Results 51 to 60 of about 294,033 (277)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Physical and mental health of behavioural health certified peer specialists in four US states

BMJ Mental Health
Background Little is known about the health and healthcare needs of the behavioural health peer specialist workforce in the USA. This study explored the physical and mental health-related quality of life (QOL) of a US multistate cohort of certified peer ...
Judith A Cook, Jane K Burke-Miller, Morgan Pelot, Jessica A Jonikas, Laysha Ostrow   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Addressing Alcohol\u27s Role in Campus Sexual Assault: A Toolkit by and for Prevention Specialists [PDF]

, 2018
This toolkit provides specific guidance on addressing alcohol\u27s role in campus sexual assault, centering Sexual Assault Prevention Specialists as the intended ...
Helmken, Lee, Klein, L. B., Rizzo, Andrew J., Woofter, Rebecca C.   +3 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Psychosocial interventions for autistic children and adolescents delivered by non-specialists in low- and middle-income countries: a scoping review

Frontiers in Psychology, 2023
BackgroundMost autistic individuals reside in low- and middle-income countries (LMIC) and have limited access to medical providers and specialists. Support for delivery of psychosocial interventions by non-specialists is growing to address this mental ...
Megan Cherewick, Christina Daniel, Catherine Canavan Shrestha, Priscilla Giri, Choden Dukpa, Christina M. Cruz, Roshan P. Rai, Michael Matergia, Michael Matergia   +8 more
doaj   +1 more source

Becoming Adults: One-Year Impact Findings from the Youth Villages Transitional Living Evaluation [PDF]

, 2015
Young adults with histories of foster care or juvenile justice custody experience poor outcomes across a number of domains, on average, relative to their peers. While government funding for services targeting these groups of young people has increased in
Erin Jacobs Valentine, Mark E. Courtney, Melanie Skemer   +2 more
core  

GeoCoin:supporting ideation and collaborative design with location-based smart contracts [PDF]

, 2018
Design and HCI researchers are increasingly working with complex digital infrastructures, such as cryptocurrencies, distributed ledgers and smart contracts. These technologies will have a profound impact on digital systems and their audiences.
Mehrpouya, Hadi, Murray-Rust, Dave, Nissen, Bettina, Oosthuizen, Shaune, Pschetz, Larissa, Speed, Chris   +5 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

The Effects of State Regulations and Medicaid Plans on the Peer Support Specialist Workforce

Health Services Research, 2020
Peer support specialists have proven to be a cost‐effective and clinically effective workforce in improving patient quality of life and symptom management, while decreasing avoidable emergency room visits and care overutilization. This study used publicly available datasets to map and type locations where peer services are provided, and determine how ...
C. Page, L. Videka, J. Neale, J. Buche, R. Thomas, M. Gaiser, C. Wayment, A. Beck   +7 more
openaire   +2 more sources