Results 41 to 50 of about 63,196,727 (310)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Jupiter: Peer-to-Peer Networking Platform over Heterogeneous Networks [PDF]
Journal of Systemics, Cybernetics and Informatics, 2006 Peer-to-peer has entered the public limelight over the last few years. Several research projects are underway on peer-to-peer technologies, but no definitive conclusion is currently available. Compared with traditional Internet technologies, peer-to-peer
Norihiro Ishikawa +4 more
doaj
Nodes in the Bitcoin Network: Comparative Measurement Study and Survey
IEEE Access, 2019 Bitcoin is a decentralized digital currency that has gained significant attention and growth in recent years. Unlike traditional currencies, Bitcoin does not rely on a centralized authority to control the supply, distribution, and verification of the ...
Sehyun Park +3 more
doaj +1 more source
Revista Minerva, 2020 El presente artículo tiene como objetivo analizar la factibilidad de la implementación de criptomonedas como un medio para el financiamiento de la deuda pública externa de El Salvador.
Kimberly Michelle Sandoval-Guzmán +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Peer-to-peer energy trading based on a hybrid blockchain system
Energy Reports, 2023 The emergence of distributed energy and prosumers has greatly promoted the reform of the energy market. Blockchain technology provides a very potent solution for distributed energy transactions, however, blockchain technology still develops slowly in the
Chenggang Mu +5 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Maintaining unlinkability in group based P2P environments [PDF]
, 2009 In the wake of the success of Peer-to-Peer (P2P) networking, security has arisen as one of its main concerns, becoming a key issue when evaluating a P2P system.
Joan Arnedo-Moreno +3 more
core +1 more source
The Micro, Small and Medium Enterprises Financing Based on Financial Technology
Jurnal Ilmiah Akuntansi, 2023 Financial technology innovations that are currently developing have provided convenience for the user community in the fields of financial systems, asset management to micro and small business (MSME) financing.
Ica Rika Candraningrat +4 more
doaj +1 more source
Chedar: peer-to-peer middleware [PDF]
Proceedings 20th IEEE International Parallel & Distributed Processing Symposium, 2006 In this paper we present a new peer-to-peer (P2P) middleware called CHEap Distributed ARchitecture (Chedar). Chedar is totally decentralized and can be used as a basis for P2P applications. Chedar tries to continuously optimize its overlay network topology for maximum performance.
Auvinen, Annemari +4 more
openaire +2 more sources