visits and care overutilization. This study used publicly available datasets to map and type locations where peer services are provided, and determine how ...
C. Page, L. Videka, J. Neale, J. Buche, R. Thomas, M. Gaiser, C. Wayment, A. Beck   +7 more
openaire   +2 more sources

Facilitating treatment engagement for early psychosis through peer-delivered decision support: intervention development and protocol for pilot evaluation

Pilot and Feasibility Studies, 2021
Background Emerging adults with early psychosis demonstrate high rates of service disengagement from critical early intervention services. Decision support interventions and peer support have both been shown to enhance service engagement but are ...
Elizabeth C. Thomas, John Suarez, Alicia Lucksted, Laura A. Siminoff, Irene Hurford, Lisa B. Dixon, Maria O’Connell, David L. Penn, Mark S. Salzer   +8 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A Refugee and Immigrant Peer Support Program in the United States

Intervention Journal of Mental Health and Psychosocial Support in Conflict Affected Areas
This field report describes the development and implementation of a curriculum for peer psychosocial support (PSS) for refugees and immigrants in the United States. From 2017 to 2019, we piloted an adapted PSS multistakeholder-approved peer curriculum to
Sasha Verbillis-Kolp, Kristen Guskovict, Mahad Hassan, Seth Cohen   +3 more
doaj   +1 more source