Results 61 to 70 of about 294,033 (277)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The exploration of attitudes and perspectives of mental health workers on peer support in Singapore

Discover Mental Health
Background Using the lived experience as their expertise, peer support specialists (PSS) focus on the empowerment of individuals with mental health conditions. Despite its value, peer support services in Singapore are relatively uncommon.
Siong Yin Chua, Karel Himawan
doaj   +1 more source

Peer specialists and mental health nurses who work with patients who are suicidal: A comparative interview study

International Journal of Nursing Studies Advances
Background: In the field suicide prevention, knowledge about the involvement and approaches of peer specialists is scarce, prompting an examination of their potential unique contributions compared to what mental health nurses offer.
Diana D. Van Bergen, Tove Henseler
doaj   +1 more source

Promising Practices: Benefits Planning, Assistance and Outreach Services Provided by Centers for Independent Living [PDF]

, 2006
The Benefits Planning, Assistance and Outreach (BPA&O) program has been developed by SSA to provide accurate, current, individualized benefits and work incentives information to people with disabilities.
Malloy, JoAnne, Otto, Barbara
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Facilitating treatment engagement for early psychosis through peer-delivered decision support: intervention development and protocol for pilot evaluation

Pilot and Feasibility Studies, 2021
Background Emerging adults with early psychosis demonstrate high rates of service disengagement from critical early intervention services. Decision support interventions and peer support have both been shown to enhance service engagement but are ...
Elizabeth C. Thomas, John Suarez, Alicia Lucksted, Laura A. Siminoff, Irene Hurford, Lisa B. Dixon, Maria O’Connell, David L. Penn, Mark S. Salzer   +8 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Refugee and Immigrant Peer Support Program in the United States

Intervention Journal of Mental Health and Psychosocial Support in Conflict Affected Areas
This field report describes the development and implementation of a curriculum for peer psychosocial support (PSS) for refugees and immigrants in the United States. From 2017 to 2019, we piloted an adapted PSS multistakeholder-approved peer curriculum to
Sasha Verbillis-Kolp, Kristen Guskovict, Mahad Hassan, Seth Cohen   +3 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Learning from experience, for experienced staff [PDF]

, 2004
Business needs in multinational corporations call for courses that involve problem solving and creating and sharing new knowledge based on workplace situations. The courses also need to be engaging for the participants.
Collis, Betty, Nicholson, Gerry, Waring, Burney   +2 more
core   +2 more sources