Results 121 to 130 of about 63,196,727 (310)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
PEER D5.3 USAGE STUDY Randomised controlled trial results
, 2012 This report reviews the findings of an experiment to measure the effect of exposing early article versions in repositories on downloads of the version of record at various publishers' web sites. The research design used was a randomised controlled trial (
Rowlands, Ian +2 more
core +1 more source
, 2005 Peer-to-peer systems are gaining increasing popularity as a scalable means to share data among a large number of autonomous nodes. Since the shared data are unstructured and they do not follow a global schema, XML-based descriptions of the data can be used to provide a uniform way to query the heterogeneous data.
openaire +4 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Peer-to-Peer Overlay in Mobile Ad-hoc Networks
, 2009 Wireless multi-hop networks such as mobile ad-hoc (MANET) or wirelessmesh networks (WMN) have attracted big research efforts during the last yearsas they have huge potential in several areas such as military communications, fastinfrastructure replacement
Korpeoglu, Ibrahim +5 more
core
Towards a Canonical View of Peer Assessment
, 2007 Peer Assessment (or Peer Review) is a popular form of reciprocal assessment where students produce feedback, or grades, for each others work. Peer Assessment activities can be extremely varied with participants taking different roles at different stages ...
Sinclair, Patrick +13 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
New self-organized task scheduling topology structure in p2p computing——K+tree
Tongxin xuebao, 2005 A new self-organized task scheduling topology structure—K+ tree—was provided. A K+ tree was composed of a L-tier K-ary tree and a （L?1）-tier K-ary tree.
CHEN Hong-wei1, WANG Ru-chuan1
doaj